2020
Umbilical Cord-derived Mesenchymal Stem Cells for COVID-19 Patients with Acute Respiratory Distress Syndrome (ARDS).
Lanzoni G, Linetsky E, Correa D, Alvarez R, Marttos A, Hirani K, Cayetano S, Castro J, Paidas M, Efantis Potter J, Xu X, Glassberg M, Tan J, Patel A, Goldstein B, Kenyon N, Baidal D, Alejandro R, Vianna R, Ruiz P, Caplan A, Ricordi C. Umbilical Cord-derived Mesenchymal Stem Cells for COVID-19 Patients with Acute Respiratory Distress Syndrome (ARDS). CellR4-- Repair, Replacement, Regeneration, & Reprogramming 2020, 8 PMID: 34164564, PMCID: PMC8218794, DOI: 10.32113/cellr4_20204_2839.Peer-Reviewed Original ResearchAcute respiratory distress syndromeIntensive care unitCOVID-19 patientsAcute lung injurySerious adverse eventsRespiratory distress syndromeDiabetes Research InstituteJackson Memorial HospitalClinical trialsUC-MSCsAdverse eventsMesenchymal stem cellsUmbilical cordCytokine stormDistress syndromeCare unitALI/acute respiratory distress syndromeICU COVID-19 patientsEarly phase clinical trialsSevere COVID-19Uncontrolled clinical trialsImmune-based diseasesRegulatory cell populationsT cell reactionsInfusion of vehicle
2015
Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult
Barnea E, Almogi-Hazan O, Or R, Mueller M, Ria F, Weiss L, Paidas M. Immune regulatory and neuroprotective properties of preimplantation factor: From newborn to adult. Pharmacology & Therapeutics 2015, 156: 10-25. PMID: 26546485, DOI: 10.1016/j.pharmthera.2015.10.008.Peer-Reviewed Original ResearchConceptsPreImplantation FactorNeurological disordersAdverse maternal environmentSynthetic preimplantation factorEarly adverse eventsHigh safety profileFast track designationComplex neurological disorderEmbryonic-maternal interactionColon ulcerationPIF's effectHost diseaseLeukemia effectAdverse eventsLiver inflammationTransplant acceptanceBrain infectionNeuroprotective effectsAutoimmune disordersImmune suppressionNeuroprotective propertiesImmune modulationNeonatal prematuritySupraphysiological dosesSkin ulceration