2025
Post–Intensive Care Syndrome and Caregiver Burden
Ahn S, LaNoue M, Su H, Moale A, Scheunemann L, Kiehl A, Douglas I, Exline M, Gong M, Khan B, Owens R, Pisani M, Rock P, Jackson J, Ely E, Girard T, Boehm L. Post–Intensive Care Syndrome and Caregiver Burden. JAMA Network Open 2025, 8: e253443. PMID: 40198074, PMCID: PMC11979734, DOI: 10.1001/jamanetworkopen.2025.3443.Peer-Reviewed Original ResearchConceptsPost-intensive care syndromeCaregiver burdenIntensive care unitKatz activities of daily livingTelephone Interview for Cognitive StatusSecondary analysisActivities of daily livingPatient-caregiver dyadsZarit Burden InterviewRandomized clinical trialsIntensive care unit survivorsFunctional Activities QuestionnairePosttraumatic Stress Disorder Checklist-Civilian VersionIntensive care unit deliriumCare of patientsAcademic medical centerOptimal care of patientsChecklist-Civilian VersionBurden InterviewActivity QuestionnaireKatz ActivitiesDaily livingFollow-upICU survivorsMain OutcomesSleep and Circadian-Related Outcomes after Critical Illness
Pisani M. Sleep and Circadian-Related Outcomes after Critical Illness. Seminars In Respiratory And Critical Care Medicine 2025 PMID: 40164118, DOI: 10.1055/a-2531-1137.Peer-Reviewed Original ResearchPost-intensive care syndromeCircadian disruptionExamined symptomsConstellation of symptomsSleep complaintsInfluence long-term outcomesSurvivors of critical illnessIntensive care unitIntensive care unit environmentSleepCritical illnessQuality of lifeCritically ill patientsIll patientsIllnessPost-ICUSymptomsStudy of critically ill patientsCigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA
Korde A, Ramaswamy A, Anderson S, Jin L, Zhang J, Hu B, Velasco W, Diao L, Wang J, Pisani M, Sauler M, Boffa D, Puchalski J, Yan X, Moghaddam S, Takyar S. Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA. Communications Biology 2025, 8: 511. PMID: 40155749, PMCID: PMC11953391, DOI: 10.1038/s42003-025-07710-y.Peer-Reviewed Original Research
2024
Effect of a Three-Component Geriatrics Bundle on Incident Delirium among Critically Ill Older Adults: A Pilot Clinical Trial.
Ferrante L, Han L, Andrews B, Cohen A, Davis J, Gritsenko D, Lee S, Pisani M, Reed N, Rouse G, Truebig J. Effect of a Three-Component Geriatrics Bundle on Incident Delirium among Critically Ill Older Adults: A Pilot Clinical Trial. Annals Of The American Thoracic Society 2024, 21: 1333-1337. PMID: 38785442, PMCID: PMC11376353, DOI: 10.1513/annalsats.202311-963rl.Peer-Reviewed Original ResearchFeasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. PMID: 39822381, PMCID: PMC11737545, DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illnessLong-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024, 12: 599-607. PMID: 38701817, PMCID: PMC11296889, DOI: 10.1016/s2213-2600(24)00077-8.Peer-Reviewed Original ResearchEffects of antipsychotic treatmentCognitive impairmentAssociated with long-term cognitive impairmentTreat deliriumLong-term cognitive impairmentLong-term outcomesTreatment of deliriumCritically ill patientsAntipsychotic treatmentZiprasidone groupHaloperidol groupFollow-upQuality-of-life outcomesAssessed survivorsZiprasidoneHaloperidolAntipsychoticsCognitive outcomesTreatment group assignmentDepartment of Veterans AffairsQuality-of-lifeIll patientsPlacebo-controlledCritical illnessLong-term follow-upChaos and Confusion: Antipsychotic Use in the ICU Within the Veterans Healthcare System During the COVID Pandemic
Murphy I, Akgun K, Burk M, Jiang R, Bryan K, Morneau K, Sutherland A, Rightnour E, Rosen A, Zavala S, Franck A, Davids B, Lee J, Wong M, Providence S, Schmitt T, Exline T, Guilbeault T, Drumright K, Klenosky B, Pisani M, Witcher P. Chaos and Confusion: Antipsychotic Use in the ICU Within the Veterans Healthcare System During the COVID Pandemic. 2024, a2717-a2717. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2717.Peer-Reviewed Original ResearchHow Much Is Too Much? An Assessment of Intensive Care Unit Sedative Use Across the Veterans Healthcare System During the COVID-19 Pandemic
