2025
The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.Peer-Reviewed Original ResearchConceptsDaily smokingDaily cigarette smokingChronic painDevelopment of painCigarette smokingTobacco smokePopulation Assessment of Tobacco and Health StudyBaseline painAlternative tobacco product usePersistent painTobacco product useDevelopment of persistent painYears of longitudinal dataHealth StudyTobacco useNo/low painPreventable causeSmoking outcomesBidirectional relationshipSurvival analysisSmokingPopulation AssessmentAge categoriesIncreased riskSurvey population
2023
Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence
Palmisano A, Schwartz E, Gueorguieva R, Sofuoglu M. Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence. Nicotine & Tobacco Research 2023, 26: 324-332. PMID: 37565294, PMCID: PMC10882440, DOI: 10.1093/ntr/ntad135.Peer-Reviewed Original ResearchSevere nicotine dependenceNicotine dependenceCotinine levelsChildhood traumaWithdrawal severityOvernight abstinenceSmoking outcomesAbuse groupHigher plasma cotinine levelsTrauma subscalesPlasma cotinine levelsNegative affectSmoking-related outcomesPublic health interventionsStudies of adultsTobacco use outcomesSevere childhood traumaChildhood trauma historyCessation interventionsMinimal groupsSmoking riskBiochemical assessmentSmoking behaviorSmoking urgesPlasma cortisol
2022
Progesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence
Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Epperson CN. Progesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence. Nicotine & Tobacco Research 2022, 24: 1898-1905. PMID: 35713950, PMCID: PMC9653080, DOI: 10.1093/ntr/ntac146.Peer-Reviewed Original ResearchConceptsBrief abstinenceNegative affectNicotine withdrawalNicotine use disorderUse disordersFemale smokersNeural measuresFinal drug administrationSmoking cuesSmoking-related outcomesNeural responsesEffect of progesteroneSmoking urgesMood statesSex-dependent effectsSmoking outcomesNicotine effectsDrug AdministrationAbstinence periodSubjective effectsNicotine dependenceAbstinenceMain effectSignificant sexPlacebo-controlled crossover study
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