2023
Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
Terada K, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Oka S, Ukai R, Yokoyama T, Iizuka Y, Sakai T, Fukumura S, Tsugawa T, Kocsis J, Honmou O. Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury. Pediatric Research 2023, 94: 1921-1928. PMID: 37422495, DOI: 10.1038/s41390-023-02717-9.Peer-Reviewed Original ResearchConceptsPerinatal brain injuryBrain injuryMesenchymal stem cellsIntravenous infusionVehicle groupBrain volumeTherapeutic efficacyInfused mesenchymal stem cellsLeft common carotid arteryHistological analysisNon-ischemic hemispherePostnatal day 7Common carotid arteryEmbryonic day 18Stem cellsHypoxia-ischemiaMSC infusionPreterm infantsGABAergic cellsNeurological functionSignificant complicationsCortical synapsesFunctional improvementCarotid arteryIntravenous administration
2022
Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model
Maeda S, Kawamura T, Sasaki M, Shimamura K, Shibuya T, Harada A, Honmou O, Sawa Y, Miyagawa S. Intravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model. Scientific Reports 2022, 12: 16986. PMID: 36216855, PMCID: PMC9551049, DOI: 10.1038/s41598-022-18485-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowDisease Models, AnimalGreen Fluorescent ProteinsHindlimbInfusions, IntravenousIschemiaLower ExtremityMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNeovascularization, PhysiologicPerfusionPeripheral Vascular DiseasesRatsRats, Sprague-DawleyVascular Endothelial Growth Factor AConceptsIntravenous infusionVascular endothelial growth factorMesenchymal stem cellsTissue perfusionHindlimb ischemia modelRat hindlimb ischemia modelIschemia modelCell groupsFemoral artery removalIschemia animal modelStem cellsHindlimb muscle tissueBone marrow-derived mesenchymal stem cellsEndothelial growth factorMarrow-derived mesenchymal stem cellsMSC infusionHistological findingsIschemic limbsHindlimb ischemiaCell delivery methodsIschemic hindlimbSprague-DawleyCapillary densityAnimal modelsInfusion
2021
Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat
Tabata H, Sasaki M, Kataoka-Sasaki Y, Shinkai N, Ichihara K, Masumori N, Kocsis JD, Honmou O. Possible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat. BMC Urology 2021, 21: 156. PMID: 34774029, PMCID: PMC8590770, DOI: 10.1186/s12894-021-00923-3.Peer-Reviewed Original ResearchConceptsHunner-type ICBladder pain syndromeAnti-inflammatory pathwayMSC groupMesenchymal stem cellsPain syndromeAnimal modelsToll-like receptor 7 agonistTherapeutic efficacyBehavior testsRight external jugular veinFemale Sprague-Dawley ratsGFP-positive mesenchymal stem cellsReceptor 7 agonistChronic pelvic painAnti-inflammatory effectsEfficacious treatment optionExperimental animal modelsSprague-Dawley ratsExternal jugular veinReal-time polymerase chain reactionMRNA expression levelsPositive mesenchymal stem cellsStem cellsHunner lesionsIntravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia
Kiyose R, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Magota H, Oka S, Ukai R, Takemura M, Yokoyama T, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia. World Neurosurgery 2021, 149: e160-e169. PMID: 33618048, DOI: 10.1016/j.wneu.2021.02.056.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowInfused mesenchymal stem cellsReperfusion therapyPermanent MCAOIntravenous infusionMesenchymal stem cellsTherapeutic efficacyTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelArterial spin labeling magnetic resonance imagingArtery occlusion modelStandard therapeutic strategyTransient MCAO modelCerebral blood flowBehavioral functionsNon-favorable outcomeRat model systemStem cellsMCAO groupStroke inductionAcute strokeCerebral ischemiaNeurologic functionInfusion groupMCAO modelFocal brainstem infarction in the adult rat
Namioka A, Namioka T, Sasaki M, Kocsis JD, Honmou O. Focal brainstem infarction in the adult rat. Lab Animal 2021, 50: 97-107. PMID: 33564191, DOI: 10.1038/s41684-021-00722-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain Stem InfarctionsDisease Models, AnimalFemaleHumansRatsRats, Sprague-DawleyStrokeConceptsBrainstem ischemiaNew therapeutic approachesIschemic lesionsFunctional recoveryTherapeutic approachesAnimal modelsFemale Sprague-Dawley ratsBrainstem ischemic lesionsLower basilar arteryArtery occlusion modelIschemic lesion volumeType of strokeReliable animal modelSprague-Dawley ratsBrainstem infarctionExtended observation periodNeurological deficitsBasilar arteryLesion volumeOcclusion modelAdult ratsIschemiaPresent symptomsSurvival rateHigher survival rate
