2018
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus
Fukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGlutamate DecarboxylaseGreen Fluorescent ProteinsHippocampusInfusions, IntravenousLithiumMagnetic Resonance ImagingMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMuscarinic AgonistsNeuronsPhosphopyruvate HydratasePilocarpineRatsRats, Sprague-DawleyRats, TransgenicStatus EpilepticusTime FactorsConceptsAberrant mossy fiber sproutingMossy fiber sproutingStatus epilepticusNeuronal cell deathMesenchymal stem cellsMSC infusionIntravenous infusionRat modelCognitive functionMorris water maze testCognitive function preservationNumber of GAD67Water maze testVehicle-infused ratsMagnetic resonance imagingCell deathStem cellsSeizure frequencyFiber sproutingFunction preservationTimm stainingMaze testHippocampal neuronsImmunohistochemical stainingCognitive deterioration
2017
Detection of vulnerable neurons damaged by environmental insults in utero
Torii M, Sasaki M, Chang YW, Ishii S, Waxman SG, Kocsis JD, Rakic P, Hashimoto-Torii K. Detection of vulnerable neurons damaged by environmental insults in utero. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 2367-2372. PMID: 28123061, PMCID: PMC5338500, DOI: 10.1073/pnas.1620641114.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexElectroporationEmbryo, MammalianEthanolFemaleFlow CytometryGene Expression RegulationGenes, ReporterHeat Shock Transcription FactorsHeat-Shock ResponseLuminescent ProteinsMiceMice, TransgenicNeuronsNicotinePlasmidsPregnancyPrenatal Exposure Delayed EffectsResponse ElementsSuraminConceptsTransgenic reporter miceHeat shock factor 1 (HSF1) activationPrenatal exposureVulnerable neuronsPrognostic biomarkerReporter miceSusceptible individualsPostnatal disordersPostnatal lifeMultiple disordersNeuronsReporter assaysCellular damageEnvironmental insultsMiceHarmful agentsDisordersExposureTreatmentPhysical agentsFluorescence reporter systemPathogenesisSymptomsUteroAgents
2011
CNPase Expression in Olfactory Ensheathing Cells
Radtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD. CNPase Expression in Olfactory Ensheathing Cells. BioMed Research International 2011, 2011: 608496. PMID: 22174557, PMCID: PMC3228405, DOI: 10.1155/2011/608496.Peer-Reviewed Original ResearchConceptsOuter nerve layerOlfactory bulbNerve layerPeripheral nervesCNPase expressionOlfactory nerve axonsTransplantation of OECsSpinal cord injuryEndogenous Schwann cellsExpression of CNPaseTransplantation of olfactoryOlfactory Ensheathing CellsEnhanced green fluorescent proteinMyelination potentialCord injuryAxonal regenerationRegenerated axonsSchwann cellsTransgenic miceNerve axonsPeripheral myelinNerveCNPaseMyelinOECs
2008
Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury
Radtke C, Sasaki M, Lankford KL, Vogt PM, Kocsis JD. Potential of olfactory ensheathing cells for cell-based therapy in spinal cord injury. The Journal Of Rehabilitation Research And Development 2008, 45: 141-152. PMID: 18566933, DOI: 10.1682/jrrd.2007.03.0049.Peer-Reviewed Original ResearchConceptsSpinal cord injuryPeripheral nervous systemCentral nervous systemCord injuryAxonal regenerationNervous systemTreatment of SCIContusive spinal cord injuryPotential of olfactoryPermanent neurological deficitsSpecialized glial cellsCell therapy approachesCell transplantation approachesOEC biologyAxonal lossNeurological deficitsCell-based therapiesFunctional outcomeGlial cellsClinical studiesComplex lesionsMedicine cliniciansMacrophage activationTransplantation approachesInhibitory molecules
2005
Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells
Sasaki M, Hains BC, Lankford KL, Waxman SG, Kocsis JD. Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells. Glia 2005, 53: 352-359. PMID: 16288464, PMCID: PMC2605395, DOI: 10.1002/glia.20285.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzimidazolesCell CountCell SeparationCell SurvivalCell TransplantationEnzyme-Linked Immunosorbent AssayFluorescent DyesImage Processing, Computer-AssistedImmunohistochemistryIn Situ Nick-End LabelingMotor ActivityNeuronsOlfactory PathwaysPyramidal TractsRatsSpinal Cord InjuriesStilbamidinesConceptsCorticospinal tract neuronsSpinal cordTract neuronsNeuronal lossOEC transplantationDorsal spinal cord transectionPrimary motor cortexCortical projection neuronsSpinal cord transectionTransplantation of olfactoryRat spinal cordOlfactory Ensheathing CellsApoptotic cortical neuronsBDNF levelsNeuroprotective effectsCord transectionFunctional outcomeMotor cortexNeurotrophic moleculesProjection neuronsAxonal regenerationCortical neuronsInjury zoneTransplantationOECs