2024
Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance
Wang N, Zhu B, Allnutt M, Grijalva R, Zhao H, Chandra S. Decoding transcriptomic signatures of cysteine string protein alpha–mediated synapse maintenance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320064121. PMID: 38833477, PMCID: PMC11181078, DOI: 10.1073/pnas.2320064121.Peer-Reviewed Original ResearchConceptsSynapse maintenanceTranscriptional changesSynaptogenic adhesion moleculesGene ontology analysisKO miceKO brainMaintenance in vivoCell-cell interactionsGlial cellsSingle-nucleus transcriptomesOntology analysisCspADifferential expressionNeuron-glia interactionsAutophagy-related genesProtein AGenesCell typesNeurodegenerative diseasesInhibitory synapsesLittermate controlsSynaptic pathwaysAdhesion moleculesGlial responseSynapse
2023
cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning
Wang X, Zhou L, Dong B, Xu F, Wang D, Shen E, Cai X, Wang Y, Wang N, Ji S, Chen W, Schonewille M, Zhu J, De Zeeuw C, Shen Y. cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning. ELife 2023, 12: e80875. PMID: 37159499, PMCID: PMC10171863, DOI: 10.7554/elife.80875.Peer-Reviewed Original ResearchEndothelin-1–Endothelin receptor B complex contributes to oligodendrocyte differentiation and myelin deficits during preterm white matter injury
Du M, Wang N, Xin X, Yan C, Gu Y, Wang L, Shen Y. Endothelin-1–Endothelin receptor B complex contributes to oligodendrocyte differentiation and myelin deficits during preterm white matter injury. Frontiers In Cell And Developmental Biology 2023, 11: 1163400. PMID: 37009471, PMCID: PMC10063893, DOI: 10.3389/fcell.2023.1163400.Peer-Reviewed Original Research
2022
Potassium channel K(ir) 4.1 regulates oligodendrocyte differentiation via intracellular pH regulation.
Wang N, Zhou L, Shao CY, Wang XT, Zhang N, Ma J, Hu HL, Wang Y, Qiu M, Shen Y. Potassium channel K(ir) 4.1 regulates oligodendrocyte differentiation via intracellular pH regulation. Glia 2022, 70: 2093-2107. PMID: 35775976, DOI: 10.1002/glia.24240.Peer-Reviewed Original ResearchPotassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
. Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation. Glia 2022, 70: 2093-2107. PMID: 35775976, DOI: 10.1002/glia.24240.Peer-Reviewed Original ResearchKIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization
Zheng R, Du Y, Wang X, Liao T, Zhang Z, Wang N, Li X, Shen Y, Shi L, Luo J, Xia J, Wang Z, Xu J. KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization. ELife 2022, 11: e72483. PMID: 35138249, PMCID: PMC8828051, DOI: 10.7554/elife.72483.Peer-Reviewed Original Research
2021
Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective
Su L, Wang N, Han J, Shen Y. Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective. The Neuroscientist 2021, 28: 453-468. PMID: 34088252, PMCID: PMC9449437, DOI: 10.1177/10738584211021018.Peer-Reviewed Original ResearchDifferent roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5
Wang N, Wang D, Hou X, Li X, Shen Y. Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5. Molecular Biology Reports 2021, 48: 595-600. PMID: 33394235, DOI: 10.1007/s11033-020-06103-0.Peer-Reviewed Original Research
2020
Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells.
Xu FX, Zhou L, Wang XT, Jia F, Ma KY, Wang N, Lin L, Xu FQ, Shen Y. Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells. Nature Neuroscience 2020, 23: 1041-1043. PMID: 31570863, DOI: 10.1038/s41593-019-0475-3.Peer-Reviewed Original ResearchGab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.
Zhou L, Shao CY, Xie YJ, Wang N, Xu SM, Luo BY, Wu ZY, Ke YH, Qiu M, Shen Y. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. ELife 2020, 9 PMID: 31944179, PMCID: PMC6984811, DOI: 10.7554/eLife.52056.Peer-Reviewed Original ResearchGab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
Zhou L, Shao C, Xie Y, Wang N, Xu S, Luo B, Wu Z, Ke Y, Qiu M, Shen Y. Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination. ELife 2020, 9: e52056. PMID: 31944179, PMCID: PMC6984811, DOI: 10.7554/elife.52056.Peer-Reviewed Original Research
2019
Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells
Xu F, Zhou L, Wang X, Jia F, Ma K, Wang N, Lin L, Xu F, Shen Y. Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells. Nature Neuroscience 2019, 23: 1041-1043. PMID: 31570863, DOI: 10.1038/s41593-019-0475-3.Peer-Reviewed Original ResearchNumb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors.
Wang N, Wang DD, Shen Y. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters 2019, 707: 134291. PMID: 31129078, DOI: 10.1016/j.neulet.2019.134291.Peer-Reviewed Original ResearchNumb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors
Wang N, Wang D, Shen Y. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Neuroscience Letters 2019, 707: 134291. PMID: 31129078, DOI: 10.1016/j.neulet.2019.134291.Peer-Reviewed Original Research
2018
Numb-p72, but not Numb-p65, contributes to the trafficking of group I metabotropic glutamate receptors.
Wang N, Cai XY, Gao W, Shen Y. Numb-p72, but not Numb-p65, contributes to the trafficking of group I metabotropic glutamate receptors. Neuroreport 2018, 29: 902-906. PMID: 29762249, DOI: 10.1097/WNR.0000000000001051.Peer-Reviewed Original ResearchNumb-p72, but not Numb-p65, contributes to the trafficking of group I metabotropic glutamate receptors
Wang N, Cai X, Gao W, Shen Y. Numb-p72, but not Numb-p65, contributes to the trafficking of group I metabotropic glutamate receptors. Neuroreport 2018, 29: 902-906. PMID: 29762249, DOI: 10.1097/wnr.0000000000001051.Peer-Reviewed Original ResearchCelecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.
Zhou L, Zhou L, Su LD, Cao SL, Xie YJ, Wang N, Shao CY, Wang YN, Zhou JH, Cowell JK, Shen Y. Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience 2018, 38: 3346-3357. PMID: 29491011, PMCID: PMC5884462, DOI: 10.1523/JNEUROSCI.3245-17.2018.Peer-Reviewed Original ResearchCelecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy
Zhou L, Zhou L, Su L, Cao S, Xie Y, Wang N, Shao C, Wang Y, Zhou J, Cowell J, Shen Y. Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy. Journal Of Neuroscience 2018, 38: 3346-3357. PMID: 29491011, PMCID: PMC5884462, DOI: 10.1523/jneurosci.3245-17.2018.Peer-Reviewed Original ResearchPotassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2&agr; ablation
Wang N, Hu Y, Su L. Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2&agr; ablation. Neuroreport 2018, 29: 59-64. PMID: 29112675, DOI: 10.1097/wnr.0000000000000933.Peer-Reviewed Original Research
2016
Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons.
Xu J, Wang N, Luo JH, Xia J. Syntabulin regulates the trafficking of PICK1-containing vesicles in neurons. Scientific Reports 2016, 6: 20924. PMID: 26868290, PMCID: PMC4751430, DOI: 10.1038/srep20924.Peer-Reviewed Original Research