2025
Post–Intensive Care Syndrome and Caregiver Burden
Ahn S, LaNoue M, Su H, Moale A, Scheunemann L, Kiehl A, Douglas I, Exline M, Gong M, Khan B, Owens R, Pisani M, Rock P, Jackson J, Ely E, Girard T, Boehm L. Post–Intensive Care Syndrome and Caregiver Burden. JAMA Network Open 2025, 8: e253443. PMID: 40198074, PMCID: PMC11979734, DOI: 10.1001/jamanetworkopen.2025.3443.Peer-Reviewed Original ResearchConceptsPost-intensive care syndromeCaregiver burdenIntensive care unitKatz activities of daily livingTelephone Interview for Cognitive StatusSecondary analysisActivities of daily livingPatient-caregiver dyadsZarit Burden InterviewRandomized clinical trialsIntensive care unit survivorsFunctional Activities QuestionnairePosttraumatic Stress Disorder Checklist-Civilian VersionIntensive care unit deliriumCare of patientsAcademic medical centerOptimal care of patientsChecklist-Civilian VersionBurden InterviewActivity QuestionnaireKatz ActivitiesDaily livingFollow-upICU survivorsMain OutcomesCigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA
Korde A, Ramaswamy A, Anderson S, Jin L, Zhang J, Hu B, Velasco W, Diao L, Wang J, Pisani M, Sauler M, Boffa D, Puchalski J, Yan X, Moghaddam S, Takyar S. Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA. Communications Biology 2025, 8: 511. PMID: 40155749, PMCID: PMC11953391, DOI: 10.1038/s42003-025-07710-y.Peer-Reviewed Original Research
2023
Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery
Kim D, Lee H, Pawar A, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Hohmann S, Marcantonio E, Inouye S. Trends in use of antipsychotics and psychoactive drugs in older patients after major surgery. Journal Of The American Geriatrics Society 2023, 71: 3755-3767. PMID: 37676699, PMCID: PMC10841351, DOI: 10.1111/jgs.18580.Peer-Reviewed Original ResearchConceptsUse of antipsychoticsAcademic medical centerCommunity hospitalPostoperative periodHospital typeSurgical admissionsOlder patientsMajor surgeryAtypical antipsychoticsPsychoactive drugsIntensive care unit settingRetrospective cohort studyUse of haloperidolNon-ICU settingsUse of antiepilepticsProfessional society guidelinesPostoperative deliriumPatients 65Cohort studyHospital daysHypnotic useAgonist dexmedetomidineSociety guidelinesUnit settingMedical CenterComparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAdverse clinical eventsHospital deathMajor surgeryClinical eventsPostoperative deliriumCohort studyOlder patientsAntipsychotic drugsArrhythmia eventsCardiac arrhythmia eventsHospital adverse clinical eventsModerate-dose treatmentPremier Healthcare DatabaseHospital adverse eventsNationwide cohort studyRetrospective cohort studyAtypical antipsychotic useOral antipsychotic drugsSignificant differencesHaloperidol useIschemic attackOral antipsychoticsAdverse eventsOral haloperidolSymptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report
Guttormson J, Khan B, Brodsky M, Chlan L, Curley M, GĂ©linas C, Happ M, Herridge M, Hess D, Hetland B, Hopkins R, Hosey M, Hosie A, Lodolo A, McAndrew N, Mehta S, Misak C, Pisani M, van den Boogaard M, Wang S. Symptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2023, 20: 491-498. PMID: 37000144, PMCID: PMC10112406, DOI: 10.1513/annalsats.202301-023st.Peer-Reviewed Original ResearchConceptsSymptom assessmentCritical care pharmacistsPatient-centered assessmentClinical practice developmentPractice guideline recommendationsRoutine assessmentAssessment of adult patientsMechanically ventilated patientsSymptom managementCare pharmacistsPatient experienceRespiratory therapistsPatient distressNonvocal patientsCritical careGuideline recommendationsIntensive care unit patientsMultiple symptomsSpeech-language pathologistsWorkshop participantsPractice developmentClinical practiceWorkgroup consensusUnit patientsSymptomsExercise and nutrition in critically ill patients-What is the correct formula?
