2024
The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
Shah A, Ding Y, Walji D, Rabinovich G, Pelletier M, El-Diasty M. The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review. Biomarkers 2024, 29: 485-493. PMID: 39422445, DOI: 10.1080/1354750x.2024.2415073.Peer-Reviewed Original ResearchConceptsAssociated with acute kidney injuryPostoperative atrial fibrillationGal-3 levelsLeft ventricular reverse remodelingCardiac surgeryAdverse outcomesGal-3Clinical risk prediction scorePreoperative plasma levelsVentricular reverse remodelingEuroSCORE II modelPlasma Gal-3 levelsPostoperative adverse outcomesAcute kidney injuryGalectin-3Group of patientsPredicting adverse outcomesRisk prediction scorePostoperative morbidityReverse remodelingPostoperative mortalityElectronic database searchPrognostic utilityAdult patientsKidney injuryElevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, Al‐Kindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction diseasePericardial fluid troponin in cardiac surgery
Fatehi Hassanabad A, El-Sherbini A, Cherif I, Ahmad B, Gonzalez A, Pelletier M, Fedak P, El-Diasty M. Pericardial fluid troponin in cardiac surgery. Clinica Chimica Acta 2024, 559: 119722. PMID: 38734224, DOI: 10.1016/j.cca.2024.119722.Peer-Reviewed Original ResearchConceptsCardiac surgeryPericardial fluidTroponin levelsLevels of cardiac troponinPF levelsCardiac troponin levelsTroponin changesGoogle Scholar databasesTroponin concentrationsCardiac troponinProcedure typeClinical significancePrimary outcomeSurgerySecondary outcomesBiologically active factorsBlinded reviewersPreferred Reporting ItemsFull-text reviewTroponinInclusion criteriaPatientsPathological changesScholar databasesSystematic review
2023
Temporal trends in mortality of aortic dissection and rupture in the UK, Japan, the USA and Canada
Hibino M, Verma S, Jarret C, Shimamura J, Verma R, Hibino H, Baeza C, Aune D, Yanagawa B, Usui A, Nienaber C, Pelletier M. Temporal trends in mortality of aortic dissection and rupture in the UK, Japan, the USA and Canada. Heart 2023, 110: 331-336. PMID: 37648437, DOI: 10.1136/heartjnl-2023-323042.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesAge-standardised mortalityJoinpoint regressionAortic dissectionWHO mortality databaseCompare mortality trendsAnnual percentage changeMortality rateStudy periodAortic ruptureMortality trendsMortality DatabaseMortality of aortic dissectionAortic aneurysm rupturePercentage changeJoinpointTemporal trendsAortic emergenciesLower mortalityClinical outcomesAneurysm ruptureMortalityDissectionCanadaUKMortality trends of aortic stenosis in high-income countries from 2000 to 2020
Hibino M, Pandey A, Hibino H, Verma R, Aune D, Yanagawa B, Takami Y, Bhatt D, Attizzani G, Pelletier M, Verma S. Mortality trends of aortic stenosis in high-income countries from 2000 to 2020. Heart 2023, 109: 1473-1478. PMID: 37208159, DOI: 10.1136/heartjnl-2023-322397.Peer-Reviewed Original ResearchConceptsAge-standardised mortality ratesAge-specific mortality ratesMortality trendsCrude mortality rateHigh-income countriesJoinpoint regressionCalculate age-specific mortality ratesMortality rateWHO mortality databaseAnnual percentage changeYounger age groupsMortality DatabaseAortic stenosisPercentage changeJoinpointAge groupsMortalityPersonsAustraliaDecreasing trendYearsCountriesObservation periodStenosisWHOClinical impact of right ventricular pacing burden in patients with post-transcatheter aortic valve replacement permanent pacemaker implantation
Tsushima T, Al-Kindi S, Dallan L, Fares A, Yoon S, Wheat H, Attizzani G, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S. Clinical impact of right ventricular pacing burden in patients with post-transcatheter aortic valve replacement permanent pacemaker implantation. EP Europace 2023, 25: 1441-1450. PMID: 36794441, PMCID: PMC10105841, DOI: 10.1093/europace/euad025.Peer-Reviewed Original ResearchConceptsRight ventricular pacing burdenTranscatheter aortic valve replacementVentricular pacing burdenPermanent pacemaker implantationPermanent pacemakerHeart failurePacing burdenPPM implantationRetrospective study of consecutive patientsLikelihood of heart failureStudy of consecutive patientsLeft ventricular ejection fractionAssociated with worse outcomesVentricular ejection fractionAortic valve replacementAtrial fibrillation burdenValve implantation depthConsecutive patientsEjection fractionValve replacementPost-TAVRClinical benefitPacemaker implantationRetrospective studySingle-centreCor-Knot Use in SAVR Facilitates Coplanar Angle Adjustment During TAVR.
