2025
Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery
Fallon J, Hashemaghaie M, Peterson C, Tran D, Wu S, Valdes J, Pedicini N, Adams M, Soltis M, Mansour W, Wright M, Raghunathan K, Treggiari M, Sasannejad C, Devinney M. Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery. BMJ Open 2025, 15: e091099. PMID: 40081971, PMCID: PMC11907038, DOI: 10.1136/bmjopen-2024-091099.Peer-Reviewed Original ResearchConceptsNon-cardiac surgeryTotal sleep timeEfficacy of suvorexantRandomised controlled trialsTwo-sample t-testPostoperative sleepOlder patientsAssociated with prolonged hospitalizationDelirium severityDecrease delirium severityIncreased total sleep timeStudy drug dosePlacebo-controlled trialPostoperative inpatient stayLong-term cognitive impairmentFood and Drug AdministrationOlder surgical patientsPostoperative sleep disturbancePrimary endpoint dataRisk of deliriumT-testOral suvorexantInstitutional review boardPostoperative delirium severityOrexin-1
2016
Pre-diagnostic Sleep Duration and Sleep Quality in Relation to Subsequent Cancer Survival.
Phipps AI, Bhatti P, Neuhouser ML, Chen C, Crane TE, Kroenke CH, Ochs-Balcom H, Rissling M, Snively BM, Stefanick ML, Treggiari MM, Watson NF. Pre-diagnostic Sleep Duration and Sleep Quality in Relation to Subsequent Cancer Survival. Journal Of Clinical Sleep Medicine 2016, 12: 495-503. PMID: 26612513, PMCID: PMC4795275, DOI: 10.5664/jcsm.5674.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeShort sleep durationSleep characteristicsHazard ratioCancer survivalCancer sitesSleep durationHealth initiativesPrimary invasive cancerCancer-specific survivalConfidence intervalsPoor sleep qualityFrequent snoringStudy armsCox regressionCancer outcomesInvasive cancerCommon cancerWHI participantsPhysical activitySleep qualityElevated riskCancer typesCancerMarital status
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