2020
Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes
Lehman H, Kidacki M, Stairs D. Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes. Scientific Reports 2020, 10: 18829. PMID: 33139779, PMCID: PMC7608670, DOI: 10.1038/s41598-020-75866-0.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaCancer typesYear of diagnosisSquamous cell carcinomaEsophageal keratinocytesOverexpression of EGFRHuman esophageal keratinocytesAggressive cell typesFatal cancer typePoor prognosisCell carcinomaTwist2 expressionEGFR overexpressionEGFREMT-inducing geneNFkBResponsive targetsTwist2Paucity of researchCell typesPresent studyKeratinocytesP120-cateninOverexpressionComplete loss
2018
NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation
Lehman HL, Kidacki M, Warrick JI, Stairs DB. NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation. Oncotarget 2018, 9: 11180-11196. PMID: 29541406, PMCID: PMC5834278, DOI: 10.18632/oncotarget.24358.Peer-Reviewed Original ResearchP120-cateninMolecular pathways downstreamInvasive processEGFR overexpressionHuman ESCC cellsCentral regulatorPathways downstreamEsophageal squamous cell carcinomaUpstream regulatorTumor suppressorAggressive cell typesCell typesP120ctnInvasive potentialHuman esophageal keratinocytesEsophageal keratinocytesOverexpressionESCC cellsOrganotypic culture modelRho-kinaseNFkBComplete lossRegulationRegulatorCulture model