2023
Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects
Hirota R, Sasaki M, Honmou O, Yamashita T. Mesenchymal Stem Cell Transplantation for Spinal Cord Injury: Current Status and Prospects. Spine Surgery And Related Research 2023, 7: 319-326. PMID: 37636138, PMCID: PMC10447197, DOI: 10.22603/ssrr.2022-0234.Peer-Reviewed Original ResearchSpinal cord injuryMesenchymal stem cellsCord injuryMesenchymal stem cell transplantationSevere spinal cord injuryCentral nervous system diseaseMotor function recoveryStem cell transplantationNervous system diseasesSCI modelCell transplantationFunction recoveryIntravenous infusionMSC transplantationMotor functionRat modelIntravenous administrationSystem diseasesBone marrowSCI researchTransplantationInjuryRecent updatesStem cellsCell types
2018
Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system
Hashimoto-Torii K, Sasaki M, Chang YW, Hwang H, Waxman SG, Kocsis JD, Rakic P, Torii M. Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system. IBRO Neuroscience Reports 2018, 5: 91-98. PMID: 30480161, PMCID: PMC6240805, DOI: 10.1016/j.ibror.2018.11.003.Peer-Reviewed Original ResearchPeripheral nerve injurySpinal cordNerve injuryPeripheral nerve injury resultsAltered electrophysiological propertiesNerve injury resultsSecondary damageHeat shock factor 1Neuropathic painInjury resultsInjury siteClinical abnormalitiesShock factor 1Mouse modelMemory dysfunctionElectrophysiological propertiesCordFactor 1Cellular damageFurther deteriorationInjuryReporter systemAbnormalitiesImmediate stress responseCells
2015
41 Preload of mesenchymal stem cells via intravenous infusion prevents erectile dysfunction in a rat model of cavernous nerve injury
Takayanagi A, Sasaki M, Kataoka-Sasaki Y, Kobayashi K, Matsuda Y, Oka S, Masumori N, Honmou O. 41 Preload of mesenchymal stem cells via intravenous infusion prevents erectile dysfunction in a rat model of cavernous nerve injury. European Urology Open Science 2015, 14: e41. DOI: 10.1016/s1569-9056(15)60044-6.Peer-Reviewed Original Research
2007
Demyelinating diseases and potential repair strategies
Radtke C, Spies M, Sasaki M, Vogt PM, Kocsis JD. Demyelinating diseases and potential repair strategies. International Journal Of Developmental Neuroscience 2007, 25: 149-153. PMID: 17408905, PMCID: PMC2692731, DOI: 10.1016/j.ijdevneu.2007.02.002.Peer-Reviewed Original ResearchConceptsMultiple sclerosisInjury modelSpinal cord injuryCell-based strategiesAxon lossNerve compressionNeuroprotective potentialCord injuryFunctional outcomeClinical studiesMS lesionsTherapeutic goalsVulnerable axonsCellular transplantationNeurological disordersDemyelinationRemyelinationNeuroprotectionPotential repair strategiesCell typesSclerosisTransplantationInjuryLesionsAxonsRemyelination of the injured spinal cord
Sasaki M, Li B, Lankford KL, Radtke C, Kocsis JD. Remyelination of the injured spinal cord. Progress In Brain Research 2007, 161: 419-433. PMID: 17618995, PMCID: PMC2605400, DOI: 10.1016/s0079-6123(06)61030-3.Peer-Reviewed Original ResearchConceptsSpinal cord injuryFunctional outcomeSpinal cordContusive spinal cord injuryLong white matter tractsPotential cell therapy candidatesWhite matter tractsMyelin-forming cellsCell therapy candidatesCord injuryCentral necrotic coreClinical studiesTherapy candidatesNecrotic coreTransplantation studiesExperimental modelCordOutcomesCellsDemyelinationRemyelinationInjuryNecrosisOECsAxons