2004
Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma
Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma. Journal Of Investigative Dermatology 2004, 122: 699-706. PMID: 15086556, DOI: 10.1111/j.0022-202x.2004.22342.x.Peer-Reviewed Original ResearchConceptsT cell responsesImmune responseCell responsesProtective anti-tumor effectTransplantable squamous cell carcinomaT cell-deficient miceAlphabeta T cell responsesCell-deficient miceT cell activityCellular immune responsesSquamous cell carcinomaΑβ T cell responsesSquamous cell carcinoma linesAlphabeta T cellsAnti-tumor effectsNK receptorsCell carcinomaT cellsFocal necrosesRAE-1Protective potentialTumor growthProtective responseStromal bedCell activity
2003
The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer
Girardi M, Glusac E, Filler RB, Roberts SJ, Propperova I, Lewis J, Tigelaar RE, Hayday AC. The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer. Journal Of Experimental Medicine 2003, 198: 747-755. PMID: 12953094, PMCID: PMC2194182, DOI: 10.1084/jem.20021282.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogensDisease Models, AnimalHematopoietic Stem CellsLiverMiceMice, KnockoutNeoplasm StagingPapillomaReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSkin NeoplasmsTetradecanoylphorbol AcetateTime FactorsT-LymphocytesConceptsAlphabeta T cellsT cellsT cell receptorGammadelta cellsCell receptorProgression of papillomasResident intraepithelial lymphocytesSquamous cell carcinomaT-cell typeTwo-stage regimenMurine T cell receptorInduction of papillomasIntraepithelial lymphocytesCutaneous malignanciesCell carcinomaFVB miceHost protectionSkin cancerLow dosesCarcinomaPapillomasTumor promoterNonredundant contributionsModifier genesProgressionγδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity
Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity. Journal Of Experimental Medicine 2003, 198: 433-442. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, CellularInterferon-gammaInterleukin-12Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationNeoplasms, ExperimentalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTransplantation ChimeraTumor Cells, CulturedConceptsGammadelta T cellsAlphabeta T cellsT cellsTumor immunityIFN-gammaHigh incidenceGammadelta T cell-deficient miceImpaired IFN-gamma productionT cell-deficient miceTumor developmentCell-deficient miceBone marrow chimerasΓδ T cellsIFN-gamma productionSite of tumorT cell repertoireWild-type miceChemical carcinogen methylcholanthreneMelanoma cell line B16B16 melanoma cellsTumor lysateCarcinogen methylcholanthreneTumor immunosurveillanceInterferon γSuch mice