2024
Development and Psychometric Evaluation of a Novel Measure of Nicotine E-cigarette Withdrawal for Use With Adolescents and Young Adults
Morean M, Rajeshkumar L, Krishnan-Sarin S. Development and Psychometric Evaluation of a Novel Measure of Nicotine E-cigarette Withdrawal for Use With Adolescents and Young Adults. Nicotine & Tobacco Research 2024, ntae095. PMID: 38695371, DOI: 10.1093/ntr/ntae095.Peer-Reviewed Original ResearchNicotine withdrawalNegative affectWithdrawal ScaleE-cigarette dependenceCessation attemptsRetrospective measuresPsychometric evaluationYoung adultsIncremental validity analysesNicotine product usePreliminary psychometric evaluationPsychometrically-sound measureScalar measurement invarianceE-cigarette useE-cigarettesNicotine e-cigarettesWithdrawal itemsWithdrawal scoresMeasurement invariancePsychometric propertiesConcurrent validityInternal reliabilityPhysical symptomsNicotineNegative physical symptoms
2014
FKBP5 variation is associated with the acute and chronic effects of nicotine
Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanBlood PressureDiagnostic and Statistical Manual of Mental DisordersGene FrequencyGenotypeHeart RateHumansHydrocortisoneInjections, IntravenousNicotineNicotinic AgonistsRNARNA, MessengerSmokingSubstance Withdrawal SyndromeTacrolimus Binding ProteinsWhite PeopleConceptsNicotine withdrawalFKBP5 mRNA expressionNegative drug effectsHeart rateIndependent cohortDrug effectsMRNA expressionMinor alleleChronic behavioral effectsEffects of nicotineStress hormone regulationLower cortisol levelsWarrants further investigationSevere nicotine withdrawalCurrent smokersBlood pressureHeavy smokersQuit attemptsHR responseSmoking behaviorCortisol responseCortisol levelsLower subjective ratingsSmokersChronic effects