2018
Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury
Oshigiri T, Sasaki T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Oka S, Morita T, Hirota R, Yoshimoto M, Yamashita T, Hashimoto-Torii K, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury. Journal Of Neurotrauma 2018, 36: 411-420. PMID: 29901416, PMCID: PMC6352512, DOI: 10.1089/neu.2018.5793.Peer-Reviewed Original ResearchConceptsSpinal cord injuryInfused mesenchymal stem cellsMesenchymal stem cellsCord injuryIntravenous infusionFunctional improvementAcute spinal cord injuryBlood-spinal cord barrierGene expression signaturesAxonal sproutingFunctional recoveryMotor cortexSystemic infusionVehicle infusionSpinal cordRat modelTherapeutic mechanismImproved functionInfusionTranscription-polymerase chain reaction dataPearson correlation analysisBehavioral functionsExpression signaturesGenome-wide RNA profilingRecent evidenceFunctional recovery after the systemic administration of mesenchymal stem cells in a rat model of neonatal hypoxia-ischemia.
Sakai T, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Fukumura S, Kobayashi M, Tsutsumi H, Kocsis JD, Honmou O. Functional recovery after the systemic administration of mesenchymal stem cells in a rat model of neonatal hypoxia-ischemia. Journal Of Neurosurgery Pediatrics 2018, 22: 513-522. PMID: 30074448, DOI: 10.3171/2018.5.peds1845.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDisease Models, AnimalHypoxia-Ischemia, BrainMesenchymal Stem Cell TransplantationRatsRats, Sprague-DawleyRecovery of FunctionConceptsNeonatal hypoxia-ischemiaMesenchymal stem cellsHypoxia-ischemiaRat modelHypoxic-ischemic encephalopathyStem cellsCerebral palsyFunctional recoveryFunctional outcomeSystemic administrationIntravenous administrationAnimal studiesBrain volumePotential treatmentAdministrationPalsyCellsPatientsEncephalopathySynaptogenesisPreservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction
Nagahama H, Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Namioka T, Namioka A, Oka S, Onodera R, Suzuki J, Sasaki Y, Kocsis JD, Honmou O. Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction. Brain Research 2018, 1695: 37-44. PMID: 29802840, DOI: 10.1016/j.brainres.2018.05.033.Peer-Reviewed Original ResearchConceptsInterhemispheric cortical connectionsCorpus callosumIntravenous infusionMesenchymal stem cellsDiffusion tensor imagingMotor cortexFunctional improvementCortical connectionsAdeno-associated virusRat middle cerebral artery occlusion stroke modelMiddle cerebral artery occlusion stroke modelContralateral motor cortexBlood-brain barrierMotor cortex connectivityVehicle-infused groupMRI diffusion tensor imagingPotential therapeutic mechanismNeuroanatomical tracing techniquesStem cellsCerebral infarctionInflammatory infiltrationAnatomical restorationCerebral strokeFunctional recoveryNeurotrophic factorIntravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus
Fukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGlutamate DecarboxylaseGreen Fluorescent ProteinsHippocampusInfusions, IntravenousLithiumMagnetic Resonance ImagingMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMuscarinic AgonistsNeuronsPhosphopyruvate HydratasePilocarpineRatsRats, Sprague-DawleyRats, TransgenicStatus EpilepticusTime FactorsConceptsAberrant mossy fiber sproutingMossy fiber sproutingStatus epilepticusNeuronal cell deathMesenchymal stem cellsMSC infusionIntravenous infusionRat modelCognitive functionMorris water maze testCognitive function preservationNumber of GAD67Water maze testVehicle-infused ratsMagnetic resonance imagingCell deathStem cellsSeizure frequencyFiber sproutingFunction preservationTimm stainingMaze testHippocampal neuronsImmunohistochemical stainingCognitive deterioration
2017
Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats.
