2024
Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, Al‐Kindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction disease
2020
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Asher SR, Malzberg GW, Ong CS, Malapero RJ, Wang H, Shekar P, Kaneko T, Pelletier MP, Mallidi H, Heydarpour M, Shook DC, Shernan SK, Fox JA, Muehlschlegel JD, Xu X, Nguyen TB, Sundt TM, Body SC. Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality. Interdisciplinary CardioVascular And Thoracic Surgery 2020, 32: 9-19. PMID: 33313764, PMCID: PMC8600023, DOI: 10.1093/icvts/ivaa230.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationAortic valve replacementModerate mitral regurgitationMitral regurgitationMR severityPostoperative mortalityPreoperative transthoracicValve replacementEchocardiographic assessmentLong-term postoperative mortalityAortic valve replacement surgerySeverity of MRCoronary artery bypassLong-term mortalityValve replacement surgeryInduction of anesthesiaIschemic heart diseaseAortic valve diseaseProportional hazards regressionMitral valve repairPrediction of mortalityFunctional mitral regurgitation severityMitral regurgitation severityIntraoperative reassessmentArtery bypassAcute kidney injury in renal transplant recipients undergoing cardiac surgery
Hundemer G, Srivastava A, Jacob K, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel K, Hirji S, Pelletier M, Safa K, Kulvichit W, Kellum J, Riella L, Leaf D. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2020, 36: 185-196. PMID: 32892219, PMCID: PMC7771983, DOI: 10.1093/ndt/gfaa063.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsAcute kidney injuryNon-RTRsCardiac surgeryCalcineurin inhibitorsRisk factorsTransplant recipientsKidney injuryType of cardiac surgeryKidney diseaseRates of acute kidney injuryRisk of acute kidney injuryDeceased donorsGlobal Outcomes criteriaLiving donorsRetrospective cohort studyAssociated with higher ratesChronic kidney diseaseTrough levelsClinical characteristicsAcademic medical centerCohort studySurgeryHigh riskMedical CenterVariability in opioid prescribing practices among cardiac surgeons and trainees
Percy E, Hirji S, Cote C, Laurin C, Atkinson L, Kiehm S, Malarczyk A, Harloff M, Bozso S, Buyting R, Hassanabad A, Guo M, Jaffer I, Lodewyks C, Tam D, Tremblay P, Légaré J, Cook R, Kaneko T, Pelletier M. Variability in opioid prescribing practices among cardiac surgeons and trainees. Journal Of Cardiac Surgery 2020, 35: 2657-2662. PMID: 32720337, DOI: 10.1111/jocs.14885.Peer-Reviewed Original ResearchConceptsDischarge opioid prescriptionsOpioid prescriptionsCardiac surgeonsCardiac surgeryCanadian Society of Cardiac SurgeonsOpioid epidemicMedian total doseMorphine milligram equivalentsOpioid prescribing practicesAssociated with opioid use disorderDose of medicationOpioid use disorderMilligram equivalentsPrescribed opioidsOpioid medicationsTotal doseOpioidPrescription practicesPrescribing habitsUse disorderInterquartile rangeLack of formal educationPrescribing practicesSurgerySurgeonsSafety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement
Sheikh M, Deo S, Riaz H, Raza S, Altarabsheh S, Wilson B, Elgudin Y, Cmolik B, Pelletier M, Markowitz A. Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2020, 97: e425-e430. PMID: 32681697, DOI: 10.1002/ccd.29123.Peer-Reviewed Original ResearchConceptsValve replacementNational in-patient sampleLength of post-operative stayPropensity-matched cohort of patientsTrans-catheter aortic valve replacementPost-operative stayAortic valve replacementClinical co-variatesCohort of patientsAcute kidney injuryPropensity-matched cohortPost-procedural mortalityPost-procedural outcomesClinical outcomesKidney injurySecondary outcomesIn-patient samplePatientsLow-income patientsSafety-net hospitalHospitalOutcomesSafety-netIncome patientsNon-safety net hospitalsSex-based differences in mitral valve Re-operation after mitral valve repair: Truth or myth?
