2006
Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant
Lewis JM, Girardi M, Roberts SJ, D Barbee S, Hayday AC, Tigelaar RE. Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant. Nature Immunology 2006, 7: 843-850. PMID: 16829962, DOI: 10.1038/ni1363.Peer-Reviewed Original ResearchConceptsT cellsIntraepithelial lymphocytesT cell receptorMouse dendritic epidermal T-cellsOligoclonal T-cell receptorsDendritic epidermal T cellsEpidermal T cellsT cell repertoireT cell progenitorsCutaneous pathologyCell repertoireThymic stromaStromal determinantsLymphocyte repertoireCell receptorLymphocytesCell progenitorsHeritable defectsCellsIntraepithelialAgonistsMicePathologyPhysiological useStromaEnvironmentally Responsive and Reversible Regulation of Epidermal Barrier Function by γδ T Cells
Girardi M, Lewis JM, Filler RB, Hayday AC, Tigelaar RE. Environmentally Responsive and Reversible Regulation of Epidermal Barrier Function by γδ T Cells. Journal Of Investigative Dermatology 2006, 126: 808-814. PMID: 16439970, DOI: 10.1038/sj.jid.5700120.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsT cellsGammadelta T cell-deficient miceLimited T cell receptor diversityT cell-deficient miceBarrier functionTCRdelta-/- miceT-cell receptor diversityEpidermal T cellsT cell compartmentΓδ T cellsBarrier function defectsEpidermal barrier functionTransepidermal water lossPathogen-specific antigensCutaneous inflammationCutaneous neoplasiaDeficient miceGammadelta cellsFunction defectsCutaneous physiologyFetal thymocytesEpidermal barrierHydration statusReceptor diversity
2003
Anti‐inflammatory effects in the skin of thymosin‐β4 splice‐variants
Girardi M, Sherling MA, Filler RB, Shires J, Theodoridis E, Hayday AC, Tigelaar RE. Anti‐inflammatory effects in the skin of thymosin‐β4 splice‐variants. Immunology 2003, 109: 1-7. PMID: 12709011, PMCID: PMC1782938, DOI: 10.1046/j.1365-2567.2003.01616.x.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsContact dermatitisAnti-inflammatory effectsEpidermal T cellsAnti-inflammatory propertiesIrritant contact dermatitisAllergic contact dermatitisAnti-inflammatory activityT cell receptorNeutrophil infiltrationNeutrophilic infiltrationCutaneous inflammationLocal inflammationLymphoid tissueT cellsMurine skinCellular activationInflammationDermatitisThymosin β4SkinIELInfiltrationUnknown bioactivitiesGene expression
2002
Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation
Girardi M, Lewis J, Glusac E, Filler RB, Geng L, Hayday AC, Tigelaar RE. Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation. Journal Of Experimental Medicine 2002, 195: 855-867. PMID: 11927630, PMCID: PMC2193718, DOI: 10.1084/jem.20012000.Peer-Reviewed Original ResearchConceptsT cell receptorEpidermal T cellsT cellsIrritant dermatitisGammadelta T-cell receptorT cell-mediated inflammationCell-mediated inflammationSystemic inflammatory reactionIrritant contact dermatitis reactionsΓδ T cellsGammadelta T cellsContact dermatitis reactionsCutaneous inflammationIEL subsetsChronic dermatitisFunctional impairmentInflammatory reactionDermatitis reactionsEpithelial interfaceCell subpopulationsCell receptorMiceMouse strainsDermatitisSingle autosomal recessive gene