2024
The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor
Rodriguez Torres C, Wicker N, Puccini de Castro V, Stefinko M, Bennett D, Bernhardt B, Garcia Montes de Oca M, Jallow S, Flitcroft K, Palalay J, Payán Parra O, Stern Y, Koelle M, Voisine C, Woods I, Lo T, Stern M, de la Cova C. The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor. Developmental Biology 2024, 516: 183-195. PMID: 39173814, PMCID: PMC11488645, DOI: 10.1016/j.ydbio.2024.08.014.Peer-Reviewed Original ResearchC-terminal domainEGL-15MPK-1 activationSex myoblastsSem-5CLR-1SOC-1Regulating animal developmentMode of signal transductionPTP-2Cell signaling modulatorsCell-specific differencesRAS pathway activationTissue-specific mechanismsMPK-1IRS proteinsAnimal developmentSOC-3Homeostasis defectsCaenorhabditis elegansGenetic screeningHyp7Kinase RafSignal transductionFGF signaling
2007
C. elegans G Protein Regulator RGS-3 Controls Sensitivity to Sensory Stimuli
Ferkey DM, Hyde R, Haspel G, Dionne HM, Hess HA, Suzuki H, Schafer WR, Koelle MR, Hart AC. C. elegans G Protein Regulator RGS-3 Controls Sensitivity to Sensory Stimuli. Neuron 2007, 53: 39-52. PMID: 17196529, PMCID: PMC1855255, DOI: 10.1016/j.neuron.2006.11.015.Peer-Reviewed Original ResearchConceptsSignal transductionG protein-coupled signal transductionRGS-3G protein signaling (RGS) proteinsHeterotrimeric G proteinsSpecific RGS proteinsRGS proteinsSensory neuronsSignaling proteinsMutant animalsNegative regulatorCalcium-binding proteinsG proteinsCalcium signalingBehavioral defectsTransductionSpecific odorantsProteinDefective responseRegulatorSensory behaviorsSynaptic transmissionIntense sensory stimuliExternal stimuliSignaling