Hirji S, Guetter C, Trager L, Yazdchi F, Landino S, Lee J, Anastasopulos A, Percy E, McGurk S, Pelletier M, Aranki S, Shekar P, Kaneko T. Sex-based differences in mitral valve Re-operation after mitral valve repair: Truth or myth? The American Journal Of Surgery 2020, 220: 1344-1350. PMID: 32788080, DOI: 10.1016/j.amjsurg.2020.06.069.Peer-Reviewed Original ResearchConceptsRe-operation riskRe-operationMV repairRheumatic diseasesFemale sexMitral valve re-operationMV repair durabilityMedian follow-upMitral valve repairAssociated with rheumatic diseasesSTS risk scoreOperative mortalityValve repairPreoperative profilesAdult patientsFollow-upDisease progressionSex-based differencesRepair durabilityRepair failureWomenRepairRiskLongitudinal analysisSexThe impact of hospital size on national trends and outcomes in isolated open proximal aortic surgery
Hirji S, Shah R, Aranki S, McGurk S, Singh S, Mallidi H, Pelletier M, Shekar P, Kaneko T. The impact of hospital size on national trends and outcomes in isolated open proximal aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 1269-1278.e9. PMID: 32713639, DOI: 10.1016/j.jtcvs.2020.03.180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAortic AneurysmAortic DiseasesAortic DissectionAortic RuptureBenchmarkingBlood Vessel Prosthesis ImplantationDatabases, FactualFemaleHealth Facility SizeHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHumansLength of StayMaleMiddle AgedPostoperative ComplicationsThoracic Surgical ProceduresUnited StatesConceptsProximal aortic surgeryAortic surgeryImpact of hospital sizeHospital sizeIn-hospital cardiac complicationsLarge hospitalsProximal aortic operationsRe-do proceduresHospital costsPatients aged >Propensity-score matching analysisOverall in-hospital mortalityIn-hospital mortalityIn-hospital outcomesShorter length of stayLower hospital costsPropensity-score matchingIn-hospital mortality trendsBenchmark hospital performanceLength of stayNational Inpatient SampleConcomitant valvularAortic operationsOperative mortalityCardiac complicationsCochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Cochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Heart 2020, 106: 1043-1045. PMID: 32482670, DOI: 10.1136/heartjnl-2020-316661.Peer-Reviewed Original ResearchQuantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation
Hirji SA, Zogg CK, Vaduganathan M, Kiehm S, Percy ED, Yazdchi F, Pelletier M, Shah PB, Bhatt DL, O'Gara P, Kaneko T. Quantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 128: 113-119. PMID: 32650903, DOI: 10.1016/j.amjcard.2020.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCenters for Medicare and Medicaid Services, U.S.ComorbidityContinuity of Patient CareCoronary AngiographyDiabetes MellitusFemaleHospital CostsHospital MortalityHospitalsHumansHypertensionLength of StayLung DiseasesMaleMultivariate AnalysisPacemaker, ArtificialPatient ReadmissionPericardiocentesisPostoperative ComplicationsProsthesis ImplantationStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsNonindex hospitalNonindex readmissionsCare fragmentationTranscatheter aortic valve implantation outcomesTranscatheter aortic valve implantationHigher co-morbidity burdenNational Readmission DatabaseAortic valve implantationCo-morbidity burdenTotal hospital costsMajor cardiac proceduresUS adult patientsFuture health policyValue of careIndex readmissionTAVI patientsCause mortalityIndex hospitalNoncardiac causesAdult patientsPatient characteristicsReadmission ratesValve implantationReadmission lengthCardiac proceduresNational Outcomes of Surgical Embolectomy for Acute Pulmonary Embolism
