2024
Neurofeedback: potential for abuse and regulatory frameworks in the United States
Furnari F, Park H, Yaffe G, Hampson M. Neurofeedback: potential for abuse and regulatory frameworks in the United States. Philosophical Transactions Of The Royal Society B Biological Sciences 2024, 379: 20230099. PMID: 39428883, PMCID: PMC11513161, DOI: 10.1098/rstb.2023.0099.Peer-Reviewed Original Research
2023
Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial
Rance M, Zhao Z, Zaboski B, Kichuk S, Romaker E, Koller W, Walsh C, Harris-Starling C, Wasylink S, Adams T, Gruner P, Pittenger C, Hampson M. Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial. Psychiatry Research 2023, 328: 115458. PMID: 37722238, PMCID: PMC10695074, DOI: 10.1016/j.psychres.2023.115458.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAnterior prefrontal cortexControl groupDouble-blind clinical trialDouble-blind trialPrimary outcome measureCompulsive disorderHarm/checkingMechanism of actionYale-Brown ObsessiveSecondary outcomesSessions of neurofeedbackActive groupClinical trialsOutcome measuresPrimary symptomsSymptom ScaleObsessive-compulsive symptomsPrefrontal cortexSymptomsTraining protocolGreater reductionSignificant differencesPatientsSham feedbackProtocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome
Awasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez T, Sukhodolsky D, Hampson M. Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Psychiatry Research Neuroimaging 2023, 336: 111692. PMID: 37673711, PMCID: PMC10722977, DOI: 10.1016/j.pscychresns.2023.111692.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingStudy protocolChronic tic disorderSupplementary motor areaLower functional connectivityMagnetic resonance imagingResearch study protocolLarge trialsClinical trialsTic disordersMotor areaBrain areasControl groupResonance imagingBrain regionsNew trialsFunctional connectivityNeurofeedback interventionFMRI neurofeedbackNF protocolTrialsNF studiesSyndromeInterventionAmygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial
Zhao Z, Duek O, Seidemann R, Gordon C, Walsh C, Romaker E, Koller W, Horvath M, Awasthi J, Wang Y, O’Brien E, Fichtenholtz H, Hampson M, Harpaz-Rotem I. Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial. Translational Psychiatry 2023, 13: 177. PMID: 37230984, PMCID: PMC10209552, DOI: 10.1038/s41398-023-02467-6.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderControl groupAmygdala activityPTSD treatmentDouble-blind clinical trialStress disorderDouble-blind trialSecondary outcome measurementsTrauma recallNeurofeedback trainingGreater improvementAmygdala controlsPotential clinical applicationsSymptom scoresActive groupClinical trialsTreatment successOutcome measurementsTrauma scriptsSymptom reductionNeurofeedback interventionPTSD symptomsFMRI neurofeedbackAmygdalaNeural markers
2022
HALO: A software tool for real‐time head alignment in the MR scanner
Zhao Z, Galiana G, Zillo C, Camarro T, Qiu M, Papademetris X, Hampson M. HALO: A software tool for real‐time head alignment in the MR scanner. Magnetic Resonance In Medicine 2022, 89: 1506-1513. PMID: 36426774, PMCID: PMC10753491, DOI: 10.1002/mrm.29535.Peer-Reviewed Original ResearchSystemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionObsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Grazioplene RG, DeYoung CG, Hampson M, Anticevic A, Pittenger C. Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth. Translational Psychiatry 2022, 12: 328. PMID: 35948535, PMCID: PMC9365814, DOI: 10.1038/s41398-022-02013-w.Peer-Reviewed Original ResearchConceptsWhite matter abnormalitiesObsessive-compulsive disorderObsessive-compulsive symptomsGeneral psychopathologyCorpus callosumWhite matterFractional anisotropyDistinct white matter abnormalitiesAnterior corpus callosumPosterior corpus callosumWhite matter correlatesAge-dependent mannerWhite matter measuresGeneral psychopathology factorWhite matter microstructureNeurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial
