2025
Dissecting the role of CAR signaling architectures on T cell activation and persistence using pooled screens and single-cell sequencing
Castellanos-Rueda R, Wang K, Forster J, Driessen A, Frank J, MartÃnez M, Reddy S. Dissecting the role of CAR signaling architectures on T cell activation and persistence using pooled screens and single-cell sequencing. Science Advances 2025, 11: eadp4008. PMID: 39951542, PMCID: PMC11827634, DOI: 10.1126/sciadv.adp4008.Peer-Reviewed Original ResearchConceptsChimeric antigen receptorT-cell phenotypeT cell responsesT cell activationCAR T cell phenotypesCAR T-cell biologyModulate T cell responsesT cell persistenceCAR-T therapySingle-cell sequencingT cell functionT cell biologyCorrelated in vitroT therapyT cellsAntigen receptorClinical outcomesCD40 costimulationCancer treatmentPhenotypeSignaling domainMembrane-proximal domainCostimulationCD40Screening approach
2023
Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
Pelissier A, Stratigopoulou M, Donner N, Dimitriadis E, Bende R, Guikema J, Martinez M, van Noesel C. Convergent evolution and B-cell recirculation in germinal centers in a human lymph node. Life Science Alliance 2023, 6: e202301959. PMID: 37640448, PMCID: PMC10462906, DOI: 10.26508/lsa.202301959.Peer-Reviewed Original ResearchConceptsGerminal centersLymph nodesHuman lymph nodesGC responseHuman LNImmune responseDevelopment of autoimmune diseasesConvergent evolutionB cell clonesB cell recirculationEffective immune responseExpanded clonesLaser capture microdissectionPhylogenetic tree analysisIndividual germinal centersB cellsAutoimmune diseasesAntigen responseMouse modelModel antigenAntigenClonal diversity
2019
A Probabilistic Model of the Germinal Center Reaction
Thomas M, Klein U, Lygeros J, MartÃnez M. A Probabilistic Model of the Germinal Center Reaction. Frontiers In Immunology 2019, 10: 689. PMID: 31001283, PMCID: PMC6456718, DOI: 10.3389/fimmu.2019.00689.Peer-Reviewed Original ResearchConceptsB cell differentiationMemory B cell differentiationSpecialized compartmentsAntibody genesPlasma cell differentiationFate selectionB cellsIndividual cell propertiesCell differentiationB cell maturationMolecular eventsEfficient stochastic simulationExtracellular dynamicsQuantitative stochastic modelMemory B cell formationAntigen affinityB cell formationGillespie algorithmDifferentiationCell propertiesCell productionMemory B cells
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