2017
Architecture, Function, and Assembly of the Mouse Visual System
Seabrook TA, Burbridge TJ, Crair MC, Huberman AD. Architecture, Function, and Assembly of the Mouse Visual System. Annual Review Of Neuroscience 2017, 40: 499-538. PMID: 28772103, DOI: 10.1146/annurev-neuro-071714-033842.Peer-Reviewed Original ResearchConceptsSpecific cell typesMammalian central nervous systemGenetic perturbationsModel speciesCell typesCausal testingSpeciesVivo labelingBroad scaleVisual system structuresManipulation of neuronsSensory systemsCentral nervous systemVisual circuitryPowerful toolNervous systemLarge cadreHumansMouse visual systemAdditional experimentationPathwayFunctionConvenient sizeAssemblyVisual system
2016
Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits
Xu HP, Burbridge TJ, Ye M, Chen M, Ge X, Zhou ZJ, Crair MC. Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits. Journal Of Neuroscience 2016, 36: 3871-3886. PMID: 27030771, PMCID: PMC4812142, DOI: 10.1523/jneurosci.3549-15.2016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAmacrine CellsAnimalsAnimals, NewbornCalciumCholera ToxinCholine O-AcetyltransferaseCholinergic AgentsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsIn Vitro TechniquesMiceMice, TransgenicPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsVesicular Glutamate Transport Protein 1Visual PathwaysConceptsEye-specific segregationVisual circuit developmentStarburst amacrine cellsStage III retinal wavesRetinal ganglion cellsRetinal wavesAmacrine cellsGlutamatergic wavesGanglion cellsSpontaneous activityVisual circuitsStage IICircuit developmentHigher-order visual areasNicotinic acetylcholine receptorsRetinal cell typesMammalian visual systemAcetylcholine receptorsΒ2-nAChRsVisual areasPatterned activityPatterning of activityΒ2 subunitCell typesCells
2014
Laminar and Temporal Expression Dynamics of Coding and Noncoding RNAs in the Mouse Neocortex
Fertuzinhos S, Li M, Kawasawa YI, Ivic V, Franjic D, Singh D, Crair M, Šestan N. Laminar and Temporal Expression Dynamics of Coding and Noncoding RNAs in the Mouse Neocortex. Cell Reports 2014, 6: 938-950. PMID: 24561256, PMCID: PMC3999901, DOI: 10.1016/j.celrep.2014.01.036.Peer-Reviewed Original ResearchConceptsTemporal expression dynamicsExpression dynamicsDistinct biological processesGene coexpression networksSpecific spatiotemporal expressionSmall RNAsNoncoding RNAsTranscriptional differencesTranscriptional eventsSplicing patternsCoexpression networkMRNA interactionsPotential miRNATranscriptional overlapDeep sequencingBiological processesSpatiotemporal expressionMouse neocortexCell typesTranscriptsStudies of neurodevelopmentIntegrated viewTemporal dynamicsCharacteristic setTranscriptome