2017
Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas.
Wanibuchi M, Kataoka-Sasaki Y, Sasaki M, Oka S, Otsuka Y, Yamaguchi M, Ohnishi H, Ohtaki S, Noshiro S, Ookawa S, Mikami T, Mikuni N, Honmou O. Interleukin-13 receptor alpha 2 as a marker of poorer prognosis in high-grade astrocytomas. Journal Of Neurosurgical Sciences 2017, 62: 239-244. PMID: 28079349, DOI: 10.23736/s0390-5616.16.03793-0.Peer-Reviewed Original ResearchConceptsHigh-grade astrocytomasInterleukin-13 receptor alpha 2Overall survivalMIB-1 indexReceptor alpha 2Median OSPoor prognosisPatient ageCox proportional hazards modelWorld Health Organization gradeMedian overall survivalMedian survival benefitAdvanced patient ageAlpha 2Real-time quantitative reverse transcription polymerase chain reactionLow expression groupQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionProportional hazards modelTranscription-polymerase chain reactionExpression levelsSubset of casesParaffin-embedded glioma samplesHazard ratioSurvival benefitCo-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations
Noshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Ohnishi H, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Co-expression of tissue factor and IL-6 in immature endothelial cells of cerebral cavernous malformations. Journal Of Clinical Neuroscience 2017, 37: 83-90. PMID: 28087183, DOI: 10.1016/j.jocn.2016.12.023.Peer-Reviewed Original ResearchConceptsCerebral cavernous malformationsInterleukin-6Immature endothelial cellsTissue factorMRNA expression levelsEndothelial cellsCavernous malformationsSporadic cerebral cavernous malformationDistribution of TFExpression levelsNormal endothelial cellsClinical factorsPrognostic rolePathological findingsUnderlying pathologyOperative specimensMRNA expressionAssociation of TFAbnormal clustersMalformationsProgressive eventsMessenger RNACellsExpressionAssociation
2016
Biological relevance of tissue factor and IL-6 in arteriovenous malformations
Noshiro S, Mikami T, Kataoka-Sasaki Y, Sasaki M, Hashi K, Ohtaki S, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Biological relevance of tissue factor and IL-6 in arteriovenous malformations. Neurosurgical Review 2016, 40: 359-367. PMID: 27542852, DOI: 10.1007/s10143-016-0780-1.Peer-Reviewed Original ResearchConceptsInterleukin-6Vascular endothelial growth factor receptor 2Arteriovenous malformationsTissue factorControl tissuesMRNA expressionEndothelial cellsAbnormal endothelial cellsPlatelet-derived growth factor receptor betaGrowth factor receptor 2Growth factor receptor betaEndothelial growth factor receptor 2Factor receptor 2Distribution of TFSporadic arteriovenous malformationsNormal endothelial cellsMessenger RNAAsymptomatic groupSymptomatic groupClinical factorsPrognostic rolePathological findingsShunt bloodUnderlying pathologyOperative specimens