Murphy I, Akgun K, Burk M, Jiang R, Bryan K, Sutherland A, Morneau K, Rightnour E, Providence S, Zavala S, Rosen A, Franck A, Wong M, Davids B, Lee J, Schmitt T, Exline T, Guilbeault T, Drumright K, Klenosky B, Pisani M, Witcher P. How Much Is Too Much? An Assessment of Intensive Care Unit Sedative Use Across the Veterans Healthcare System During the COVID-19 Pandemic. 2024, a5032-a5032. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5032.Peer-Reviewed Original ResearchEffect of a Three-Component Geriatrics Bundle on Incident Delirium Among Critically Ill Older Adults
Ferrante L, Han L, Andrews B, Cohen A, Davis J, Gritsenko D, Lee S, Pisani M, Reed N, Rouse G, Truebig J. Effect of a Three-Component Geriatrics Bundle on Incident Delirium Among Critically Ill Older Adults. 2024, a2721-a2721. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2721.Peer-Reviewed Original ResearchImpact of Structured Reporting For Lung Cancer Screening Low-Dose CT Scan Incidental Findings on Physician Management
Kunitomo Y, Sather P, Killam J, Pisani M, Slade M, Tanoue L. Impact of Structured Reporting For Lung Cancer Screening Low-Dose CT Scan Incidental Findings on Physician Management. CHEST Journal 2024, 166: 896-898. PMID: 38346557, DOI: 10.1016/j.chest.2024.02.002.Peer-Reviewed Original Research
2023
Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery
Kim D, Lee H, Pawar A, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Hohmann S, Marcantonio E, Inouye S. Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery. Journal Of The American Geriatrics Society 2023, 71: 3755-3767. PMID: 37676699, PMCID: PMC10841351, DOI: 10.1111/jgs.18580.Peer-Reviewed Original ResearchConceptsUse of antipsychoticsAcademic medical centerCommunity hospitalPostoperative periodHospital typeSurgical admissionsOlder patientsMajor surgeryAtypical antipsychoticsPsychoactive drugsIntensive care unit settingRetrospective cohort studyUse of haloperidolNon-ICU settingsUse of antiepilepticsProfessional society guidelinesPostoperative deliriumPatients 65Cohort studyHospital daysHypnotic useAgonist dexmedetomidineSociety guidelinesUnit settingMedical CenterComparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAdverse clinical eventsHospital deathMajor surgeryClinical eventsPostoperative deliriumCohort studyOlder patientsAntipsychotic drugsArrhythmia eventsCardiac arrhythmia eventsHospital adverse clinical eventsModerate-dose treatmentPremier Healthcare DatabaseHospital adverse eventsNationwide cohort studyRetrospective cohort studyAtypical antipsychotic useOral antipsychotic drugsSignificant differencesHaloperidol useIschemic attackOral antipsychoticsAdverse eventsOral haloperidolSymptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report
Guttormson J, Khan B, Brodsky M, Chlan L, Curley M, GĂ©linas C, Happ M, Herridge M, Hess D, Hetland B, Hopkins R, Hosey M, Hosie A, Lodolo A, McAndrew N, Mehta S, Misak C, Pisani M, van den Boogaard M, Wang S. Symptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2023, 20: 491-498. PMID: 37000144, PMCID: PMC10112406, DOI: 10.1513/annalsats.202301-023st.Peer-Reviewed Original ResearchConceptsSymptom assessmentCritical care pharmacistsPatient-centered assessmentClinical practice developmentPractice guideline recommendationsRoutine assessmentAssessment of adult patientsMechanically ventilated patientsSymptom managementCare pharmacistsPatient experienceRespiratory therapistsPatient distressNonvocal patientsCritical careGuideline recommendationsIntensive care unit patientsMultiple symptomsSpeech-language pathologistsWorkshop participantsPractice developmentClinical practiceWorkgroup consensusUnit patientsSymptomsA Tool to Assess Competence in Critical Care Ultrasound Based on Entrustable Professional Activities
Israel H, Slade M, Gielissen K, Liu R, Pisani M, Chichra A. A Tool to Assess Competence in Critical Care Ultrasound Based on Entrustable Professional Activities. ATS Scholar 2023, 4: 61-75. PMID: 37089679, PMCID: PMC10117444, DOI: 10.34197/ats-scholar.2022-0063oc.Peer-Reviewed Original ResearchCritical care ultrasoundCritical care fellowsCare ultrasoundStudy periodAssessment toolEntrustable professional activitiesCritical Care SocietyResponse process validityAssessment of validitySingle institutionExpert consensusNominal group techniqueEntrustment scoresSufficient validity evidenceRegression analysisScoresContent validityClinical workflowProcess validityRegression modelsValidity evidenceUltrasoundHigh agreementCore Entrustable Professional ActivitiesICUExercise and nutrition in critically ill patients-What is the correct formula?
