2025
Therapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy
Iizuka Y, Sasaki M, Terada K, Sakai T, Nagaoka Y, Fukumura S, Kocsis J, Tsugawa T, Honmou O. Therapeutic Efficacy of Mesenchymal Stem Cells in Modulating Oxidative Stress in Puromycin-Induced Nephropathy. Pathophysiology 2025, 32: 19. PMID: 40407599, PMCID: PMC12101160, DOI: 10.3390/pathophysiology32020019.Peer-Reviewed Original ResearchMesenchymal stem cellsQuantitative real-time reverse-transcription PCRMSC infusionNephrotic syndromePAN injectionModulating oxidative stressIntravenously infused mesenchymal stem cellsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsInfused mesenchymal stem cellsOxidative stressEfficacy of mesenchymal stem cellsPodocyte structureSprague-Dawley ratsGFP-labeled mesenchymal stem cellsTherapeutic efficacy of mesenchymal stem cellsOxidative stress modulationPotential therapeutic approachReal-time reverse-transcription PCRCreatinine levelsReduce proteinuriaIntravenous infusionUrinary albuminTherapeutic efficacyIntravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury
Hirota R, Sasaki M, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury. Molecular Brain 2025, 18: 35. PMID: 40241097, PMCID: PMC12004759, DOI: 10.1186/s13041-025-01210-0.Peer-Reviewed Original ResearchConceptsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsSpinal cord injuryIntravenous infusionMesenchymal stem cellsRubrospinal tractCircuit reorganizationInfused mesenchymal stem cellsCord injuryNeural circuit reorganizationNeuronal tracing techniquesSignal intensityInjury siteFunctional improvementSpontaneous recoveryStem cellsDescending tractsAxonal connectionsInjuryAxonal growthTractAxonal network
2024
Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia.
Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S, Kocsis J, Honmou O. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal Of Neurosurgery 2024, 142: 684-692. PMID: 39454218, DOI: 10.3171/2024.6.jns241111.Peer-Reviewed Original ResearchInfusion of mesenchymal stem cellsMiddle cerebral artery occlusionMiddle cerebral artery occlusion inductionMesenchymal stem cellsCorpus callosumSystemic infusion of mesenchymal stem cellsMultiple infusionsAcute phaseMesenchymal stem cell infusionCerebral ischemiaStem cellsMultiple intravenous infusionsRat model of cerebral ischemiaHigh-dose infusionPermanent middle cerebral artery occlusionIschemic lesion volumeModels of cerebral ischemiaCC thicknessRandomized clinical trialsCerebral artery occlusionNeural tractsAcute cerebral strokeFunctional recovery outcomesMRI diffusion tensor imagingMSC-3Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series
Hirota R, Sasaki M, Iyama S, Kurihara K, Fukushi R, Obara H, Oshigiri T, Morita T, Nakazaki M, Namioka T, Namioka A, Onodera R, Kataoka-Sasaki Y, Oka S, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Okuma Y, Kondo R, Aichi R, Ohmatsu S, Kawashima N, Ito Y, Kobune M, Takada K, Ishiai S, Ogata T, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. Journal Of Clinical Medicine 2024, 13: 6072. PMID: 39458022, PMCID: PMC11509003, DOI: 10.3390/jcm13206072.Peer-Reviewed Original ResearchAmerican Spinal Injury Association Impairment ScaleSevere spinal cord injuryMesenchymal stem cell infusionAutologous mesenchymal stem cellsIntravenous infusionCase seriesMesenchymal stem cellsQuality of lifeAuto-serumSpinal cord injuryFunctional improvementChronic spinal cord injury patientsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsCord injurySpinal Cord Independence Measure IIIAmerican Spinal Injury Association Impairment Scale grades CSpinal cord injury patientsChronic SCI patientsClassification of Spinal Cord InjuryNeurological Classification of Spinal Cord InjurySignificant functional improvementAssociation Impairment ScaleInternational Standards for Neurological Classification of Spinal Cord InjuryIntravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients
