2025
Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective
Ameral V, Sofuoglu M, Kelly M. Nicotine e-cigarettes for smoking cessation: a clinical pharmacology perspective. Expert Review Of Clinical Pharmacology 2025, ahead-of-print: 1-8. PMID: 40047379, DOI: 10.1080/17512433.2025.2472837.Peer-Reviewed Original ResearchSmoking cessationE-cigarettesEvidence-based clinical guidelinesEfficacy of e-cigarettesBenefits of e-cigarettesSmoking cessation treatmentHarm reduction optionsHarm reduction principlesNicotine replacement therapyNicotine e-cigarettesQuality of lifeIncreased life expectancyNicotine useCessation treatmentClinical guidelinesNicotineSmokingLife expectancyCigarette smokingClinical pharmacology perspectivePharmacological perspectiveClinical practiceHigh riskLong-term effectsReplacement therapy
2012
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine
Sofuoglu M, Herman AI, Nadim H, Jatlow P. Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine. Neuropsychopharmacology 2012, 37: 1509-1516. PMID: 22334123, PMCID: PMC3327855, DOI: 10.1038/npp.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarbon MonoxideChi-Square DistributionChromatography, High Pressure LiquidCotinineDose-Response Relationship, DrugHeart RateHumansHydrocortisoneInjections, IntravenousMaleMiddle AgedNicotineNicotinic AgonistsSingle-Blind MethodSubstance Withdrawal SyndromeTandem Mass SpectrometryTime FactorsYoung AdultConceptsHigher nicotine metabolite ratioNicotine metabolite ratioHeart rate increaseCessation treatmentNicotine clearanceOvernight abstinenceGood drug effectBlood pressure measuresDiastolic blood pressure measuresEffects of nicotinePoor treatment responseNicotine dependence scoresTreatment-seeking smokersGreater heart rate increaseIntravenous dosesNicotine patchPoor outcomeNicotine rewardDrug likingFagerstrom TestTreatment outcomesIntravenous nicotineTreatment responseCigarette cravingHeart rate
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