Featured Publications
Acetyl-methyllysine marks chromatin at active transcription start sites
Lu-Culligan W, Connor L, Xie Y, Ekundayo B, Rose B, Machyna M, Pintado-Urbanc A, Zimmer J, Vock I, Bhanu N, King M, Garcia B, Bleichert F, Simon M. Acetyl-methyllysine marks chromatin at active transcription start sites. Nature 2023, 622: 173-179. PMID: 37731000, PMCID: PMC10845139, DOI: 10.1038/s41586-023-06565-9.Peer-Reviewed Original ResearchConceptsPost-translational modificationsLysine residuesActive transcription start sitesTranscription start siteRange of speciesChromatin biologyChromatin proteinsLysine methylationActive chromatinProteins BRD2Transcriptional initiationLysine acetylationHistone H4Start siteMammalian tissuesHuman diseasesSame residuesMethylationAcetylationChromatinResiduesProteinBiological signalsHistonesBRD2
2025
Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination
Wu L, Yadavalli A, Senigl F, Matos-Rodrigues G, Xu D, Pintado-Urbanc A, Simon M, Wu W, Nussenzweig A, Schatz D. Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination. Molecular Cell 2025 PMID: 40049160, DOI: 10.1016/j.molcel.2025.02.007.Peer-Reviewed Original ResearchRNA polymerase IITranscription-coupled nucleotide excision repairActivation-induced deaminaseClass switch recombinationSomatic hypermutationRNA polymerase II elongation complexDownstream of transcription start sitesRNA polymerase II transcriptionTranscription start siteSwitch recombinationMammalian B cellsImmunoglobulin (Ig) genesDNA cytidine deaminaseNucleotide excision repairPolymerase IISerine 5Transcribed genesTranscription elongationElongation complexStart siteGenetic screeningELOF1Excision repairTranscriptionProximity partners
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