Percy E, Shah R, Hirji S, Tartarini R, Yazdchi F, Harloff M, Kaneko T, Pelletier M. National Outcomes of Surgical Embolectomy for Acute Pulmonary Embolism. The Annals Of Thoracic Surgery 2020, 110: 441-447. PMID: 32199827, DOI: 10.1016/j.athoracsur.2020.02.024.Peer-Reviewed Original ResearchConceptsAcute pulmonary embolismCatheter-directed therapySurgical embolectomyPulmonary embolismSystemic thrombolysisContemporary outcomes of patientsTreated with systemic thrombolysisAssociated with increased odds of mortalityHigher in-hospital mortalityOutcomes of patientsIn-hospital mortalityAssociated with increased oddsOdds of mortalityReal-world studyHigh-risk conditionsNational Inpatient SampleSurgical groupIntracranial hemorrhageSaddle embolusBlood transfusionMultidisciplinary treatmentEmbolectomy patientsAtrial fibrillationSurgical patientsContemporary outcomesUtility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes
Hirji S, McGurk S, Kiehm S, Ejiofor J, Val F, Kolkailah A, Berry N, Sobieszczyk P, Pelletier M, Shah P, O’Gara P, Kaneko T. Utility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes. JAMA Cardiology 2020, 5: 156-165. PMID: 31851293, PMCID: PMC6990722, DOI: 10.1001/jamacardio.2019.4657.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementSurgical aortic valve replacement proceduresAortic valve replacementHospital performanceEvaluation of hospital performanceValve replacementHospital performance rankingsCohort study analyzed dataMeasure hospital performanceConcomitant coronary artery bypass graftingCoronary artery bypass graftingProcedure-related mortalityOpen-heart proceduresStudy analyzed dataPatient risk profileSurgical aortic valve replacement outcomesTAVR admissionsArtery bypass graftingMedicare beneficiariesMain OutcomesReplacement outcomesOutcome metricsRisk adjustmentBypass graftingRelationship Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes
Hirji S, McCarthy E, Kim D, McGurk S, Ejiofor J, Val F, Kolkailah A, Rosner B, Shook D, Nyman C, Berry N, Sobieszczyk P, Pelletier M, Shah P, O’Gara P, Kaneko T. Relationship Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes. JACC Cardiovascular Interventions 2020, 13: 335-343. PMID: 32029250, PMCID: PMC8858441, DOI: 10.1016/j.jcin.2019.09.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveClinical CompetenceDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHospitals, High-VolumeHospitals, Low-VolumeHumansMaleMedicareOutcome and Process Assessment, Health CareQuality Indicators, Health CareRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementSurgical aortic valve replacementTranscatheter aortic valve replacement outcomesAortic valve replacementValve replacementConcomitant coronary artery bypass graft surgeryGroup 2Aortic valve replacement volumesGroup 1Group 3Group 4Surgical aortic valve replacement volumeCoronary artery bypass graft surgeryTranscatheter aortic valve replacement procedureArtery bypass graft surgeryAortic valve replacement proceduresYear post-procedureOpen-heart proceduresRisk-adjusted odds ratioMultivariate Cox regressionHeart valve proceduresLow-volume centersValve replacement proceduresTAVR admissionsBypass graft surgeryOutcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty
Hirji S, Yazdchi F, Kiehm S, Landino S, McGurk S, Muehlschlegel J, Singh S, Mallidi H, Pelletier M, Aranki S, Shekar P, Kaneko T. Outcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty. The Annals Of Thoracic Surgery 2020, 110: 821-828. PMID: 32001230, DOI: 10.1016/j.athoracsur.2019.12.023.Peer-Reviewed Original ResearchConceptsTricuspid valve repairEvent-free survivalTricuspid valve reoperationValve repairTR recurrenceValve reoperationTricuspid regurgitationConcomitant aortic valveCoronary artery bypass grafting proceduresFunctional tricuspid regurgitationTricuspid valve insufficiencyTricuspid valve replacementDevice placement procedureConventional surgical techniquesIn-hospital outcomesBypass grafting proceduresBicuspidization techniqueAortic proceduresRing annuloplastyMidterm outcomesValve insufficiencyValve replacementEchocardiographic profileHeart transplantationMitral valveTranscatheter vs surgical aortic valve replacement in patients with interstitial lung disease