Pisani M. Exercise and nutrition in critically ill patients-What is the correct formula? Heart & Lung 2023, 58: 236-237. PMID: 36702716, DOI: 10.1016/j.hrtlng.2022.12.015.Peer-Reviewed Original Research
2016
Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.Peer-Reviewed Original ResearchConceptsHigher body mass indexOlder ICU survivorsIntensive care unitBody mass indexFunctional recoveryICU survivorsICU admissionMass indexOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsPoor functional recoveryCritical illnessIndependent predictorsCare unitMultivariable analysisFunctional outcomePremorbid functionPotential predictorsVision impairmentAdmissionSurvivorsAnalytic sampleFunctional activityMonthsCommunity-based Participatory Research Is Needed to Address Pulmonary Health Disparities
Harris DA, Pensa MA, Redlich CA, Pisani MA, Rosenthal MS. Community-based Participatory Research Is Needed to Address Pulmonary Health Disparities. Annals Of The American Thoracic Society 2016, 13: 1231-1238. PMID: 27249657, DOI: 10.1513/annalsats.201601-054ps.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCommunity-based participatory researchHealth disparitiesPulmonary diseaseHealth equityPediatric asthma outcomesOutcome of treatmentAmerican Thoracic SocietyAdult asthmaAsthma outcomesMedical managementLung diseaseThoracic SocietyPulmonary medicineHealth behaviorsSpecific interventionsRacial disparitiesParticipatory researchCommunity healthHealth careDiseaseNational InstituteOutcomesSustainable interventionsCommunity-based approachHealthPerceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers
Kamdar BB, Knauert MP, Jones SF, Parsons EC, Parthasarathy S, Pisani MA. Perceptions and Practices Regarding Sleep in the Intensive Care Unit. A Survey of 1,223 Critical Care Providers. Annals Of The American Thoracic Society 2016, 13: 1370-7. PMID: 27104770, PMCID: PMC5021080, DOI: 10.1513/annalsats.201601-087oc.Peer-Reviewed Original ResearchConceptsPoor sleepICU outcomesProviders' perceptionsIntensive care unit outcomesAvailable evidence-based guidelinesDevelopment of deliriumIntensive care unitEvidence-based guidelinesCritical care providersBetter sleep qualityMinority of providersICU surveyICU patientsIll patientsCare unitMechanical ventilationICU providersPatient outcomesRecent guidelinesPhysical therapyMost cliniciansPromotion protocolSleep qualityCare providersICUComparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales
Knauert M, Jeon S, Murphy TE, Yaggi HK, Pisani MA, Redeker NS. Comparing average levels and peak occurrence of overnight sound in the medical intensive care unit on A-weighted and C-weighted decibel scales. Journal Of Critical Care 2016, 36: 1-7. PMID: 27546739, PMCID: PMC5097003, DOI: 10.1016/j.jcrc.2016.06.005.Peer-Reviewed Original ResearchConceptsIntensive care unitMedical intensive care unitCare unitWorld Health Organization recommendationsProspective observational studyICU patient roomsIllness severityPatient factorsMechanical ventilationObservational studyPeak occurrenceICU environmentSignificant discordanceCircadian disruptionPatient roomsDecibel scaleSound levelsEquivalent sound levelPeak measuresDeliriumLevelsMeaningful factorsSleepLow-frequency soundAverage levelQuantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration
Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK. Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration. Journal Of General Internal Medicine 2016, 31: 1164-1171. PMID: 27259291, PMCID: PMC5023588, DOI: 10.1007/s11606-016-3671-9.Peer-Reviewed Original ResearchConceptsPost-hospital outcomesDelirium intensitySeverity measuresEpisode of deliriumPoor clinical outcomeDelirium durationDelirium episodesEntire hospitalizationAdult patientsClinical outcomesDelirium severityRelative riskIndependent cohortDeliriumStrong associationOutcomesHospitalizationCognitive changesDurationSeverityPredictive validityEpisodesAssociationCombined importancePatientsContinuation Rate of Atypical Antipsychotics After Discharge When Initiated in the Intensive Care Unit
Farrokh S, Castle AC, Heavner M, Pisani MA. Continuation Rate of Atypical Antipsychotics After Discharge When Initiated in the Intensive Care Unit. Journal Of Pharmacy Practice 2016, 30: 342-346. PMID: 27129913, DOI: 10.1177/0897190016645026.Peer-Reviewed Original ResearchConceptsIntensive care unitAtypical antipsychoticsHospital dischargeCare unitSafety outcomesLarge tertiary academic medical centerTertiary academic medical centerFinal study populationAcademic medical centerICU stayLack of evidenceCritical illnessMedical chartsQTc prolongationExtended therapyContinuation ratesInappropriate continuationMedical CenterStudy populationAntipsychoticsExclusion criteriaPhysician documentationPatientsProgress notesOutcomesEndobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration
Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-1876. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.Peer-Reviewed Original ResearchConceptsTransbronchial needle aspirationTransbronchial forceps biopsyForceps biopsyClinical trialsEndobronchial ultrasoundNeedle aspirationConvex probe EBUSSignificant adverse eventsDiagnosis of sarcoidosisExcellent diagnostic yieldSelect clinical scenariosSequential useTBNA samplesSecondary outcomesUnselected patientsAdverse eventsLymph nodesThoracic lymphadenopathyEBUS guidanceGranulomatous inflammationCore biopsyGranulomatous diseaseAdequate specimensNeedle biopsyDiagnostic yieldComparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease
Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of Transbronchial and Cryobiopsies in Evaluation of Diffuse Parenchymal Lung Disease. Journal Of Bronchology & Interventional Pulmonology 2016, 23: 14-21. PMID: 26705007, PMCID: PMC4864578, DOI: 10.1097/lbr.0000000000000246.Peer-Reviewed Original ResearchConceptsDiffuse parenchymal lung diseaseTransbronchial lung cryobiopsyTransbronchial lung biopsyParenchymal lung diseaseLung diseaseFlexible bronchoscopyDiagnostic yieldTertiary care academic centerVideo-assisted thoracoscopic surgeryInterstitial lung diseaseHigh diagnostic yieldTBLB specimensLung biopsyLung cryobiopsyMassive hemoptysisPrior malignancyThoracoscopic surgeryClinicopathologic featuresHypersensitivity pneumonitisModerate sedationRetrospective studyTherapeutic optionsMean ageFinal diagnosisPostprocedural outcomes
2015
The authors reply
Murphy TE, Araujo KL, Pisani MA. The authors reply. Critical Care Medicine 2015, 43: e589-e590. PMID: 26575672, PMCID: PMC4686334, DOI: 10.1097/ccm.0000000000001342.Peer-Reviewed Original ResearchAwake or Sedated: Trends in the Evaluation and Management of Agitation in the Intensive Care Unit
DeBiasi EM, AkgĂĽn KM, Pisani M. Awake or Sedated: Trends in the Evaluation and Management of Agitation in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2015, 36: 899-913. PMID: 26595050, DOI: 10.1055/s-0035-1564875.BooksConceptsICU patientsSedation practicesIll intensive care unit (ICU) patientsIntensive care unit patientsSedation assessment scaleMechanical ventilation durationCare unit patientsManagement of agitationMost ICU patientsIntensive care unitImproved clinical outcomesMultidisciplinary treatment modelLife-saving interventionsHospital lengthMinimal sedationSedative medicationsUnit patientsCare unitClinical outcomesMechanical ventilationVentilation durationPatient distressFunctional impairmentPractice guidelinesPatient discomfortAssociation of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans
Attia EF, McGinnis KA, Feemster LC, AkgĂĽn KM, Butt AA, Graber CJ, Fine MJ, Goetz MB, Rodriguez-Barradas MC, Pisani MA, Tindle HA, Brown ST, Hoo G, Rimland D, Gibert CL, Huang L, Freiberg MS, Hough CL, Crothers K. Association of COPD With Risk for Pulmonary Infections Requiring Hospitalization in HIV-Infected Veterans. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: 280-288. PMID: 26181820, PMCID: PMC4607625, DOI: 10.1097/qai.0000000000000751.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCommunity-acquired pneumoniaPneumocystis jirovecii pneumoniaIndependent risk factorIncidence rate ratiosPulmonary infectionRisk factorsAssociation of COPDBurden of COPDVeterans Aging Cohort Study Virtual CohortRisk of CAPMultivariable Poisson regression modelsBaseline comorbid conditionsDifferent pulmonary infectionsInfections Requiring HospitalizationCD4 cell countHIV viral loadChronic lung diseaseObstructive pulmonary diseaseMultivariable Poisson regressionUnadjusted incidence rateNinth Revision codesPoisson regression modelsJirovecii pneumoniaPulmonary tuberculosisThe Impact of Race on Intensity of Care Provided to Older Adults in the Medical Intensive Care Unit
Chima-Melton C, Murphy TE, Araujo KL, Pisani MA. The Impact of Race on Intensity of Care Provided to Older Adults in the Medical Intensive Care Unit. Journal Of Racial And Ethnic Health Disparities 2015, 3: 365-372. PMID: 27271078, PMCID: PMC4902115, DOI: 10.1007/s40615-015-0162-3.Peer-Reviewed Original ResearchConceptsMedical intensive care unitIntensive care unitIntensity of careTISS-28 scoresCare unitMICU interventionWhite patientsTherapeutic Intervention Scoring System-28Older adultsImpact of raceNew-onset dialysisRenal replacement therapyNon-white patientsPulmonary artery catheterizationBackgroundAfrican-AmericansICU mortalityAggressive carePrimary outcomeArtery catheterizationMechanical ventilationProspective studyReplacement therapyMore dementiaPatient preferencesChronic diseasesSedation in Critically Ill Patients
Oldham M, Pisani MA. Sedation in Critically Ill Patients. Critical Care Clinics 2015, 31: 563-587. PMID: 26118921, DOI: 10.1016/j.ccc.2015.03.010.Peer-Reviewed Original ResearchSleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit
Knauert MP, Haspel JA, Pisani MA. Sleep Loss and Circadian Rhythm Disruption in the Intensive Care Unit. Clinics In Chest Medicine 2015, 36: 419-429. PMID: 26304279, DOI: 10.1016/j.ccm.2015.05.008.BooksConceptsCritical illnessSleep disruptionAppropriate administrative supportIntensive care unit environmentIntensive care unitCircadian rhythm disruptionDelirium reductionIll patientsCare unitPharmacologic interventionsSleep disturbancesRhythm disruptionCare deliveryMultidisciplinary strategyUnit environmentSleep lossIllnessDisruptionPatientsEffective strategySleepEnvironmental factors
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