Nakamura H, Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Namioka T, Namioka A, Onodera R, Suzuki J, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Elevated brain derived neurotrophic factor levels in plasma reflect in vivo functional viability of infused mesenchymal stem cells for stroke in rats. Journal Of Neurosurgical Sciences 2017, 63: 42-49. PMID: 28181779, DOI: 10.23736/s0390-5616.17.03989-3.Peer-Reviewed Original ResearchConceptsInfused mesenchymal stem cellsMiddle cerebral artery occlusionVivo functional viabilityBDNF levelsMSC infusionMesenchymal stem cellsMCAO inductionPlasma BDNFNeurotrophic factorLesion volumeMSC groupMiddle cerebral artery occlusion modelPermanent middle cerebral artery occlusionCerebral infarction rat modelBrain BDNF levelsElicit functional recoveryIntravenous MSC infusionLimb placement testNeurotrophic factor levelsPlasma BDNF levelsCerebral artery occlusionArtery occlusion modelRat stroke modelFunctional viabilityImmunosorbent assay analysesIntravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats.
Nakazaki M, Sasaki M, Kataoka-Sasaki Y, Oka S, Namioka T, Namioka A, Onodera R, Suzuki J, Sasaki Y, Nagahama H, Mikami T, Wanibuchi M, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells inhibits intracranial hemorrhage after recombinant tissue plasminogen activator therapy for transient middle cerebral artery occlusion in rats. Journal Of Neurosurgery 2017, 127: 917-926. PMID: 28059661, DOI: 10.3171/2016.8.jns16240.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionRecombinant tissue plasminogen activatorMiddle cerebral artery occlusionRegional cerebral blood flowCerebral artery occlusionMesenchymal stem cellsHemorrhagic eventsArtery occlusionEndothelial dysfunctionRtPA therapyIntracerebral hemorrhageIntravenous infusionIncidence rateNormal salineIntravenous recombinant tissue plasminogen activatorRecombinant tissue plasminogen activator therapyTissue plasminogen activator therapyInfused mesenchymal stem cellsMatrix metalloproteinase-9 levelsEarly behavioral recoveryNon-rtPA groupAcute ischemic strokeVascular endothelial dysfunctionExperimental stroke modelsMetalloproteinase-9 levels
2016
Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury
Morita T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Oka S, Oshigiri T, Takebayashi T, Yamashita T, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury. Neuroscience 2016, 335: 221-231. PMID: 27586052, DOI: 10.1016/j.neuroscience.2016.08.037.Peer-Reviewed Original ResearchConceptsSpinal cord injuryIntravenous infusionMesenchymal stem cellsCord injuryBone marrowBlood-spinal cord barrier integrityPhases of SCIChronic spinal cord injuryOpen-field locomotor functionContusive spinal cord injurySevere Contusive Spinal Cord InjuryVehicle-treated groupStem cellsAdult bone marrowBSCB leakageMSC infusionExtensive remyelinationMotor recoveryFunctional recoverySerotonergic fibersCorticospinal tractSystemic infusionFunctional improvementSpinal cordRat modelSynergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats
Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionIntravenous infusionDaily rehabilitationMesenchymal stem cellsMSC infusionFunctional outcomePermanent middle cerebral artery occlusionLimb placement testCerebral artery occlusionRat stroke modelRat MCAO modelIntraluminal vascular occlusionMagnetic resonance imagingStem cellsAdult bone marrowArtery occlusionCerebral ischemiaMCAO modelVascular occlusionFunctional improvementLesion volumeTherapy groupTherapeutic effectStroke modelGroup 2
2015