Hibino M, Palma Dallan L, Yoon S, Pelletier M, Ukaigwe A, Baeza C. Cor-Knot Use in SAVR Facilitates Coplanar Angle Adjustment During TAVR. Journal Of Invasive Cardiology 2023, 35: e108-e109. PMID: 36735874, DOI: 10.25270/jic/22.00156.Peer-Reviewed Original ResearchConceptsCOR-KNOTMinimally invasive cardiac surgeryPreoperative computed tomography scansInvasive cardiac surgeryAortic pressure gradientTrifecta valveCardiac surgeryAortic annulusConduction abnormalitiesParavalvular leakageRenal injuryTomography scanMm HgTAVR proceduresSurgical anatomyOperative timeTAVR valvesTAVRNext dayControl pacingFeasibility and Safety of Exclusive Noncontrast Computed Tomography for Planning of Transcatheter Aortic Valve Implantation With Self-Expandable Valves
Hibino M, Yoon S, Dallan L, Pelletier M, Rushing G, Filby S, Elgudin Y, Ukaigwe A, Baeza C, Attizzani G. Feasibility and Safety of Exclusive Noncontrast Computed Tomography for Planning of Transcatheter Aortic Valve Implantation With Self-Expandable Valves. The American Journal Of Cardiology 2023, 190: 122-124. PMID: 36623398, DOI: 10.1016/j.amjcard.2022.12.018.Peer-Reviewed Original Research
2022
Comparison of Hemodynamic Performance of Transcatheter Aortic Valve Implantation With Supra-Annular Self-Expanding Versus Balloon-Expandable Valves Assessed by Exercise Cardiovascular Magnetic Resonance
Attizzani G, Dallan L, Yoon S, Feroze R, Rajagopalan V, Baeza C, Pelletier M, Al-Kindi S, Rajagopalan S, Rashid I. Comparison of Hemodynamic Performance of Transcatheter Aortic Valve Implantation With Supra-Annular Self-Expanding Versus Balloon-Expandable Valves Assessed by Exercise Cardiovascular Magnetic Resonance. The American Journal Of Cardiology 2022, 178: 169-171. PMID: 35842277, DOI: 10.1016/j.amjcard.2022.06.015.Peer-Reviewed Original ResearchPercutaneous mechanical thrombectomy and extracorporeal membranous oxygenation: A case series
Mously H, Hajjari J, Chami T, Hammad T, Schilz R, Carman T, Elgudin Y, Abu‐Omar Y, Pelletier M, Shishehbor M, Li J. Percutaneous mechanical thrombectomy and extracorporeal membranous oxygenation: A case series. Catheterization And Cardiovascular Interventions 2022, 100: 274-278. PMID: 35686535, DOI: 10.1002/ccd.30295.Peer-Reviewed Original ResearchConceptsPulmonary Embolism Response TeamExtracorporeal membrane oxygenationPulmonary embolismFollow-up periodCardiac arrestPulmonary embolism response team activationHigh-risk pulmonary embolismRetrospective chart review of patientsChart review of patientsExtracorporeal membrane oxygenation initiationMassive pulmonary embolismMedian ECMO durationReview of patientsRight heart strainRetrospective chart reviewSignificant hemodynamic compromisePERT programsLife-threatening diagnosisMassive PEECMO durationMedian agePE diagnosisHemodynamic compromiseSignificant morbidityHeart strainRisk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation
Tsushima T, Main A, Al-Kindi S, Dallan L, Wheat H, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S, Ohno Y, Lee K, Siqueira D, Kaneko T, Harloff M, Costa G, Barbanti M, Attizzani G. Risk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2022, 175: 80-87. PMID: 35597627, DOI: 10.1016/j.amjcard.2022.03.053.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionTranscatheter aortic valve implantationPersistent left bundle branch blockAssociated with cardiac mortalityNOP-LBBBLeft bundle branch blockLong-term outcomesBundle branch blockAortic valve implantationCardiac mortalityRisk stratificationComposite outcomeNew-onset persistent left bundle branch blockBranch blockValve implantationRetrospective study of patientsVentricular ejection fractionStudy of patientsHeart failure readmissionEjection fractionPermanent pacemakerRetrospective studyHeart failurePost-TAVIPatientsIdiopathic posterior papillary muscle rupture; a case report
