2024
Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, Al‐Kindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction disease
2023
Mortality trends of aortic stenosis in high-income countries from 2000 to 2020
Hibino M, Pandey A, Hibino H, Verma R, Aune D, Yanagawa B, Takami Y, Bhatt D, Attizzani G, Pelletier M, Verma S. Mortality trends of aortic stenosis in high-income countries from 2000 to 2020. Heart 2023, 109: 1473-1478. PMID: 37208159, DOI: 10.1136/heartjnl-2023-322397.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesAge-specific mortality ratesMortality trendsCrude mortality rateHigh-income countriesJoinpoint regressionCalculate age-specific mortality ratesMortality rateWHO mortality databaseAnnual percentage changeYounger age groupsMortality DatabaseAortic stenosisPercentage changeJoinpointAge groupsMortalityPersonsAustraliaDecreasing trendYearsCountriesObservation periodStenosisWHOClinical impact of right ventricular pacing burden in patients with post-transcatheter aortic valve replacement permanent pacemaker implantation
Tsushima T, Al-Kindi S, Dallan L, Fares A, Yoon S, Wheat H, Attizzani G, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S. Clinical impact of right ventricular pacing burden in patients with post-transcatheter aortic valve replacement permanent pacemaker implantation. EP Europace 2023, 25: 1441-1450. PMID: 36794441, PMCID: PMC10105841, DOI: 10.1093/europace/euad025.Peer-Reviewed Original ResearchConceptsRight ventricular pacing burdenTranscatheter aortic valve replacementVentricular pacing burdenPermanent pacemaker implantationPermanent pacemakerHeart failurePacing burdenPPM implantationRetrospective study of consecutive patientsLikelihood of heart failureStudy of consecutive patientsLeft ventricular ejection fractionAssociated with worse outcomesVentricular ejection fractionAortic valve replacementAtrial fibrillation burdenValve implantation depthConsecutive patientsEjection fractionValve replacementPost-TAVRClinical benefitPacemaker implantationRetrospective studySingle-centreCor-Knot Use in SAVR Facilitates Coplanar Angle Adjustment During TAVR.
Hibino M, Palma Dallan L, Yoon S, Pelletier M, Ukaigwe A, Baeza C. Cor-Knot Use in SAVR Facilitates Coplanar Angle Adjustment During TAVR. Journal Of Invasive Cardiology 2023, 35: e108-e109. PMID: 36735874, DOI: 10.25270/jic/22.00156.Peer-Reviewed Original ResearchConceptsCOR-KNOTMinimally invasive cardiac surgeryPreoperative computed tomography scansInvasive cardiac surgeryAortic pressure gradientTrifecta valveCardiac surgeryAortic annulusConduction abnormalitiesParavalvular leakageRenal injuryTomography scanMm HgTAVR proceduresSurgical anatomyOperative timeTAVR valvesTAVRNext dayControl pacingFeasibility and Safety of Exclusive Noncontrast Computed Tomography for Planning of Transcatheter Aortic Valve Implantation With Self-Expandable Valves
Hibino M, Yoon S, Dallan L, Pelletier M, Rushing G, Filby S, Elgudin Y, Ukaigwe A, Baeza C, Attizzani G. Feasibility and Safety of Exclusive Noncontrast Computed Tomography for Planning of Transcatheter Aortic Valve Implantation With Self-Expandable Valves. The American Journal Of Cardiology 2023, 190: 122-124. PMID: 36623398, DOI: 10.1016/j.amjcard.2022.12.018.Peer-Reviewed Original Research
2022
Comparison of Hemodynamic Performance of Transcatheter Aortic Valve Implantation With Supra-Annular Self-Expanding Versus Balloon-Expandable Valves Assessed by Exercise Cardiovascular Magnetic Resonance
Attizzani G, Dallan L, Yoon S, Feroze R, Rajagopalan V, Baeza C, Pelletier M, Al-Kindi S, Rajagopalan S, Rashid I. Comparison of Hemodynamic Performance of Transcatheter Aortic Valve Implantation With Supra-Annular Self-Expanding Versus Balloon-Expandable Valves Assessed by Exercise Cardiovascular Magnetic Resonance. The American Journal Of Cardiology 2022, 178: 169-171. PMID: 35842277, DOI: 10.1016/j.amjcard.2022.06.015.Peer-Reviewed Original ResearchRisk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation
Tsushima T, Main A, Al-Kindi S, Dallan L, Wheat H, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S, Ohno Y, Lee K, Siqueira D, Kaneko T, Harloff M, Costa G, Barbanti M, Attizzani G. Risk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2022, 175: 80-87. PMID: 35597627, DOI: 10.1016/j.amjcard.2022.03.053.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionTranscatheter aortic valve implantationPersistent left bundle branch blockAssociated with cardiac mortalityNOP-LBBBLeft bundle branch blockLong-term outcomesBundle branch blockAortic valve implantationCardiac mortalityRisk stratificationComposite outcomeNew-onset persistent left bundle branch blockBranch blockValve implantationRetrospective study of patientsVentricular ejection fractionStudy of patientsHeart failure readmissionEjection fractionPermanent pacemakerRetrospective studyHeart failurePost-TAVIPatients
2021
Redo‐transcatheter aortic valve replacement with the supra‐annular, self‐expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry
Attizzani GF, Dallan LAP, Forrest JK, Reardon MJ, Szeto WY, Liu F, Pelletier M. Redo‐transcatheter aortic valve replacement with the supra‐annular, self‐expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry. Catheterization And Cardiovascular Interventions 2021, 99: 869-876. PMID: 34533891, DOI: 10.1002/ccd.29941.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHeart Valve ProsthesisHumansProsthesis DesignRegistriesRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter Valve Therapy RegistryTranscatheter aortic valveRedo-TAVRTVT RegistryRedo transcatheter aortic valve replacementBetter short-term outcomesTotal aortic regurgitationAortic valve replacementLow-risk patientsShort-term outcomesHospital mortalityIndex hospitalizationAortic regurgitationValve replacementDevice successEvolut RSafety profileMyocardial infarctionAortic valveEvolut PROPatientsRegistryMean gradientOutcomesEvolut
2020
Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement
Sheikh M, Deo S, Riaz H, Raza S, Altarabsheh S, Wilson B, Elgudin Y, Cmolik B, Pelletier M, Markowitz A. Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2020, 97: e425-e430. PMID: 32681697, DOI: 10.1002/ccd.29123.Peer-Reviewed Original ResearchConceptsValve replacementNational in-patient sampleLength of post-operative stayPropensity-matched cohort of patientsTrans-catheter aortic valve replacementPost-operative stayAortic valve replacementClinical co-variatesCohort of patientsAcute kidney injuryPropensity-matched cohortPost-procedural mortalityPost-procedural outcomesClinical outcomesKidney injurySecondary outcomesIn-patient samplePatientsLow-income patientsSafety-net hospitalHospitalOutcomesSafety-netIncome patientsNon-safety net hospitalsCochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Cochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Heart 2020, 106: 1043-1045. PMID: 32482670, DOI: 10.1136/heartjnl-2020-316661.Peer-Reviewed Original ResearchThe Sky Is Not Falling: Surgical Perspectives on a New Transcatheter Paradigm
Percy E, Hirji S, Yazdchi F, Pelletier M. The Sky Is Not Falling: Surgical Perspectives on a New Transcatheter Paradigm. Canadian Journal Of Cardiology 2020, 37: 22-26. PMID: 32649869, DOI: 10.1016/j.cjca.2020.03.016.Peer-Reviewed Original ResearchConceptsCardiac surgeonsTranscatheter aortic valve replacement trialsTreatment of aortic valve diseaseTranscatheter aortic valve replacementCardiac surgery communityLow surgical riskAortic valve replacementCardiac surgical communityAortic valve diseaseExpansion of transcatheter aortic valve replacementSurgical riskValve replacementHeart teamValve diseaseSurgical perspectiveReplacement trialsSurgery communitySurgical communityOperative volumeSurgeonsHeart medicineTrialsSurgicallyPatientsUtility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes
Hirji S, McGurk S, Kiehm S, Ejiofor J, Val F, Kolkailah A, Berry N, Sobieszczyk P, Pelletier M, Shah P, O’Gara P, Kaneko T. Utility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes. JAMA Cardiology 2020, 5: 156-165. PMID: 31851293, PMCID: PMC6990722, DOI: 10.1001/jamacardio.2019.4657.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementSurgical aortic valve replacement proceduresAortic valve replacementHospital performanceEvaluation of hospital performanceValve replacementHospital performance rankingsCohort study analyzed dataMeasure hospital performanceConcomitant coronary artery bypass graftingCoronary artery bypass graftingProcedure-related mortalityOpen-heart proceduresStudy analyzed dataPatient risk profileSurgical aortic valve replacement outcomesTAVR admissionsArtery bypass graftingMedicare beneficiariesMain OutcomesReplacement outcomesOutcome metricsRisk adjustmentBypass graftingTranscatheter vs surgical aortic valve replacement in patients with interstitial lung disease
Hirji S, Cote C, Lee J, Kiehm S, McGurk S, Pelletier M, Aranki S, Shekar P, Shah P, Kaneko T. Transcatheter vs surgical aortic valve replacement in patients with interstitial lung disease. Journal Of Cardiac Surgery 2020, 35: 571-579. PMID: 31981435, DOI: 10.1111/jocs.14421.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementInterstitial lung diseaseAortic valve replacementTranscatheter aortic valve replacement patientsIntensive care unitSurgical aortic valve replacement patientsInterstitial lung disease patientsShorter ventilation timeValve replacementOperative mortalityAortic stenosisVentilation timeLung diseaseRisk of postoperative pulmonary complicationsIsolated surgical aortic valve replacementDiagnosis of interstitial lung diseaseAssociated with significantly shorter hospitalRate of postoperative strokeIntensive care unit admissionPostoperative pulmonary complicationsSignificantly shorter hospitalSevere aortic stenosisPermanent pacemaker implantationSymptomatic aortic stenosis
2019
Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Cochrane Database Of Systematic Reviews 2019, 12: cd013319. PMID: 31860123, PMCID: PMC6984621, DOI: 10.1002/14651858.cd013319.pub2.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLength of hospital stayLow surgical riskAortic valve replacementTranscatheter aortic valve implantationAcute kidney injuryRisk of PPM implantationRisk of atrial fibrillationSurgical riskAortic valve stenosisRandomised controlled trialsValve replacementAortic valve implantationAtrial fibrillationCardiac deathCertainty of evidenceMyocardial infarctionPPM implantationPermanent pacemakerValve implantationAssociated with shorter lengths of hospital stayNew-onset atrial fibrillationRisk ratioLong-term follow-up dataShorter length of hospital stayInequity in Access to Transcatheter Aortic Valve Replacement: A Pan-Canadian Evaluation of Wait-Times
Wijeysundera H, Henning K, Qiu F, Adams C, Al Qoofi F, Asgar A, Austin P, Bainey K, Cohen E, Daneault B, Fremes S, Kass M, Ko D, Lambert L, Lauck S, MacFarlane K, Nadeem S, Oakes G, Paddock V, Pelletier M, Peterson M, Piazza N, Potter B, Radhakrishnan S, Rodes-Cabau J, Toleva O, Webb J, Welsh R, Wood D, Woodward G, Zimmermann R. Inequity in Access to Transcatheter Aortic Valve Replacement: A Pan-Canadian Evaluation of Wait-Times. Canadian Journal Of Cardiology 2019, 36: 844-851. PMID: 32349882, DOI: 10.1016/j.cjca.2019.10.018.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementTranscatheter aortic valve replacement procedureAortic valve replacementValve replacementHazard ratioMedian hazard ratioTranscatheter aortic valve replacement casesCox proportional hazards modelsMedian wait-timeTAVR accessProportional hazards modelWait-timeIdentical patientsHazards modelMultilevel Cox proportional hazards modelsEffect of provincesTranscatheterYear increaseAre we compromising on value versus performance: time to consider the Portico valve as a third major market player?