Hirji S, Cote C, Lee J, Kiehm S, McGurk S, Pelletier M, Aranki S, Shekar P, Shah P, Kaneko T. Transcatheter vs surgical aortic valve replacement in patients with interstitial lung disease. Journal Of Cardiac Surgery 2020, 35: 571-579. PMID: 31981435, DOI: 10.1111/jocs.14421.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementInterstitial lung diseaseAortic valve replacementTranscatheter aortic valve replacement patientsIntensive care unitSurgical aortic valve replacement patientsInterstitial lung disease patientsShorter ventilation timeValve replacementOperative mortalityAortic stenosisVentilation timeLung diseaseRisk of postoperative pulmonary complicationsIsolated surgical aortic valve replacementDiagnosis of interstitial lung diseaseAssociated with significantly shorter hospitalRate of postoperative strokeIntensive care unit admissionPostoperative pulmonary complicationsSignificantly shorter hospitalSevere aortic stenosisPermanent pacemaker implantationSymptomatic aortic stenosisThirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery
Hirji SA, Percy ED, Zogg CK, Vaduganathan M, Kiehm S, Pelletier M, Kaneko T. Thirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery. The Annals Of Thoracic Surgery 2020, 110: 484-491. PMID: 31972128, PMCID: PMC7382395, DOI: 10.1016/j.athoracsur.2019.11.042.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementNonindex readmissionsCardiac surgeryNonindex hospitalNonindex hospital readmissionsCoronary artery bypassNational Readmission DatabaseAortic valve replacementCardiac surgery patientsMajor cardiac surgeryPatient risk profileHigh-volume centersUS adult patientsRegionalization of careFragmentation of careComorbidity burdenHospital mortalityIndex readmissionArtery bypassInitial hospitalizationAdult patientsSurgery patientsValve replacementHospital readmissionIndependent predictorsLong-Term Outcomes of Right Minithoracotomy Versus Hemisternotomy for Mitral Valve Repair
Percy E, Hirji S, Yazdchi F, McGurk S, Kiehm S, Cook R, Kaneko T, Shekar P, Pelletier M. Long-Term Outcomes of Right Minithoracotomy Versus Hemisternotomy for Mitral Valve Repair. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2020, 15: 74-80. PMID: 31957524, DOI: 10.1177/1556984519891966.Peer-Reviewed Original ResearchConceptsMitral valve repairMinimally invasive mitral valve repairRight minithoracotomyValve repairLong-term survivalRT groupMitral reoperationMitral repairHS groupIsolated mitral repairCross-clamp timeFollow-up timeShort-term outcomesCox proportional hazards modelsLong-term outcomesRisk-adjusted survivalProportional hazards modelLower hemisternotomyOperative mortalityPatient yearsPostoperative complicationsLonger bypassHemisternotomyExcellent survivalMean age
2019
Myocardial preservation methods in isolated minimal invasive mitral valve surgery: Society of Thoracic Surgeons (STS) database outcomes
