2025
Cardiovascular Risk Factors in Myeloproliferative Neoplasms: Associations with Survival and Thrombotic Outcomes
How J, Leiva O, Redd R, Marneth A, DeAngelo D, Dieli-Conwright C, El-Jawahri A, Kamaz B, Kim C, Lindsley C, Luskin M, Stahl M, Wazir M, Weeks L, Hobbs G. Cardiovascular Risk Factors in Myeloproliferative Neoplasms: Associations with Survival and Thrombotic Outcomes. Blood Vessels Thrombosis & Hemostasis 2025, 100051. DOI: 10.1016/j.bvth.2025.100051.Peer-Reviewed Original ResearchMyeloproliferative neoplasm patientsCardiovascular risk factorsEssential thrombocythemiaMyeloproliferative neoplasmsPolycythemia veraThrombotic outcomesThrombotic riskRisk factorsDiagnosis of hematological malignanciesMyeloproliferative neoplasm subtypeIncreased risk of deathType 2 diabetes mellitusMyeloproliferative neoplasms diagnosisRetrospective cohort analysisSex-matched controlsManaging cardiovascular risk factorsAssociated with survivalImprove patient morbidityRisk of deathMF patientsHematologic malignanciesMPN diagnosisPatient morbidityDana-FarberArterial/venous thrombosis
2023
No Increased Incidence of Bleeding in Essential Thrombocythemia Patients with Extreme Thrombocytosis
Venkat R, Redd R, Aryee M, Marneth A, Kamaz B, Kim C, Wazir M, Weeks L, Stahl M, DeAngelo D, Lindsley C, Luskin M, Hobbs G, How J. No Increased Incidence of Bleeding in Essential Thrombocythemia Patients with Extreme Thrombocytosis. Blood 2023, 142: 1839. DOI: 10.1182/blood-2023-187530.Peer-Reviewed Original ResearchClinically relevant non-major bleedingTreated with cytoreductionYear cumulative incidenceIncidence of bleedingCumulative incidence of bleedingEssential thrombocythemiaRate of bleedingCumulative incidenceDisease coursePlatelet countThrombotic riskET patientsDiabetes mellitusInitiation of cytoreductive therapyMultivariate analysisActivity levelsIncidence rate of bleedingMultivariable Fine-Gray modelsLow riskRisk factorsInternational Prognostic Score of thrombosisET diagnosisCumulative incidence of thrombosisInternational Society on ThrombosisIncreased incidence of bleeding
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