Hirji S, Leya G, Pelletier M. Are we compromising on value versus performance: time to consider the Portico valve as a third major market player? EuroIntervention 2019, 15: e818-e819. PMID: 31579012, DOI: 10.4244/eij-d-18-00966l.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHeart Valve ProsthesisHumansTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsMarket playersComparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States
Shah R, Hirji S, Jolissaint J, Lander H, Shah P, Pelletier M, Sobieszczyk P, Berry N, Shook D, Nyman C, Bhatt D, Body S, Kaneko T. Comparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States. The American Journal Of Cardiology 2019, 123: 1983-1991. PMID: 30952379, DOI: 10.1016/j.amjcard.2019.03.008.Peer-Reviewed Original ResearchConceptsRehabilitation facilitySex-based differencesRehabilitation service utilizationCo-morbiditiesTranscatheter aortic valve implantationFemale sexElixhauser co-morbiditiesHospital costsDischarged to homeBody mass indexMultivariate logistic regressionNational Inpatient Sample databaseHome-discharged patientsService utilizationChronic conditionsAortic valve implantationInpatient Sample databaseHigher hospital costsIn-hospital mortalityInpatient admissionsDischarged patientsRehabilitationMass indexLogistic regressionPatient outcomes
2018
Transcatheter Aortic Valve Replacement for Bioprosthetic Aortic Stenosis in Pregnancy
Berry N, Sawlani N, Economy K, Shook D, Nyman C, Singh M, Pelletier M, Sobieszczyk P, Kaneko T, Shah P. Transcatheter Aortic Valve Replacement for Bioprosthetic Aortic Stenosis in Pregnancy. JACC Cardiovascular Interventions 2018, 11: e161-e162. PMID: 30286865, DOI: 10.1016/j.jcin.2018.07.046.Peer-Reviewed Original ResearchMechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Aged 50 Years and Younger
Hirji S, Kolkailah A, Ramirez-Del Val F, Lee J, McGurk S, Pelletier M, Singh S, Mallidi H, Aranki S, Shekar P, Kaneko T. Mechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Aged 50 Years and Younger. The Annals Of Thoracic Surgery 2018, 106: 1113-1120. PMID: 29966596, DOI: 10.1016/j.athoracsur.2018.05.073.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAortic Valve StenosisBioprosthesisCohort StudiesDatabases, FactualFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansKaplan-Meier EstimateMaleMiddle AgedPostoperative ComplicationsPostoperative HemorrhagePrognosisPropensity ScoreProportional Hazards ModelsProsthesis DesignReoperationRetrospective StudiesRisk AssessmentSurvival AnalysisConceptsMechanical aortic valve replacementBioprosthetic AVRAortic valve replacementLong-term survivalOperative mortalityValve replacementRedo-AVRConcomitant coronary artery bypass graftingLong-term survival differenceEnd pointsIncreased risk of reoperationBioprosthetic aortic valve replacementCoronary artery bypass graftingMitral valve proceduresMedian observation timeSecondary end pointsMechanical aortic valve replacement patientsPrimary end pointRisk of reoperationArtery bypass graftingStudy evaluated outcomesValve proceduresBleeding incidenceYounger patientsSurvival differencesNovel fast-track recovery protocol for alternative access transcatheter aortic valve replacement: application to non-femoral approaches
Kolkailah A, Hirji S, Ejiofor J, Del Val F, Lee J, Norman A, McGurk S, Mahmood S, Shook D, Vlassakov K, Nyman C, Shah P, Pelletier M, Kaneko T. Novel fast-track recovery protocol for alternative access transcatheter aortic valve replacement: application to non-femoral approaches. Interdisciplinary CardioVascular And Thoracic Surgery 2018, 26: 938-943. PMID: 29365108, DOI: 10.1093/icvts/ivx409.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementPre-fast-trackAortic valve replacementAlternative access transcatheter aortic valve replacementValve replacementIntensive care unitFT protocolCare unitShorter intensive care unitMultidisciplinary heart team approachIntensive care unit timeFast-track (FTFast-track recovery protocolTranscatheter aortic valve replacement utilizationHeart team approachEnhance patient recoveryComparison of outcomesIncreased procedural complicationsFT patientsProcedural complicationsTranscatheterPatientsTransfemoral approachIliofemoral vesselsPatient recovery
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