2025
The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated specialty careQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioning
2024
The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis
Nicholls-Mindlin J, Hazan H, Zhou B, Li F, Ferrara M, Levine N, Riley S, Karmani S, Mathis W, Keshavan M, Srihari V. The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis. BJPsych Open 2024, 10: e216. PMID: 39628123, PMCID: PMC11698182, DOI: 10.1192/bjo.2024.813.Peer-Reviewed Original ResearchThe impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction
Hazan H, Ferrara M, Riley S, Li F, Zhou B, Kline E, Gibbs-Dean T, Karmani S, Tayfur S, Tek C, Keshavan M, Srihari V. The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction. Schizophrenia Research 2024, 264: 457-461. PMID: 38266513, PMCID: PMC10923115, DOI: 10.1016/j.schres.2024.01.022.Peer-Reviewed Original ResearchConceptsCoordinated specialty careDuration of untreated psychosisImpact of early detectionEarly detectionEarly detection campaignsSpecialty careAdjustment scoresCampaign yearDetection campaignsMediation analysisEffects of EDRegression modelsCareUntreated psychosisPositive symptomsGAFPatientsSalutary effectsRole of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis
Venkataraman S, Hazan H, Li F, Ferrara M, Harper A, Ma J, Shah J, Musket C, Levine N, Keshavan M, Srihari V. Role of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis. Psychiatric Services 2024, 75: 427-433. PMID: 38204369, DOI: 10.1176/appi.ps.20230239.Peer-Reviewed Original ResearchDuration of untreated psychosisFirst-episode psychosis servicesFirst-episode psychosisEarly psychosis detectionLow personal incomeSocioeconomic statusUntreated psychosisOutcome of first-episode psychosisLength of duration of untreated psychosisEffectiveness of early detectionSpecialty care clinicsProlonged duration of untreated psychosisReduce duration of untreated psychosisEffects of ageLow socioeconomic statusPersonal incomeIndicators of disparitiesEarly detection effortsAssociated with younger ageYears of educationSES indicatorsCare clinicsEarly detectionBlack raceHierarchical regression
2023
Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES program
2022
Granular analysis of pathways to care and durations of untreated psychosis: A marginal delay model
Mathis W, Ferrara M, Burke S, Hyun E, Li F, Zhou B, Cahill J, Kline E, Keshavan M, Srihari V. Granular analysis of pathways to care and durations of untreated psychosis: A marginal delay model. PLOS ONE 2022, 17: e0270234. PMID: 36472968, PMCID: PMC9725156, DOI: 10.1371/journal.pone.0270234.Peer-Reviewed Original ResearchUntreated psychosisAntipsychotic prescriptionsEarly detection campaignsPatient characteristics influencesEarly detection effortsPatient characteristicsClinical nodesLonger DUPFunctional declineOutpatient programPsychosis onsetSpecialized treatmentPsychosisNumber of daysDetection campaignsNetworks of careHigh functioningPrescriptionEnrollmentPTCDurationStart dateCorrigendum to: Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial
Srihari V, Ferrara M, Li F, Kline E, Gülöksüz S, Pollard J, Cahill J, Mathis W, Sykes L, Walsh B, McDermott G, Seidman L, Gueorguieva R, Woods S, Tek C, Keshavan M. Corrigendum to: Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial. Schizophrenia Bulletin Open 2022, 3: sgac020. PMID: 39144776, PMCID: PMC11206056, DOI: 10.1093/schizbullopen/sgac020.Peer-Reviewed Original Research
2020
Analysis of Early Intervention Services on Adult Judicial Outcomes
Pollard JM, Ferrara M, Lin IH, Kucukgoncu S, Wasser T, Li F, Srihari VH. Analysis of Early Intervention Services on Adult Judicial Outcomes. JAMA Psychiatry 2020, 77: 871-872. PMID: 32320010, PMCID: PMC7177643, DOI: 10.1001/jamapsychiatry.2020.0448.Peer-Reviewed Original ResearchO1.2. REDUCING THE DURATION OF UNTREATED PSYCHOSIS IN A U.S. CATCHMENT: THE MINDMAP CAMPAIGN
Srihari V, Ferrara M, Kline E, Li F, Burke S, Cahill J, Guloksuz S, Woods S, Tek C, Keshavan M. O1.2. REDUCING THE DURATION OF UNTREATED PSYCHOSIS IN A U.S. CATCHMENT: THE MINDMAP CAMPAIGN. Schizophrenia Bulletin 2020, 46: s1-s1. PMCID: PMC7233978, DOI: 10.1093/schbul/sbaa028.001.Peer-Reviewed Original Research
2019
Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study
Ferrara M, Guloksuz S, Li F, Burke S, Tek C, Friis S, Ten Velden Hegelstad W, Joa I, Johannessen JO, Melle I, Simonsen E, Srihari VH. Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study. Schizophrenia Research 2019, 210: 128-134. PMID: 31204063, DOI: 10.1016/j.schres.2019.05.035.Peer-Reviewed Original Research
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