Yamaki T, Oka S, Iyama S, Sasaki M, Onodera R, Kataoka-Sasaki Y, Namioka T, Namioka A, Nakazaki M, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Yamaguchi M, Fukino M, Takazawa T, Hayasaka M, Owaku T, Funakura M, Onodera S, Ito Y, Kobune M, Kato J, Ishiai S, Kocsis J, Odaki M, Iwadate Y, Kobayashi S, Honmou O. Intravenous infusion of auto-serum-expanded autologous mesenchymal stem cells into chronic severe brain injury patients. Interdisciplinary Neurosurgery 2024, 36: 101927. DOI: 10.1016/j.inat.2023.101927.Peer-Reviewed Original ResearchSevere brain injury patientsAutologous mesenchymal stem cellsBrain injury patientsIntravenous infusionMesenchymal stem cellsAdverse eventsInjury patientsInfused mesenchymal stem cellsHealth Stroke ScaleSerious adverse eventsFugl-Meyer AssessmentInitial case seriesBrain metabolic activityStem cellsMSC infusionStroke ScaleNeurological deteriorationBarthel IndexCase seriesCNS tumorsNeurological functionFunctional statusFunctional improvementChronic patientsPlacebo effect
2023
Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
Terada K, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Iizuka Y, Sakai T, Fukumura S, Tsugawa T, Kocsis J, Honmou O. Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury. Pediatric Research 2023, 94: 1921-1928. PMID: 37422495, DOI: 10.1038/s41390-023-02717-9.Peer-Reviewed Original ResearchConceptsPerinatal brain injuryBrain injuryMesenchymal stem cellsIntravenous infusionVehicle groupBrain volumeTherapeutic efficacyInfused mesenchymal stem cellsLeft common carotid arteryHistological analysisNon-ischemic hemispherePostnatal day 7Common carotid arteryEmbryonic day 18Stem cellsHypoxia-ischemiaMSC infusionPreterm infantsGABAergic cellsNeurological functionSignificant complicationsCortical synapsesFunctional improvementCarotid arteryIntravenous administrationMesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
Hirota R, Sasaki M, Honmou O, Yamashita T. Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects. Spine Surgery And Related Research 2023, 7: 319-326. PMID: 37636138, PMCID: PMC10447197, DOI: 10.22603/ssrr.2022-0234.Peer-Reviewed Original ResearchSpinal cord injuryMesenchymal stem cellsCord injuryMesenchymal stem cell transplantationSevere spinal cord injuryCentral nervous system diseaseMotor function recoveryStem cell transplantationNervous system diseasesSCI modelCell transplantationFunction recoveryIntravenous infusionMSC transplantationMotor functionRat modelIntravenous administrationSystem diseasesBone marrowSCI researchTransplantationInjuryRecent updatesStem cellsCell typesInvestigation of the therapeutic efficacy of bone marrow mesenchymal stem cells for neuropathic pain
Fukushi R, Sasaki M, Yamashita T, Honmou O. Investigation of the therapeutic efficacy of bone marrow mesenchymal stem cells for neuropathic pain. Brain And Spine 2023, 3: 102427. DOI: 10.1016/j.bas.2023.102427.Peer-Reviewed Original Research
2022
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model
Maeda S, Kawamura T, Sasaki M, Shimamura K, Shibuya T, Harada A, Honmou O, Sawa Y, Miyagawa S. Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. Scientific Reports 2022, 12: 16986. PMID: 36216855, PMCID: PMC9551049, DOI: 10.1038/s41598-022-18485-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowDisease Models, AnimalGreen Fluorescent ProteinsHindlimbInfusions, IntravenousIschemiaLower ExtremityMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeovascularization, PhysiologicPerfusionPeripheral Vascular DiseasesRatsRats, Sprague-DawleyVascular Endothelial Growth Factor AConceptsIntravenous infusionVascular endothelial growth factorMesenchymal stem cellsTissue perfusionHindlimb ischemia modelRat hindlimb ischemia modelIschemia modelCell groupsFemoral artery removalIschemia animal modelStem cellsHindlimb muscle tissueBone marrow-derived mesenchymal stem cellsEndothelial growth factorMarrow-derived mesenchymal stem cellsMSC infusionHistological findingsIschemic limbsHindlimb ischemiaCell delivery methodsIschemic hindlimbSprague-DawleyCapillary densityAnimal modelsInfusionEnhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury
Hirota R, Sasaki M, Kataoka-Sasaki Y, Oshigiri T, Kurihara K, Fukushi R, Oka S, Ukai R, Yoshimoto M, Kocsis JD, Yamashita T, Honmou O. Enhanced Network in Corticospinal Tracts after Infused Mesenchymal Stem Cells in Spinal Cord Injury. Journal Of Neurotrauma 2022, 39: 1665-1677. PMID: 35611987, PMCID: PMC9734021, DOI: 10.1089/neu.2022.0106.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCorticospinal tractMesenchymal stem cellsCord injurySpinal cordSpontaneous recoveryInfused mesenchymal stem cellsLimited spontaneous recoveryDorsal corticospinal tractLateral corticospinal tractStem cellsCST pathwayCST projectionsSCI inductionMSC infusionAxonal sproutingFunctional recoveryLateral funiculusIntravenous infusionAxonal tracerLesion coreMotor pathwaysFunctional improvementCircuit reorganizationMajor projectionsIntravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial
Oka S, Yamaki T, Sasaki M, Ukai R, Takemura M, Yokoyama T, Kataoka-Sasaki Y, Onodera R, Ito YM, Kobayashi S, Kocsis JD, Iwadate Y, Honmou O. Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial. JMIR Research Protocols 2022, 11: e37898. PMID: 35793128, PMCID: PMC9301565, DOI: 10.2196/37898.Peer-Reviewed Original ResearchChronic brain injuryAutologous mesenchymal stem cellsSpinal cord injuryINTERNATIONAL REGISTERED REPORT IDENTIFIERBrain injuryIntravenous infusionRankin Scale gradesCord injuryMesenchymal stem cellsClinical trialsScale gradeTherapeutic efficacyJapan Medical Association CenterSapporo Medical University HospitalInvestigator-initiated clinical trialsModified Rankin Scale gradesOpen-label trialPhase 2 studyPhase 2 trialMedical University HospitalCause of disabilityMotor vehicle accidentsPotential therapeutic efficacyProportion of casesStem cellsThe Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study
Maeda-Yamamoto M, Honmou O, Sasaki M, Haseda A, Kagami-Katsuyama H, Shoji T, Namioka A, Namioka T, Magota H, Oka S, Kataoka-Sasaki Y, Ukai R, Takemura M, Nishihira J. The Impact of Purple-Flesh Potato (Solanum tuberosum L.) cv. “Shadow Queen” on Minor Health Complaints in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2022, 14: 2446. PMID: 35745176, PMCID: PMC9227939, DOI: 10.3390/nu14122446.Peer-Reviewed Original ResearchConceptsMinor health complaintsHealth complaintsHealthy adultsMesenchymal stem cellsMSC countPlacebo groupWeeks 0Psychological stress responsesHealthy subjectsIntake periodStress responseAdverse effectsComplaintsTest groupStem cellsStudy determinesAdultsGroupCountPurple potatoesResponsePlaceboIrritabilityIntakeIngestion
2021
Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia.
Takemura M, Sasaki M, Kataoka-Sasaki Y, Kiyose R, Nagahama H, Oka S, Ukai R, Yokoyama T, Kocsis J, Ueba T, Honmou O. Repeated intravenous infusion of mesenchymal stem cells for enhanced functional recovery in a rat model of chronic cerebral ischemia. Journal Of Neurosurgery 2021, 137: 402-411. PMID: 34861644, DOI: 10.3171/2021.8.jns21687.Peer-Reviewed Original ResearchMiddle cerebral artery occlusionInduction of MCAOCorpus callosumMesenchymal stem cellsChronic phaseMotor functionRat modelWeek 8Vehicle groupInterhemispheric connectionsAdministration of MSCsChronic cerebral ischemia modelNeural connectionsChronic stroke modelCerebral artery occlusionChronic cerebral ischemiaIschemic lesion volumeLong-term disabilityGreater functional improvementCerebral ischemia modelEnhanced functional recoveryAnti-neurofilament antibodiesDiffusion tensorSingle systemic infusionStem cellsPossible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat
Tabata H, Sasaki M, Kataoka-Sasaki Y, Shinkai N, Ichihara K, Masumori N, Kocsis JD, Honmou O. Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. BMC Urology 2021, 21: 156. PMID: 34774029, PMCID: PMC8590770, DOI: 10.1186/s12894-021-00923-3.Peer-Reviewed Original ResearchConceptsHunner-type ICBladder pain syndromeAnti-inflammatory pathwayMSC groupMesenchymal stem cellsPain syndromeAnimal modelsToll-like receptor 7 agonistTherapeutic efficacyBehavior testsRight external jugular veinFemale Sprague-Dawley ratsGFP-positive mesenchymal stem cellsReceptor 7 agonistChronic pelvic painAnti-inflammatory effectsEfficacious treatment optionExperimental animal modelsSprague-Dawley ratsExternal jugular veinReal-time polymerase chain reactionMRNA expression levelsPositive mesenchymal stem cellsStem cellsHunner lesionsIntravenous Infusion of Mesenchymal Stem Cells Promotes the Survival of Random Pattern Flaps in Rats
