2025
Gestational trophoblastic disease: STR genotyping for precision diagnosis
Rozenova K, Buza N, Hui P. Gestational trophoblastic disease: STR genotyping for precision diagnosis. Expert Review Of Molecular Diagnostics 2025, 25: 1-19. PMID: 39801212, DOI: 10.1080/14737159.2025.2453506.Peer-Reviewed Original ResearchConceptsShort tandem repeatsGestational trophoblastic diseaseShort tandem repeat genotypingDiagnosis of gestational trophoblastic diseaseGestational trophoblastic tumorsHydatidiform moleSTR genotypingTrophoblastic tumorDifferential diagnosis of gestational trophoblastic diseaseRepetitive DNA sequencesManagement of gestational trophoblastic diseaseSubclassification of hydatidiform molesGestational trophoblastic neoplasmsPrognostication of patientsPaternity testingNon-neoplastic natureHuman genomeTandem repeatsDNA sequencesForensic identityTrophoblastic diseaseTrophoblastic neoplasmsGynecologic conditionsDiagnostic workupClinical outcomes
2024
Mixed Gestational Trophoblastic Tumors—Challenging Clinicopathological Presentations
Niu N, Buza N, Hui P. Mixed Gestational Trophoblastic Tumors—Challenging Clinicopathological Presentations. International Journal Of Gynecological Pathology 2024, 44: 42-48. PMID: 38959396, DOI: 10.1097/pgp.0000000000001044.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorSerum human chorionic gonadotropinHuman chorionic gonadotropinTrophoblastic tumorImmune checkpoint inhibitor therapyActinomycin D therapyMethotrexate-based chemotherapyVariable clinicopathological presentationsCheckpoint inhibitor therapyGestational trophoblastic tumorsSerum hCG levelsExtrauterine metastasesMultiagent chemotherapyVaginal bleedingHCG levelsHydatidiform moleInhibitor therapyCervical massUterine massGestational originEndometrial biopsyClinicopathological presentationPatient ageDisease-freeDiandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction?
Nagy A, Niu N, Sun T, Buza N, Hui P. Diandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction? Histopathology 2024, 85: 879-888. PMID: 39031756, DOI: 10.1111/his.15247.Peer-Reviewed Original ResearchPositive predictive valueTriploid gestationsPartial moleTrophoblastic hyperplasiaVillous sizeCistern formationHistological parametersPostmolar gestational trophoblastic neoplasiaTriploid partial molesGenotype-phenotype correlation studiesGestational trophoblastic neoplasiaPartial hydatidiform moleModerate interobserver agreementVillous populationsTrophoblastic neoplasiaGestational weeksHydatidiform moleClinical presentationPatient ageDigynic triploidyAbnormal histologyInterobserver agreementGestationSyncytiotrophoblastHistological assessment
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