Intravenous Preload of Mesenchymal Stem Cells Rescues Erectile Function in a Rat Model of Cavernous Nerve Injury
Takayanagi A, Sasaki M, Kataoka-Sasaki Y, Kobayashi K, Matsuda Y, Oka S, Masumori N, Kocsis JD, Honmou O. Intravenous Preload of Mesenchymal Stem Cells Rescues Erectile Function in a Rat Model of Cavernous Nerve Injury. The Journal Of Sexual Medicine 2015, 12: 1713-1721. PMID: 26211660, DOI: 10.1111/jsm.12957.Peer-Reviewed Original ResearchConceptsMajor pelvic ganglionGlia cell-derived neurotrophic factorArterial pressureCN injuryErectile dysfunctionIntracavernous pressureMesenchymal stem cellsMSC groupErectile functionDMEM groupNeurotrophic factorCavernous nerve injury modelMale Sprague-Dawley ratsNerve injury modelPotential preventive effectMale SD ratsImportant neurotrophic factorSprague-Dawley ratsReal-time quantitative real-time polymerase chain reactionExpression levelsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionMRNA expression levelsPelvic gangliaPolymerase chain reactionDiffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells
Matsushita T, Lankford KL, Arroyo EJ, Sasaki M, Neyazi M, Radtke C, Kocsis JD. Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Experimental Neurology 2015, 267: 152-164. PMID: 25771801, DOI: 10.1016/j.expneurol.2015.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBlood-Brain BarrierCell- and Tissue-Based TherapyDisease Models, AnimalEndothelial CellsExploratory BehaviorGlial Fibrillary Acidic ProteinLocomotionMaleMesenchymal Stem CellsMicrovesselsPermeabilityRatsRats, Sprague-DawleyRats, TransgenicReceptor, Platelet-Derived Growth Factor betaSpinal Cord InjuriesTime FactorsVon Willebrand FactorConceptsSpinal cord injuryContusive spinal cord injuryBlood-spinal cord barrierBSCB leakageIntravenous infusionMesenchymal stem cellsVon Willebrand factorMSC infusionCord injurySpinal cordBlood-spinal cord barrier disruptionExperimental spinal cord injuryIntravenous MSC infusionSpinal cord barrierEx vivo optical imagingDissociation of pericytesBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsBSCB integrityBSCB permeabilityLocomotor recoveryPost-SCIBarrier disruptionAntigen expression
2014
Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats
Suzuki S, Kawamata J, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S. Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats. Neuroscience Letters 2014, 584: 276-281. PMID: 25449872, DOI: 10.1016/j.neulet.2014.10.039.Peer-Reviewed Original ResearchConceptsHuman bone marrow-derived mesenchymal stem cellsTherapeutic effectParkinson's diseaseCalcium binding adaptor molecule 1Mesenchymal stem cell administrationSubstantia nigra pars compactaHemi-parkinsonian rat modelParkinsonian model ratsTH-positive neuronsAdaptor molecule 1Anti-inflammatory factorsStem cell administrationNovel therapeutic optionsSham-operated ratsBone marrow-derived mesenchymal stem cellsMarrow-derived mesenchymal stem cellsGlial activationPars compactaCell administrationTherapeutic optionsDopaminergic neuronsModel ratsDopaminergic neurodegenerationNovel therapiesRat model
2013
Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain
Lankford KL, Brown RJ, Sasaki M, Kocsis JD. Olfactory ensheathing cells, but not schwann cells, proliferate and migrate extensively within moderately X‐Irradiated juvenile rat brain. Glia 2013, 62: 52-63. PMID: 24166823, DOI: 10.1002/glia.22583.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntigensCD11b AntigenCell MovementCell ProliferationCells, CulturedFemaleGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsMaleNeurogliaOlfactory MucosaOligodendrogliaProteoglycansRadiation Injuries, ExperimentalRatsRats, Sprague-DawleySchwann CellsStem Cell TransplantationConceptsJuvenile rat brainAdult spinal cordIntact adult spinal cordSchwann cellsSpinal cordRat brainAdult rat spinal cordSpinal cord lesionsRat spinal cordCord lesionsModerate radiation doseNeuronal repairPoor survivalAdult CNSUnbiased stereologyCordOECsBrainThree weeksNumber of cellsRadiation dosePermissive environmentCell migrationCellsMicroglia