Nakagawa T, Sasaki M, Kataoka-Sasaki Y, Yotsuyanagi T, Radtke C, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Promotes the Survival of Random Pattern Flaps in Rats. Plastic & Reconstructive Surgery 2021, 148: 799-807. PMID: 34550936, DOI: 10.1097/prs.0000000000008327.Peer-Reviewed Original ResearchConceptsMesenchymal stem cell groupStem cell groupIntravenous infusionRandom pattern flapsCell groupsMesenchymal stem cellsFlap survivalHistologic analysisRandom-pattern skin flapsBlood perfusionSurgical reconstruction optionsHigh expressionSkin flap survivalFibroblast growth factor-2 (FGF-2) mRNAQuantitative reverse transcription polymerase chain reactionStem cellsFlap survival areaReverse transcription-polymerase chain reactionSkin flap surgeryExperimental disease modelsSkin blood perfusionSkin flap modelSoft tissue defectsMasson's trichrome stainingMasson's trichrome staining resultsRepeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis. Molecular Brain 2021, 14: 76. PMID: 33962678, PMCID: PMC8103621, DOI: 10.1186/s13041-021-00787-6.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAdministration of MSCsSingle infusionMesenchymal stem cellsMotor functionGait abilityDisease progressionMotor neuronsRat modelLateral sclerosisBlood-spinal cord barrierSOD1G93A rat modelSpinal cord degenerateVehicle infusion groupHind limb functionALS rat modelStem cellsLimb functionVehicle infusionFatal disorderSurvival periodTherapeutic effectLocomotor activityInfusionProgressive deteriorationIntravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia
Kiyose R, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Magota H, Oka S, Ukai R, Takemura M, Yokoyama T, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia. World Neurosurgery 2021, 149: e160-e169. PMID: 33618048, DOI: 10.1016/j.wneu.2021.02.056.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowInfused mesenchymal stem cellsReperfusion therapyPermanent MCAOIntravenous infusionMesenchymal stem cellsTherapeutic efficacyTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelArterial spin labeling magnetic resonance imagingArtery occlusion modelStandard therapeutic strategyTransient MCAO modelCerebral blood flowBehavioral functionsNon-favorable outcomeRat model systemStem cellsMCAO groupStroke inductionAcute strokeCerebral ischemiaNeurologic functionInfusion groupMCAO modelIntravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series
Honmou O, Yamashita T, Morita T, Oshigiri T, Hirota R, Iyama S, Kato J, Sasaki Y, Ishiai S, Ito YM, Namioka A, Namioka T, Nakazaki M, Kataoka-Sasaki Y, Onodera R, Oka S, Sasaki M, Waxman SG, Kocsis JD. Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series. Clinical Neurology And Neurosurgery 2021, 203: 106565. PMID: 33667953, DOI: 10.1016/j.clineuro.2021.106565.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAmerican Spinal Injury Association Impairment ScaleMSC infusionAutologous mesenchymal stem cellsASIA CASIA DIntravenous infusionMesenchymal stem cellsSCI patientsFunctional statusFunctional improvementSpinal cord injury patientsSpinal Cord Independence MeasureASIA B patientsASIA C patientsPhase 2 studySerious adverse eventsCord injury patientsCurrent therapeutic optionsStem cellsASIA BASIA gradeC patientsNeurologic improvementAdverse events
2020
Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells
Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Hashi K, Kocsis JD, Honmou O. Prolonged lifespan in a spontaneously hypertensive rat (stroke prone) model following intravenous infusion of mesenchymal stem cells. Heliyon 2020, 6: e05833. PMID: 33392407, PMCID: PMC7773587, DOI: 10.1016/j.heliyon.2020.e05833.Peer-Reviewed Original ResearchHypertensive rat modelIntravenous infusionMesenchymal stem cellsRat modelGrowth factor-β1Forkhead box O1Stem cellsRenal dysfunctionMSC infusionSpontaneous hypertensionHypertensive ratsFactor-β1Survival rateTherapeutic efficacyInfusionBox O1Gene expression analysisHypertensionCellsDysfunctionMicrovascularKidneyRatsLiverExpression analysisIntravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia
Yasuda N, Sasaki M, Kataoka-Sasaki Y, Nagahama H, Kocsis JD, Kawaharada N, Honmou O. Intravenous delivery of mesenchymal stem cells protects both white and gray matter in spinal cord ischemia. Brain Research 2020, 1747: 147040. PMID: 32771405, DOI: 10.1016/j.brainres.2020.147040.Peer-Reviewed Original ResearchConceptsIschemic spinal cord injuryIntravenous infusionMesenchymal stem cellsDiffusion tensor imagingGray matterLocomotor functionTherapeutic efficacyHind limb locomotor functionGray matter volume reductionPreservation of microvasculatureSpinal cord ischemiaLeft subclavian arteryPersistent motor deficitsVehicle-treated groupSpinal cord injuryStem cellsBSCB functionISCI ratsAortic surgeryCord ischemiaDevastating complicationNeuronal lossSubclavian arteryMotor deficitsCord injury
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