2023
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus
Yang M, Lam T, Kanyo J, Kang I, Zhou Z, Clarke S, Mamula M. Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus. Autoimmunity 2023, 56: 2282945. PMID: 37994408, PMCID: PMC10897934, DOI: 10.1080/08916934.2023.2282945.Peer-Reviewed Original ResearchAutoimmunityHumansOxidative StressProtein D-Aspartate-L-Isoaspartate MethyltransferaseProtein Processing, Post-TranslationalT-LymphocytesZAP-70 Protein-Tyrosine Kinase
2017
Oxidative Modifications in Tissue Pathology and Autoimmune Disease
Yang ML, Doyle H, Clarke SG, Herold K, Mamula M. Oxidative Modifications in Tissue Pathology and Autoimmune Disease. Antioxidants And Redox Signaling 2017, 29: 1415-1431. PMID: 29088923, PMCID: PMC6166690, DOI: 10.1089/ars.2017.7382.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesDNA MethylationHumansOxidation-ReductionProtein CarbonylationProtein Processing, Post-TranslationalProteinsReactive Oxygen SpeciesConceptsPost-translational protein modificationReactive oxygen speciesProtein modificationGene expressionAberrant gene expressionInitiation of apoptosisChromosome inactivationOxidative stressDNA methylationCellular pathwaysGenetic elementsLevels of tissueMicroenvironmental influencesProtein expressionOxygen speciesOxidative modificationTissue pathogenesisPathwayExpressionTherapeutic manipulationPotential therapeutic manipulationEnvironmental influencesCellsIntracellular autoantigensSilencing
2001
Post-translational protein modifications in antigen recognition and autoimmunity
Doyle H, Mamula M. Post-translational protein modifications in antigen recognition and autoimmunity. Trends In Immunology 2001, 22: 443-449. PMID: 11473834, DOI: 10.1016/s1471-4906(01)01976-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensAutoimmunityCommunicable DiseasesEpitopesHumansImmune ToleranceProtein Processing, Post-TranslationalProteinsSignal Transduction
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
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