2013
Differentiating Patterns of Amygdala-Frontal Functional Connectivity in Schizophrenia and Bipolar Disorder
Liu H, Tang Y, Womer F, Fan G, Lu T, Driesen N, Ren L, Wang Y, He Y, Blumberg HP, Xu K, Wang F. Differentiating Patterns of Amygdala-Frontal Functional Connectivity in Schizophrenia and Bipolar Disorder. Schizophrenia Bulletin 2013, 40: 469-477. PMID: 23599250, PMCID: PMC3932086, DOI: 10.1093/schbul/sbt044.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityBipolar disorderBD groupPrefrontal cortexHealthy controlsFunctional connectivityResting-state functional magnetic resonance imagingNeural system abnormalitiesDorsal lateral prefrontal cortexFunctional magnetic resonance imagingMagnetic resonance imagingVentral prefrontal cortexClinical characteristicsSystem abnormalitiesSuperficial amygdalaAnatomic mapAmygdala subregionsHC groupResonance imagingLateral prefrontal cortexAmygdalaSZ groupSchizophreniaDisordersSignificant differences
2008
Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence
Driesen NR, Leung HC, Calhoun VD, Constable RT, Gueorguieva R, Hoffman R, Skudlarski P, Goldman-Rakic PS, Krystal JH. Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence. Biological Psychiatry 2008, 64: 1026-1034. PMID: 18823880, PMCID: PMC2650279, DOI: 10.1016/j.biopsych.2008.07.029.Peer-Reviewed Original ResearchConceptsMemory taskPrefrontal activityMemory maintenanceBrain activationFunctional Magnetic Resonance Imaging EvidenceWorking Memory MaintenanceCognitive impairmentHealthy comparison participantsPrefrontal cortical activityFunctional magnetic resonanceMemory loadComparison participantsTask accuracyDistinct neurobiologyCortical activityHealthy participantsBasic research insightsImaging EvidenceMemoryCortical deficitsCortical functionPoor performanceTaskSchizophreniaResponse phase
1999
Symptom Assessment in Schizophrenic Prodromal States
Miller T, McGlashan T, Woods S, Stein K, Driesen N, Corcoran C, Hoffman R, Davidson L. Symptom Assessment in Schizophrenic Prodromal States. Psychiatric Quarterly 1999, 70: 273-287. PMID: 10587984, DOI: 10.1023/a:1022034115078.Peer-Reviewed Original ResearchConceptsProdromal symptomsEarly interventionLife-long illnessLong-term courseOnset of schizophreniaPublic health implicationsBetter prognosisSymptom assessmentAvailable treatmentsProdromal patientsPsychotic illnessProdromal stateProdromal stageSymptom severityNeurobiological deficitsIllnessHealth implicationsPatientsLong illnessSymptomsStructured interviewsSchizophreniaClinical workInterventionAssessment instruments