Tinaz S, Kamel S, Aravala SS, Elfil M, Bayoumi A, Patel A, Scheinost D, Sinha R, Hampson M. Neurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial. NeuroImage Clinical 2022, 34: 102980. PMID: 35247729, PMCID: PMC8897714, DOI: 10.1016/j.nicl.2022.102980.Peer-Reviewed Original ResearchConceptsKinesthetic motor imageryMotor function scoresMild Parkinson's diseaseParkinson's diseaseFunctional connectivityFunction scoresMI trainingSecondary clinical outcomesClinical outcome measuresRandomized clinical trialsWhole-brain functional connectivityPost-training changeFunctional connectivity strengthMotor imageryMotor imagery trainingDorsomedial frontal cortexDistinct neural circuitsClinical outcomesImaging outcomesSubjective improvementClinical trialsMotor functionMotor examFrontal cortexOutcome measures
2021
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking children
2020
Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist)
Ros T, Enriquez-Geppert S, Zotev V, Young KD, Wood G, Whitfield-Gabrieli S, Wan F, Vuilleumier P, Vialatte F, Van De Ville D, Todder D, Surmeli T, Sulzer JS, Strehl U, Sterman MB, Steiner NJ, Sorger B, Soekadar SR, Sitaram R, Sherlin LH, Schönenberg M, Scharnowski F, Schabus M, Rubia K, Rosa A, Reiner M, Pineda JA, Paret C, Ossadtchi A, Nicholson AA, Nan W, Minguez J, Micoulaud-Franchi JA, Mehler DMA, Lührs M, Lubar J, Lotte F, Linden DEJ, Lewis-Peacock JA, Lebedev MA, Lanius RA, Kübler A, Kranczioch C, Koush Y, Konicar L, Kohl SH, Kober SE, Klados MA, Jeunet C, Janssen TWP, Huster RJ, Hoedlmoser K, Hirshberg LM, Heunis S, Hendler T, Hampson M, Guggisberg AG, Guggenberger R, Gruzelier JH, Göbel RW, Gninenko N, Gharabaghi A, Frewen P, Fovet T, Fernández T, Escolano C, Ehlis AC, Drechsler R, deCharms R, Debener S, De Ridder D, Davelaar EJ, Congedo M, Cavazza M, Breteler MHM, Brandeis D, Bodurka J, Birbaumer N, Bazanova OM, Barth B, Bamidis PD, Auer T, Arns M, Thibault RT. Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). Brain 2020, 143: 1674-1685. PMID: 32176800, PMCID: PMC7296848, DOI: 10.1093/brain/awaa009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConnectome-based neurofeedback: A pilot study to improve sustained attention
Scheinost D, Hsu TW, Avery EW, Hampson M, Constable RT, Chun MM, Rosenberg MD. Connectome-based neurofeedback: A pilot study to improve sustained attention. NeuroImage 2020, 212: 116684. PMID: 32114151, PMCID: PMC7165055, DOI: 10.1016/j.neuroimage.2020.116684.Peer-Reviewed Original ResearchConceptsFunctional connectivityRt-fMRIReal-time functional magnetic resonance imaging (rt-fMRI) neurofeedbackWhole-brain functional connectivityClinical trial designFunctional magnetic resonance imaging (fMRI) neurofeedbackDistinct brain areasConnectome-based modelsClinical symptomsTrial designBrain areasBrain regionsSustained attentionTherapeutic toolPilot studyBrain activityFunctional connectionsSymptomsNeurofeedbackFunctional networksTraining durationAttention taskComplex functional networksPilot sample
2019
Neurofeedback
Hampson M, Ruiz S, Ushiba J. Neurofeedback. NeuroImage 2019, 218: 116473. PMID: 31863913, DOI: 10.1016/j.neuroimage.2019.116473.Commentaries, Editorials and LettersRandomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback interventionEffect of deactivation of activity patterns related to smoking cue reactivity on nicotine addiction
Bu J, Young KD, Hong W, Ma R, Song H, Wang Y, Zhang W, Hampson M, Hendler T, Zhang X. Effect of deactivation of activity patterns related to smoking cue reactivity on nicotine addiction. Brain 2019, 142: 1827-1841. PMID: 31135053, DOI: 10.1093/brain/awz114.Peer-Reviewed Original ResearchConceptsSmoking cue reactivityReal-feedback groupBrain activity patternsCue reactivityEEG activity patternsCigarette cravingNicotine addictionSmoking behaviorNumber of cigarettesGold Standard ProgrammeRates of cigaretteNovel therapeutic approachesNicotine-dependent participantsNeurofeedback protocolActivity patternsSmoking amountCigarette smokingSmoking cessationClinical trialsSmoking cuesLong-term effectsNeurofeedback training sessionsTherapeutic approachesTherapeutic efficacyMonths
