2000
Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects
Winther L, Saleem R, McCance-Katz E, Rosen M, Hameedi F, Pearsall H, Jatlow P, Kosten T, Woods S. Effects of Lamotrigine on Behavioral and Cardiovascular Responses to Cocaine in Human Subjects. The American Journal Of Drug And Alcohol Abuse 2000, 26: 47-59. PMID: 10718163, DOI: 10.1081/ada-100100590.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateGlutamate release inhibitorEffects of lamotrigineCocaine-dependent volunteersMood States questionnaireLamotrigine pretreatmentAcute pretreatmentCardiovascular responsesRelaxing effectRelease inhibitorIntranasal cocaineStudy daysDrug effectsLamotriginePredetermined time intervalsCocainePlaceboHuman subjectsState QuestionnaireExperimental sessionsSubjectsMood effectsBehavioral responsesSubjective ratings
1999
The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Rosen M, Kosten T, Kreek M. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry 1999, 45: 1636-1645. PMID: 10376126, DOI: 10.1016/s0006-3223(98)00259-5.Peer-Reviewed Original ResearchConceptsWeeks of treatmentDrug effectsStrongest drug effectsOpioid antagonist naltrexoneActive naltrexoneNaltrexone treatmentNaltrexone maintenanceAntagonist naltrexoneHealthy subjectsHealthy volunteersWeek 1Week 2Cortisol levelsYohimbineWeek 5PlaceboPreclinical researchNaltrexoneAlters sensitivityEffect of pretreatmentWeeksAntagonistTreatmentStress responsivenessSubjects