2025
A Honduran Prevalence Study on Soil-Transmitted Helminths Highlights Serological Antibodies to Tm-WAP49 as a Diagnostic Marker for Exposure to Human Trichuriasis.
Briggs N, Versteeg L, Mejia R, Pollet J, Villar M, Zhan B, Segal G, Novak S, Lenihan P, Musgrave P, Ellis V, Coello C, Sastry K, Craft J, Hotez P, Bottazzi M. A Honduran Prevalence Study on Soil-Transmitted Helminths Highlights Serological Antibodies to Tm-WAP49 as a Diagnostic Marker for Exposure to Human Trichuriasis. American Journal Of Tropical Medicine And Hygiene 2025 PMID: 39933187, DOI: 10.4269/ajtmh.24-0514.Peer-Reviewed Original ResearchSoil-transmitted helminthsReceiver-operating characteristic analysisSerological assaysFecal examinationDiagnostic toolIndirect ELISAGold standard testRoundworm infectionDiseases of humansRecombinant proteinsValidation cohortScreening cohortActive infectionInfections rankControl seraHuman trichuriasisDiagnostic markerRelationship to chronic diseasesClinical questionsWestern blottingDiagnostic potentialInfectionWhipwormCharacteristic analysisPrevalence studies
2024
The amalgam of naive CD4+ TÂ cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
Even Z, Meli A, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky D, Kong Y, Wang Y, Waizman D, Rice T, De Kumar B, Wang X, Palm N, Craft J, Basu M, Ghosh S, Rothlin C. The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response. Immunity 2024, 57: 1893-1907.e6. PMID: 39096910, PMCID: PMC11421571, DOI: 10.1016/j.immuni.2024.07.006.Peer-Reviewed Original ResearchT cell receptorImmune responseNaive CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cellsIFN-IHelminth infectionsNippostrongylus brasiliensis infectionDecreased immune responseType I interferonNaive TT cellsMemory-likeUnrelated antigensTranscriptional changesExtracellular matrixSPF miceCell receptorsI interferonGerm-freeResponse to certain environmental cuesInfectionMiceFunctional changesCell transcriptional statesTranscriptional heterogeneity
2022
Mucocutaneous Leishmaniasis in a Pregnant Immigrant
Briggs N, Wei BM, Ahuja C, Baker C, Palacios C, Lee E, O’Grady N, Singanamala S, Singh K, Bandaranayake TD, Cohen JM, Damsky W, Davis MW, Mejia R, Nelson CA, Topal JE, Azar MM. Mucocutaneous Leishmaniasis in a Pregnant Immigrant. Open Forum Infectious Diseases 2022, 9: ofac360. PMID: 35928503, PMCID: PMC9345408, DOI: 10.1093/ofid/ofac360.Peer-Reviewed Original Research
2016
The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections
Briggs N, Weatherhead J, Sastry KJ, Hotez PJ. The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections. PLOS Neglected Tropical Diseases 2016, 10: e0004944. PMID: 27632204, PMCID: PMC5025185, DOI: 10.1371/journal.pntd.0004944.Peer-Reviewed Original Research
2014
Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections
Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections. Expert Review Of Vaccines 2014, 13: 321-331. PMID: 24392641, PMCID: PMC3934375, DOI: 10.1586/14760584.2014.872035.Peer-Reviewed Original ResearchConceptsSoil-transmitted nematode infectionsPhase 1 clinical testingAntigen selectionHelminth-endemic regionsSabin Vaccine Institute Product Development PartnershipAntigen-specific IgEHuman hookworm vaccineProtective immunityHookworm infectionHookworm vaccinePreclinical evaluationClinical developmentClinical testingAntigen discoveryNematode infectionVaccineInfectionAntigenProduct development partnershipsAscaris eggsIgEAscariasisTrichuriasisAscarisImmunity
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