2020
Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes
Lehman H, Kidacki M, Stairs D. Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes. Scientific Reports 2020, 10: 18829. PMID: 33139779, PMCID: PMC7608670, DOI: 10.1038/s41598-020-75866-0.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaCancer typesYear of diagnosisSquamous cell carcinomaEsophageal keratinocytesOverexpression of EGFRHuman esophageal keratinocytesAggressive cell typesFatal cancer typePoor prognosisCell carcinomaTwist2 expressionEGFR overexpressionEGFREMT-inducing geneNFkBResponsive targetsTwist2Paucity of researchCell typesPresent studyKeratinocytesP120-cateninOverexpressionComplete loss
2018
NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation
Lehman HL, Kidacki M, Warrick JI, Stairs DB. NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation. Oncotarget 2018, 9: 11180-11196. PMID: 29541406, PMCID: PMC5834278, DOI: 10.18632/oncotarget.24358.Peer-Reviewed Original ResearchP120-cateninMolecular pathways downstreamInvasive processEGFR overexpressionHuman ESCC cellsCentral regulatorPathways downstreamEsophageal squamous cell carcinomaUpstream regulatorTumor suppressorAggressive cell typesCell typesP120ctnInvasive potentialHuman esophageal keratinocytesEsophageal keratinocytesOverexpressionESCC cellsOrganotypic culture modelRho-kinaseNFkBComplete lossRegulationRegulatorCulture model
2017
The Interplay Between p120ctn and EGFR Causes Esophageal Squamous Cell Carcinoma Invasion Through NFkB
Lehman H, Welsh P, Kidacki M, Warrick J, Stairs D. The Interplay Between p120ctn and EGFR Causes Esophageal Squamous Cell Carcinoma Invasion Through NFkB. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.178.11.Peer-Reviewed Original ResearchCell typesInvasion pathwaysGene Ontology functional categoriesInvasive phenotypeTypes of genesGlobal gene analysisUPAR expressionActive RhoA levelsEGFR overexpressionGene expression dataInhibition of RhoEsophageal squamous cell carcinoma invasionFunctional categoriesP120-cateninRhoA GTPaseCentral regulatorEsophageal squamous cell carcinomaActivity downstreamUpstream regulatorTumor suppressorP120ctnGene combinationsCancer genesExpression dataRhoA levels