2018
Control freaks: Towards optimal selection of control conditions for fMRI neurofeedback studies
Sorger B, Scharnowski F, Linden DEJ, Hampson M, Young KD. Control freaks: Towards optimal selection of control conditions for fMRI neurofeedback studies. NeuroImage 2018, 186: 256-265. PMID: 30423429, PMCID: PMC6338498, DOI: 10.1016/j.neuroimage.2018.11.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTime course of clinical change following neurofeedback
Rance M, Walsh C, Sukhodolsky DG, Pittman B, Qiu M, Kichuk SA, Wasylink S, Koller WN, Bloch M, Gruner P, Scheinost D, Pittenger C, Hampson M. Time course of clinical change following neurofeedback. NeuroImage 2018, 181: 807-813. PMID: 29729393, PMCID: PMC6454268, DOI: 10.1016/j.neuroimage.2018.05.001.Peer-Reviewed Original ResearchConceptsClinical changesSymptom changeTime courseBrain functionNeurofeedback studiesPotential clinical toolCrossover designControl interventionsReal neurofeedbackClinical toolTime pointsClinical populationsNeurofeedback effectsInterventionNeurofeedback sessionsNeurofeedbackCurrent brain stateWeeksBrain statesNew studiesCourseSessionsSymptomsDeveloping image sets for inducing obsessive-compulsive checking symptoms
Brooks H, Kichuk SA, Adams TG, Koller WN, Eken HN, Rance M, Monahan S, Wasylink S, Kelmendi B, Pittenger C, Gruner P, Hampson M. Developing image sets for inducing obsessive-compulsive checking symptoms. Psychiatry Research 2018, 265: 249-255. PMID: 29763844, PMCID: PMC6063514, DOI: 10.1016/j.psychres.2018.04.035.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderProvocative imagesSymptom provocationDiagnosis of OCDClinical obsessive-compulsive disorderInduction of anxietyContextual cuesIntrusive thoughtsVisual stimuliOC symptomsCompulsive disorderDiagnostic statusAnxietyStimuliHarmful scenariosSimilar objectsGreat provocationsIndividualsSuggestive imagesProvocationQualitative patternCuesSymptomsResearch studiesFuture studiesData-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network
Scheinost D, Tokoglu F, Hampson M, Hoffman R, Constable RT. Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network. Schizophrenia Bulletin 2018, 45: 415-424. PMID: 29660081, PMCID: PMC6403094, DOI: 10.1093/schbul/sby039.Peer-Reviewed Original ResearchConceptsAuditory Hallucination Rating ScaleIntrinsic connectivity distributionAuditory verbal hallucinationsHealthy controlsFunctional connectivityLateralized connectivitySevere global health problemSeed connectivity analysesBest treatment strategyGlobal health problemWhole-brain connectivityMedial prefrontal cortexPosterior cingulate cortexDefault mode networkSuch patientsPatient groupLeft putamenTreatment strategiesPatientsActionable targetsSchizoaffective disorderCingulate cortexHealth problemsVoxel-based measurePrefrontal cortex
2017
Impaired Value Learning for Faces in Preschoolers With Autism Spectrum Disorder
Wang Q, DiNicola L, Heymann P, Hampson M, Chawarska K. Impaired Value Learning for Faces in Preschoolers With Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 57: 33-40. PMID: 29301667, PMCID: PMC5757250, DOI: 10.1016/j.jaac.2017.10.014.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNonsocial domainsNonsocial tasksSelective attentionSpectrum disorderValue learningSocial attention deficitsDomain-specific impairmentObject valuesTD childrenNonsocial conditionTD controlsTD groupAttention deficitsNonhuman primate studiesSelection of objectsSocial domainsSocial objectsTaskNovel treatment targetsPreschoolersGroup comparisonsPrimate studiesTreatment targetsChildrenIdentifying Potential Mechanisms of Action Underlying Neurofeedback Treatment Response in Depression
Hampson M. Identifying Potential Mechanisms of Action Underlying Neurofeedback Treatment Response in Depression. Biological Psychiatry 2017, 82: 547-548. PMID: 28935097, DOI: 10.1016/j.biopsych.2017.07.001.Commentaries, Editorials and Letters
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