2024
Dermatologic Changes in Experimental Model of Long COVID
Hussain H, Paidas M, Rajalakshmi R, Fadel A, Ali M, Chen P, Jayakumar A. Dermatologic Changes in Experimental Model of Long COVID. Microorganisms 2024, 12: 272. PMID: 38399677, PMCID: PMC10892887, DOI: 10.3390/microorganisms12020272.Peer-Reviewed Original ResearchMurine hepatitis virus-1Consistent with human studiesAbsence of hair folliclesPost-SARS-CoV-2 infectionHair folliclesAnti-inflammatory responseLong-term health repercussionsPulmonary complicationsFollicle lossDermal layerLiver dysfunctionKidney impairmentCutaneous findingsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Tissue destructionDermatological changesAcute stageCoronavirus disease-19Pathophysiological changesHuman studiesCollagen depositionSkin alterationsSyndrome coronavirus 2
2023
A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection
Masciarella A, Di Gregorio D, Ramamoorthy R, Hussain H, Jayakumar A, Paidas M. A Mouse Model of MHV‐1 Virus Infection for Study of Acute and Long COVID Infection. Current Protocols 2023, 3: e896. PMID: 37867460, PMCID: PMC10606938, DOI: 10.1002/cpz1.896.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pathological changesMouse modelTransgenic miceLong-term organ dysfunctionSARS-CoV-2 pathophysiologyIrreversible neurological complicationsPotential therapeutic interventionsAvailable human dataBiosafety level 2 laboratoryNon-human primatesBiosafety level 3 laboratoryNeurological complicationsOrgan dysfunctionAcute stageClinical symptomsLong-term effectsSevere casesClinical observationsViral infectionTherapeutic interventionsMHV-1Animal preparationsWeight lossBSL-3 laboratory