Shear-mediated ALK5 expression regulates endothelial activation
Pang K, Ghim M, Sarathchandra P, Warboys C, Yacoub M, Chester A, Weinberg P. Shear-mediated ALK5 expression regulates endothelial activation. Biochemical And Biophysical Research Communications 2022, 642: 90-96. PMID: 36566567, DOI: 10.1016/j.bbrc.2022.12.058.Peer-Reviewed Original ResearchConceptsBlood flowCalcific aortic valve diseaseAortic valve diseaseHuman umbilical vein endothelial cell monolayersEndothelial-leukocyte adhesionALK5 kinase activityCardiovascular disease pathologyPotential therapeutic targetAortic valve tissueEndothelial dysfunctionValve diseaseALK5 expressionEndothelial activationFurther mechanistic investigationsEndothelial cell monolayersPorcine aortic valve tissuePathophysiological changesOvert diseaseAortic sidePathological changesTherapeutic targetVentricular sideLeukocyte adhesionMonocyte adhesionSmad2 phosphorylation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply