2025
Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections
Huang C, Laurent-Rolle M, Grove T, Hsu J. Interferon-Stimulated Genes and Immune Metabolites as Broad-Spectrum Biomarkers for Viral Infections. Viruses 2025, 17: 132. PMID: 39861921, PMCID: PMC11768885, DOI: 10.3390/v17010132.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInterferon-stimulated genesReceiver operating characteristicViral infectionAntiviral functionType I interferonTarget various stagesIFN-II interferonViral replicationClinical practiceDiagnostic potentialClinical applicationProtein levelsBiomarkersImmune defenseInfectionViral pathogensMetabolitesBroad spectrumGenesEffective translation
2009
NS5 of Dengue Virus Mediates STAT2 Binding and Degradation
Ashour J, Laurent-Rolle M, Shi PY, GarcĂa-Sastre A. NS5 of Dengue Virus Mediates STAT2 Binding and Degradation. Journal Of Virology 2009, 83: 5408-5418. PMID: 19279106, PMCID: PMC2681973, DOI: 10.1128/jvi.02188-08.Peer-Reviewed Original ResearchConceptsDengue virusInnate immune responseInnate antiviral responseImmune responseInfection resultsIFN responseAntiviral responseDENV proteinsLevel of expressionAntiviral therapeuticsDENV genomeDecreased levelsInterferonPotential targetProtein levelsViral pathogensHost proteasesReduced levelsProteasome activityMultiple mechanismsVirusFacilitate infectionNovel mechanismViral polypeptidesNS5
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