Loberman D, Pelletier M, Yazdchi F, Aranki S, Preisler Y, Mohr R, Ziv‐Baran T. Myocardial preservation methods in isolated minimal invasive mitral valve surgery: Society of Thoracic Surgeons (STS) database outcomes. Journal Of Cardiac Surgery 2019, 35: 163-173. PMID: 31733079, DOI: 10.1111/jocs.14351.Peer-Reviewed Original ResearchConceptsMinimally invasive mitral valve surgerySociety of Thoracic SurgeonsMitral valve surgeryInvasive mitral valve surgeryAssociated with increased riskValve surgeryEjection fractionThoracic surgeonsCrystalloid solutionRetrospective analysis of patientsTechniques of myocardial preservationSTS databaseMyocardial preservation methodsLength of ICU stayPostoperative ejection fractionAnalysis of patientsShort-term outcomesAssociated with mortalityPleural effusionICU stayRetrospective analysisTerm outcomesCPK-MBCardioplegia techniqueMultivariate analysisInequity in Access to Transcatheter Aortic Valve Replacement: A Pan-Canadian Evaluation of Wait-Times
Wijeysundera H, Henning K, Qiu F, Adams C, Al Qoofi F, Asgar A, Austin P, Bainey K, Cohen E, Daneault B, Fremes S, Kass M, Ko D, Lambert L, Lauck S, MacFarlane K, Nadeem S, Oakes G, Paddock V, Pelletier M, Peterson M, Piazza N, Potter B, Radhakrishnan S, Rodes-Cabau J, Toleva O, Webb J, Welsh R, Wood D, Woodward G, Zimmermann R. Inequity in Access to Transcatheter Aortic Valve Replacement: A Pan-Canadian Evaluation of Wait-Times. Canadian Journal Of Cardiology 2019, 36: 844-851. PMID: 32349882, DOI: 10.1016/j.cjca.2019.10.018.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementTranscatheter aortic valve replacement procedureAortic valve replacementValve replacementHazard ratioMedian hazard ratioTranscatheter aortic valve replacement casesCox proportional hazards modelsMedian wait-timeTAVR accessProportional hazards modelWait-timeIdentical patientsHazards modelMultilevel Cox proportional hazards modelsEffect of provincesTranscatheterYear increaseCardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries
Shah R, Hirji S, Percy E, Landino S, Yazdchi F, Bellavia A, Pelletier M, Shekar P, Kaneko T. Cardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries. The Annals Of Thoracic Surgery 2019, 109: 1194-1201. PMID: 31479643, DOI: 10.1016/j.athoracsur.2019.07.041.Peer-Reviewed Original ResearchConceptsOpioid use disorderCardiac surgeryIncreased risk of postoperative morbidityImpact of opioid use disorderRisk of postoperative morbidityOpioid epidemicAssociated with prolonged hospitalizationRisk factorsUse disorderOpioid use disorder statusCoronary artery bypass graftingNon-opioid usersPreoperative risk factorsCardiac surgery patientsPatient's preoperative risk factorsAcute kidney injuryArtery bypass graftingCardiac surgery outcomesIn-hospital mortalityCurrent opioid epidemicLonger hospital lengthImprove overall outcomesHigher hospital costsNational Inpatient SampleValve repairDebunking the July Effect in Cardiac Surgery: A National Analysis of More Than 470,000 Procedures
Shah RM, Hirji SA, Kiehm S, Goel S, Yazdchi F, Bellavia A, Zogg CK, Pelletier MP, Shekar P, Kaneko T. Debunking the July Effect in Cardiac Surgery: A National Analysis of More Than 470,000 Procedures. The Annals Of Thoracic Surgery 2019, 108: 929-934. PMID: 31353035, DOI: 10.1016/j.athoracsur.2019.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedCardiac Surgical ProceduresClinical CompetenceCohort StudiesDatabases, FactualEducation, Medical, GraduateFemaleHospital MortalityHospitals, TeachingHumansInpatientsInternship and ResidencyMaleMedical Staff, HospitalMiddle AgedPostoperative ComplicationsQuality of Health CareRisk AdjustmentSeasonsUnited StatesConceptsAortic valve replacementCardiac surgeryJuly effectHospital mortalityPatient outcomesTeaching hospitalMajor cardiac surgery proceduresSurgical aortic valve replacementCoronary artery bypassCardiac surgery proceduresNational Inpatient SampleRisk-adjusted mortalityMitral valve repairCardiac surgery outcomesHospital complicationsArtery bypassMV surgeryNoncardiac surgeryValve replacementAdjusted mortalityValve repairSurgery outcomesInpatient SampleWorse outcomesHospital support systems
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