2025
Post–Intensive Care Syndrome and Caregiver Burden
Ahn S, LaNoue M, Su H, Moale A, Scheunemann L, Kiehl A, Douglas I, Exline M, Gong M, Khan B, Owens R, Pisani M, Rock P, Jackson J, Ely E, Girard T, Boehm L. Post–Intensive Care Syndrome and Caregiver Burden. JAMA Network Open 2025, 8: e253443. PMID: 40198074, PMCID: PMC11979734, DOI: 10.1001/jamanetworkopen.2025.3443.Peer-Reviewed Original ResearchConceptsPost-intensive care syndromeCaregiver burdenIntensive care unitKatz activities of daily livingTelephone Interview for Cognitive StatusSecondary analysisActivities of daily livingPatient-caregiver dyadsZarit Burden InterviewRandomized clinical trialsIntensive care unit survivorsFunctional Activities QuestionnairePosttraumatic Stress Disorder Checklist-Civilian VersionIntensive care unit deliriumCare of patientsAcademic medical centerOptimal care of patientsChecklist-Civilian VersionBurden InterviewActivity QuestionnaireKatz ActivitiesDaily livingFollow-upICU survivorsMain Outcomes
2024
Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024, 12: 599-607. PMID: 38701817, PMCID: PMC11296889, DOI: 10.1016/s2213-2600(24)00077-8.Peer-Reviewed Original ResearchEffects of antipsychotic treatmentCognitive impairmentAssociated with long-term cognitive impairmentTreat deliriumLong-term cognitive impairmentLong-term outcomesTreatment of deliriumCritically ill patientsAntipsychotic treatmentZiprasidone groupHaloperidol groupFollow-upQuality-of-life outcomesAssessed survivorsZiprasidoneHaloperidolAntipsychoticsCognitive outcomesTreatment group assignmentDepartment of Veterans AffairsQuality-of-lifeIll patientsPlacebo-controlledCritical illnessLong-term follow-up
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