2025
Delivering on the Promise of Precision Oncology in Prostate Cancer: Prediagnostic Strategies, Postdiagnostic Applications, and Future Directions. A Narrative Review
Diaz G, Palencia P, Leapman M. Delivering on the Promise of Precision Oncology in Prostate Cancer: Prediagnostic Strategies, Postdiagnostic Applications, and Future Directions. A Narrative Review. Journal Of Urologic Oncology 2025, 23: 4-13. DOI: 10.22465/juo.255000120006.Peer-Reviewed Original ResearchLocalized prostate cancerProstate cancerPrecision oncologyManagement of localized prostate cancerRefine risk predictionActive surveillance protocolsSurveillance protocolsTumor heterogeneityTreatment selectionPatient variablesOptimal outcomesRisk assessment toolBiomarker discoveryOvertreatmentOncologyCancerRisk predictionBiological characteristicsProstateRadical prostatectomy is associated with favorable outcomes in patients over 80 years old.
Kim I, Leapman M, Kim M, Rahman S, Sprenkle P, Renzulli J, Brito J, Hyams E, Kim J, Pareek G, Kim I. Radical prostatectomy is associated with favorable outcomes in patients over 80 years old. American Journal Of Clinical And Experimental Urology 2025, 13: 33-42. PMID: 40124572, PMCID: PMC11928824, DOI: 10.62347/nkgs2301.Peer-Reviewed Original ResearchProstate cancer-specific survivalLocalized prostate cancerRadical prostatectomyProstate cancerPatients treated with radical prostatectomyAssociated with higher OSAssociated with favorable outcomesCancer-specific survivalTreated with radiotherapyMedian OSMedian PSAFavorable survivalMedian agePatient ageFavorable outcomeHigher OSRadiotherapySEER-17Cox regressionCompare survivalProstatectomyPatientsSurvivalCancerDiagnosis
2024
Associations Between Prostate Magnetic Resonance Imaging, Genomic Testing, and Treatment for Localized Prostate Cancer
Sundaresan V, Wang R, Long J, Sprenkle P, Seibert T, Loeb S, Cooperberg M, Catalona W, Ma X, Gross C, Leapman M. Associations Between Prostate Magnetic Resonance Imaging, Genomic Testing, and Treatment for Localized Prostate Cancer. Urology Practice 2024, 11: 965-973. PMID: 39196719, DOI: 10.1097/upj.0000000000000679.Peer-Reviewed Original ResearchLocalized prostate cancerClinically localized prostate cancerHigh-risk diseaseProstate MRIProstate cancerTreatment intensificationIntensified treatmentGenomic testingTreated patientsProstate magnetic resonance imagingEnd Results databaseLong-term patient outcomesProstate cancer prognosisRetrospective cohort studyAssociated with decreased oddsRisk stratification toolPrimary study outcomeAssociated with increased oddsMagnetic resonance imagingResults databaseStratification toolTreatment patientsCohort studyRisk strataCancer prognosisThe effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy
Lokeshwar S, Ali A, Weiss T, Reynolds J, Shuch B, Ferencz T, Kyriakides T, Mehal W, Brito J, Renzulli J, Leapman M. The effect of a fermented soy beverage among patients with localized prostate cancer prior to radical prostatectomy. BMC Urology 2024, 24: 102. PMID: 38702664, PMCID: PMC11067086, DOI: 10.1186/s12894-024-01483-y.Peer-Reviewed Original ResearchConceptsEnd-of-studyProstate cancerRadical prostatectomyTreatment armsDouble-blind randomized trialProstate cancer characteristicsSurgical margin statusLocalized prostate cancerFACT-P scoresBaseline to end-of-studySerum PSACAPRA scoreGleason scorePSA levelsPlacebo-controlledMedium-chain triglyceridesPrimary endpointIntermediate riskClinical stageMargin statusSerum testosteroneRandomization armFACT-PRisk strataITT analysis
2023
PD10-01 ASSOCIATIONS BETWEEN PROSTATE MRI AND GENOMIC TESTING AND TREATMENT INTENSIFICATION AMONG PATIENTS WITH LOCALIZED PROSTATE CANCER
Leapman M, Wang R, Long J, Sprenkle P, Ma X, Gross C. PD10-01 ASSOCIATIONS BETWEEN PROSTATE MRI AND GENOMIC TESTING AND TREATMENT INTENSIFICATION AMONG PATIENTS WITH LOCALIZED PROSTATE CANCER. Journal Of Urology 2023, 209: e326. DOI: 10.1097/ju.0000000000003250.01.Peer-Reviewed Original ResearchLocalized prostate cancerTreatment intensificationProstate cancerProstate MRIGenomic testingPatientsCancerMRIAssociations between patient sociodemographic factors and non-treatment for localized prostate cancer.
Novosel M, Smani S, Marks V, Jeong F, Sprenkle P, Leapman M. Associations between patient sociodemographic factors and non-treatment for localized prostate cancer. Journal Of Clinical Oncology 2023, 41: 307-307. DOI: 10.1200/jco.2023.41.6_suppl.307.Peer-Reviewed Original ResearchHigh-risk prostate cancerLocalized prostate cancerAggressive prostate cancerProstate cancerWhite patientsLower oddsDefinitive treatmentRisk strataSociodemographic factorsMean patient ageNational Cancer DatabaseHigh-risk diseasePatient sociodemographic factorsMultivariable logistic regressionClinical risk criteriaPatient ageImproved survivalBlack patientsInitial treatmentRisk diseaseAsian patientsRetrospective studyBlack raceInsurance statusPatient raceUse of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation
Leapman M, Wang R, Loeb S, Seibert T, Gaylis F, Lowentritt B, Brown G, Chen R, Lin D, Witte J, Cooperberg M, Catalona W, Gross C, Ma X. Use of Monitoring Tests Among Patients With Localized Prostate Cancer Managed With Observation. Journal Of Urology 2023, 209: 710-718. PMID: 36753746, DOI: 10.1097/ju.0000000000003159.Peer-Reviewed Original ResearchConceptsIntermediate-risk prostate cancerMixed-effects Poisson regressionPSA testingProstate biopsyProstate cancerEffects Poisson regressionMedicare beneficiariesPoisson regressionAdditional prostate biopsyRetrospective cohort studyProstate MRILocalized prostate cancerRepeat prostate biopsyRate of biopsyRace/ethnicityCensus tract povertyMedian followCohort studyMedian ageMonitoring testsProvider factorsPSA testClinical riskBiopsySociodemographic factors
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