2025
Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery
Fallon J, Hashemaghaie M, Peterson C, Tran D, Wu S, Valdes J, Pedicini N, Adams M, Soltis M, Mansour W, Wright M, Raghunathan K, Treggiari M, Sasannejad C, Devinney M. Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery. BMJ Open 2025, 15: e091099. PMID: 40081971, PMCID: PMC11907038, DOI: 10.1136/bmjopen-2024-091099.Peer-Reviewed Original ResearchConceptsNon-cardiac surgeryTotal sleep timeEfficacy of suvorexantRandomised controlled trialsTwo-sample t-testPostoperative sleepOlder patientsAssociated with prolonged hospitalizationDelirium severityDecrease delirium severityIncreased total sleep timeStudy drug dosePlacebo-controlled trialPostoperative inpatient stayLong-term cognitive impairmentFood and Drug AdministrationOlder surgical patientsPostoperative sleep disturbancePrimary endpoint dataRisk of deliriumT-testOral suvorexantInstitutional review boardPostoperative delirium severityOrexin-1
2015
Dexmedetomidine Does Not Affect Evoked Potentials During Spine Surgery
Rozet I, Metzner J, Brown M, Treggiari MM, Slimp JC, Kinney G, Sharma D, Lee LA, Vavilala MS. Dexmedetomidine Does Not Affect Evoked Potentials During Spine Surgery. Anesthesia & Analgesia 2015, 121: 492-501. PMID: 26097987, DOI: 10.1213/ane.0000000000000840.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, IntravenousAnesthetics, IntravenousDexmedetomidineDouble-Blind MethodEvoked PotentialsEvoked Potentials, MotorEvoked Potentials, SomatosensoryEvoked Potentials, VisualFemaleHumansHypnotics and SedativesIntraoperative Neurophysiological MonitoringMaleMiddle AgedOrthopedic ProceduresPiperidinesPropofolReaction TimeRemifentanilSpineTime FactorsConceptsEffect of dexmedetomidineVisual EPsSpine surgeryEnd pointElective spine surgeryPlacebo-controlled trialPrimary end pointSecondary end pointsLatency N1Motor EPsPlacebo groupStudy drugAdult patientsNormal salineLatency P1DexmedetomidineSomatosensory EPsIRB approvalRelevant dosesEP recordingInformed consentPatientsSurgeryEvoked PotentialsAnesthesia
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