2021
Postoperative spinal cord ischaemia: magnetic resonance imaging and clinical features
Yasuda N, Kuroda Y, Ito T, Sasaki M, Oka S, Ukai R, Nakanishi K, Mikami T, Shibata T, Harada R, Naraoka S, Kamada T, Kawaharada N. Postoperative spinal cord ischaemia: magnetic resonance imaging and clinical features. European Journal Of Cardio-Thoracic Surgery 2021, 60: 164-174. PMID: 33517384, DOI: 10.1093/ejcts/ezaa476.Peer-Reviewed Original ResearchConceptsIschemic spinal cord injurySpinal cord injuryMagnetic resonance imagingSpinal cord levelArtery territoryAortic surgeryAortic eventsCord levelCardiovascular surgeryAnterior spinal artery territoryPosterior spinal artery territoryResonance imagingThoracic spinal cord levelLumbar spinal cord levelsSpinal cord infarctionT2-weighted MRI scansSite of infarctionT2-weighted magnetic resonance imagesHigh-intensity areaCord infarctionInfarction patternArterial territoriesSerious complicationsClinical featuresCord injury
2018
Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus
Fukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGlutamate DecarboxylaseGreen Fluorescent ProteinsHippocampusInfusions, IntravenousLithiumMagnetic Resonance ImagingMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMuscarinic AgonistsNeuronsPhosphopyruvate HydratasePilocarpineRatsRats, Sprague-DawleyRats, TransgenicStatus EpilepticusTime FactorsConceptsAberrant mossy fiber sproutingMossy fiber sproutingStatus epilepticusNeuronal cell deathMesenchymal stem cellsMSC infusionIntravenous infusionRat modelCognitive functionMorris water maze testCognitive function preservationNumber of GAD67Water maze testVehicle-infused ratsMagnetic resonance imagingCell deathStem cellsSeizure frequencyFiber sproutingFunction preservationTimm stainingMaze testHippocampal neuronsImmunohistochemical stainingCognitive deterioration
2016
Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats
Sasaki Y, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Suzuki J, Tateyama D, Oka S, Namioka T, Namioka A, Onodera R, Mikami T, Wanibuchi M, Kakizawa M, Ishiai S, Kocsis JD, Honmou O. Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats. Physical Therapy 2016, 96: 1791-1798. PMID: 27174259, DOI: 10.2522/ptj.20150504.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionIntravenous infusionDaily rehabilitationMesenchymal stem cellsMSC infusionFunctional outcomePermanent middle cerebral artery occlusionLimb placement testCerebral artery occlusionRat stroke modelRat MCAO modelIntraluminal vascular occlusionMagnetic resonance imagingStem cellsAdult bone marrowArtery occlusionCerebral ischemiaMCAO modelVascular occlusionFunctional improvementLesion volumeTherapy groupTherapeutic effectStroke modelGroup 2
2011
Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells
Sasaki M, Honmou O, Radtke C, Kocsis JD. Development of a Middle Cerebral Artery Occlusion Model in the Nonhuman Primate and a Safety Study of I.V. Infusion of Human Mesenchymal Stem Cells. PLOS ONE 2011, 6: e26577. PMID: 22039510, PMCID: PMC3200343, DOI: 10.1371/journal.pone.0026577.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMagnetic resonance imagingM1 occlusionCollateral circulationSevere groupVenous bloodOcclusion modelMesenchymal stem cellsMiddle cerebral artery occlusion modelM1 branchNHP stroke modelsExtensive collateral circulationArtery occlusion modelPost-operative courseMCA territory infarctionGreater functional improvementLeft sylvian fissureNonhuman primate modelFronto-temporal craniotomyExperimental stroke researchAfrican green monkeysStem cellsHMSC infusionTerritory infarctionNeurological examination
2009
A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery
Sasaki M, Honmou O, Kocsis JD. A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery. Methods In Molecular Biology 2009, 549: 187-195. PMID: 19378204, DOI: 10.1007/978-1-60327-931-4_13.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusion modelArtery occlusion modelCerebral ischemiaIntraluminal sutureOcclusion modelRat middle cerebral artery occlusion modelInternal carotid arteryInterventional therapeutic approachesMagnetic resonance imagingUseful experimental modelNormal pathophysiologyInfarction volumeStroke therapyPermanent occlusionCarotid arteryReversible occlusionTherapeutic approachesIntravenous deliveryResonance imagingSuture insertionExperimental modelIschemiaAnimal weightPathophysiologySuture