Pisani M. Exercise and nutrition in critically ill patients-What is the correct formula? Heart & Lung 2023, 58: 236-237. PMID: 36702716, DOI: 10.1016/j.hrtlng.2022.12.015.Peer-Reviewed Original Research
2016
Life-Threatening Amlodipine Overdose in an Obese Male
Israel R, Lemieux S, Chernova I, Pisani M. Life-Threatening Amlodipine Overdose in an Obese Male. CHEST Journal 2016, 150: 372a. DOI: 10.1016/j.chest.2016.08.385.Peer-Reviewed Original ResearchDexmedetomidine for hyperactive delirium: worth further study
Knauert MP, Pisani MA. Dexmedetomidine for hyperactive delirium: worth further study. Journal Of Thoracic Disease 2016, 8: e999-e1002. PMID: 27747045, PMCID: PMC5059358, DOI: 10.21037/jtd.2016.08.14.Commentaries, Editorials and LettersRisk factorsIntensive care unit patientsLength of ICUHistory of hypertensionCare unit patientsManagement of painPre-existing dementiaSeverity of illnessClinical practice guidelinesCritical care issuesHigher healthcare costsHistory of alcoholismLong-term cognitionPoor ICU outcomesCritical care medicineICU incidenceICU medicationsIntravenous haloperidolHospital stayHyperactive deliriumICU deliriumAdult patientsUnit patientsMechanical ventilationICU outcomesPerceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers
Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.Peer-Reviewed Original ResearchConceptsPoor sleepICU outcomesProviders' perceptionsIntensive care unit outcomesAvailable evidence-based guidelinesDevelopment of deliriumIntensive care unitEvidence-based guidelinesCritical care providersBetter sleep qualityMinority of providersICU surveyICU patientsIll patientsCare unitMechanical ventilationICU providersPatient outcomesRecent guidelinesPhysical therapyMost cliniciansPromotion protocolSleep qualityCare providersICUCommunity-based Participatory Research Is Needed to Address Pulmonary Health Disparities
Harris DA, Pensa MA, Redlich CA, Pisani MA, Rosenthal MS. Community-based Participatory Research Is Needed to Address Pulmonary Health Disparities. Annals Of The American Thoracic Society 2016, 13: 1231-1238. PMID: 27249657, DOI: 10.1513/annalsats.201601-054ps.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCommunity-based participatory researchHealth disparitiesPulmonary diseaseHealth equityPediatric asthma outcomesOutcome of treatmentAmerican Thoracic SocietyAdult asthmaAsthma outcomesMedical managementLung diseaseThoracic SocietyPulmonary medicineHealth behaviorsSpecific interventionsRacial disparitiesParticipatory researchCommunity healthHealth careDiseaseNational InstituteOutcomesSustainable interventionsCommunity-based approachHealthFactors Associated with Functional Recovery among Older Intensive Care Unit Survivors
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.Peer-Reviewed Original ResearchConceptsHigher body mass indexOlder ICU survivorsIntensive care unitBody mass indexFunctional recoveryICU survivorsICU admissionMass indexOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsPoor functional recoveryCritical illnessIndependent predictorsCare unitMultivariable analysisFunctional outcomePremorbid functionPotential predictorsVision impairmentAdmissionSurvivorsAnalytic sampleFunctional activityMonths
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