2024
Comprehensive Assessment of Inactivation Methods for Madariaga Virus
Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Comprehensive Assessment of Inactivation Methods for Madariaga Virus. Viruses 2024, 16: 206. PMID: 38399982, PMCID: PMC10892135, DOI: 10.3390/v16020206.Peer-Reviewed Original ResearchConceptsEastern equine encephalitis virusMadariaga virusMethod of inactivationInactivation methodSelective agentNorth American strainsEEEV strainsEquine encephalitis virusTRIzol LSAmino acid levelsAmerican strainsEncephalitis virusAcid levelsTRIzolInfected cellsVirusFormalinInactivationPathogensPublic health threatInfected supernatantStrain
2009
NS5 of Dengue Virus Mediates STAT2 Binding and Degradation
Ashour J, Laurent-Rolle M, Shi PY, García-Sastre A. NS5 of Dengue Virus Mediates STAT2 Binding and Degradation. Journal Of Virology 2009, 83: 5408-5418. PMID: 19279106, PMCID: PMC2681973, DOI: 10.1128/jvi.02188-08.Peer-Reviewed Original ResearchConceptsDengue virusInnate immune responseInnate antiviral responseImmune responseInfection resultsIFN responseAntiviral responseDENV proteinsLevel of expressionAntiviral therapeuticsDENV genomeDecreased levelsInterferonPotential targetProtein levelsViral pathogensHost proteasesReduced levelsProteasome activityMultiple mechanismsVirusFacilitate infectionNovel mechanismViral polypeptidesNS5