2012
Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model
Suzuki J, Sasaki M, Harada K, Bando M, Kataoka Y, Onodera R, Mikami T, Wanibuchi M, Mikuni N, Kocsis JD, Honmou O. Bilateral cortical hyperactivity detected by fMRI associates with improved motor function following intravenous infusion of mesenchymal stem cells in a rat stroke model. Brain Research 2012, 1497: 15-22. PMID: 23274536, DOI: 10.1016/j.brainres.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InfarctionCerebral CortexDisease Models, AnimalExercise TestImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMagnetic Resonance ImagingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMovement DisordersOxygenRatsRats, Sprague-DawleyStatistics, NonparametricTime FactorsConceptsMSC groupMesenchymal stem cellsLesion volumeFunctional MRISensorimotor cortexMotor functionElectrical stimulationRat cerebral infarction modelGreater functional recoveryCerebral infarction modelImproved motor functionImproved functional outcomesRat stroke modelHigh-intensity signalStem cellsFunctional recoveryBilateral signalsCortical hyperactivityFunctional outcomeIntravenous infusionIntravenous transplantationFunctional deficitsSomatosensory cortexInfused groupStroke model
2009
BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord Injury
Sasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K, Honmou O, Kocsis JD. BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord Injury. Journal Of Neuroscience 2009, 29: 14932-14941. PMID: 19940189, PMCID: PMC2825276, DOI: 10.1523/jneurosci.2769-09.2009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorCells, CulturedCytoprotectionDisease Models, AnimalFemaleGene ExpressionGenetic VectorsGrowth ConesHumansMesenchymal Stem Cell TransplantationNerve RegenerationNeuronal PlasticityPyramidal TractsRatsRats, Sprague-DawleyRecovery of FunctionSpinal Cord InjuriesTransfectionTransplantation, HeterologousTreatment OutcomeConceptsSpinal cord injuryMesenchymal stem cellsCord injuryFunctional outcomeBone marrowAcute spinal cord injuryBrain-derived neurotrophic factorCorticospinal tract neuronsNumber of FGImproved functional outcomesPrimary motor cortexSpinal gray matterPotential therapeutic effectsStem cellsM1 cortexTransection lesionCorticospinal neuronsTract neuronsAxonal sproutingFunctional recoveryVentral hornNeuronal densitySerotonergic fibersLesion cavityMotor cortexA Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery
Sasaki M, Honmou O, Kocsis JD. A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery. Methods In Molecular Biology 2009, 549: 187-195. PMID: 19378204, DOI: 10.1007/978-1-60327-931-4_13.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusion modelArtery occlusion modelCerebral ischemiaIntraluminal sutureOcclusion modelRat middle cerebral artery occlusion modelInternal carotid arteryInterventional therapeutic approachesMagnetic resonance imagingUseful experimental modelNormal pathophysiologyInfarction volumeStroke therapyPermanent occlusionCarotid arteryReversible occlusionTherapeutic approachesIntravenous deliveryResonance imagingSuture insertionExperimental modelIschemiaAnimal weightPathophysiologySuture