Milioglou I, Janko M, Hassan H, ElHaq M, Filby S, Pelletier M. Idiopathic posterior papillary muscle rupture; a case report. BMC Cardiovascular Disorders 2022, 22: 151. PMID: 35387586, PMCID: PMC8988393, DOI: 10.1186/s12872-022-02570-4.Peer-Reviewed Original ResearchConceptsCase presentationA 73-year-old womanElevated serum troponin levelsEmergency mitral valve replacementFlail posterior mitral leafletSevere mitral regurgitationMitral valve replacementSerum troponin levelsPosterior mitral leafletST-segment changesChest painMitral regurgitationTroponin levelsValve replacementClinical presentationCoronary angiographyMitral leafletMuscle ruptureRare conditionConclusionThePresentationEchocardiographyRegurgitationAngiographyPainHypertensionEndoscopic vs Open Vein Harvest in Drug-Eluting Stents or Bypass Surgery for Left Main Disease Trial
Jarrett C, Pelletier M, Abu-Omar Y, Baeza C, Elgudin Y, Markowitz A, Vega P, Dressler O, Kappetein A, Serruys P, Stone G, Sabik J. Endoscopic vs Open Vein Harvest in Drug-Eluting Stents or Bypass Surgery for Left Main Disease Trial. The Annals Of Thoracic Surgery 2022, 115: 72-78. PMID: 35283098, DOI: 10.1016/j.athoracsur.2021.12.079.Peer-Reviewed Original ResearchConceptsEndoscopic vein harvesting groupCoronary artery bypass graftingOpen vein harvestingEndoscopic vein harvestingIschemia-driven revascularizationOpen vein harvested patientsBlood product transfusionComposite of deathGraft stenosisProduct transfusionVein harvestingEndoscopic vein harvest patientsOpen vein harvesting groupMyocardial infarctionOutcomes of coronary artery bypass graftingPrimary end pointArtery bypass graftingIn-hospital bleedingKaplan-Meier estimatesTime-to-first-event analysisDrug-eluting stentsBypass surgeryBypass graftingVenous graftsEnd points
2021
Postdischarge Pain and Opioid Use After Cardiac Surgery: A Prospective Cohort Study
Percy E, Hirji S, Leung N, Harloff M, Newell P, Cherkasky O, McGurk S, Yazdchi F, Cook R, Pelletier M, Kaneko T. Postdischarge Pain and Opioid Use After Cardiac Surgery: A Prospective Cohort Study. The Annals Of Thoracic Surgery 2021, 115: 1526-1532. PMID: 34979139, DOI: 10.1016/j.athoracsur.2021.12.007.Peer-Reviewed Original ResearchConceptsOpioid useCardiac surgeryOpioid consumptionRate of chronic opioid useOxycodone 5-mg tabletsPredictive of opioid useMedian total consumptionChronic opioid useMorphine milligram equivalentsPatterns of opioid consumptionMonths of surgeryProspective cohort studyConsecutive patientsMilligram equivalentsCardiac operationsHistory of substance useNonhome facilityPostdischarge painPill countDays of dischargePain managementCohort studyOpioidSurgeryPatient diariesMELD score is predictive of 90-day mortality after veno-arterial extracorporeal membrane oxygenation support
Karnib M, Haraf R, Tashtish N, Zanath E, Elshazly T, Garcia R, Billings S, Fetros M, Bradigan A, Zacharias M, Abu-Omar Y, Elgudin Y, Pelletier M, Al-Kindi S, Lytle F, ElAmm C. MELD score is predictive of 90-day mortality after veno-arterial extracorporeal membrane oxygenation support. The International Journal Of Artificial Organs 2021, 45: 404-411. PMID: 34702105, DOI: 10.1177/03913988211054865.Peer-Reviewed Original ResearchConceptsMELD-Na scoreVA-ECMOMELD scoreMELD-XIReceiver operating characteristicMELD-NaCardiogenic shockSingle-center retrospective reviewVeno-arterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenation supportMultivariate Cox regression analysisVeno-arterial extracorporeal membrane oxygenation supportVA-ECMO initiationLeft ventricular assist device placementVentricular assist device placementMELD-XI scoreExtracorporeal membrane oxygenationMembrane oxygenation supportMarker of survivalCox regression analysisPredictive of survivalLong-term mortalityChronic liver diseaseAssociated with mortalityECMO initiationRedo‐transcatheter aortic valve replacement with the supra‐annular, self‐expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry
Attizzani GF, Dallan LAP, Forrest JK, Reardon MJ, Szeto WY, Liu F, Pelletier M. Redo‐transcatheter aortic valve replacement with the supra‐annular, self‐expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry. Catheterization And Cardiovascular Interventions 2021, 99: 869-876. PMID: 34533891, DOI: 10.1002/ccd.29941.Peer-Reviewed Original ResearchConceptsTranscatheter Valve Therapy RegistryTranscatheter aortic valveRedo-TAVRTVT RegistryRedo transcatheter aortic valve replacementBetter short-term outcomesTotal aortic regurgitationAortic valve replacementLow-risk patientsShort-term outcomesHospital mortalityIndex hospitalizationAortic regurgitationValve replacementDevice successEvolut RSafety profileMyocardial infarctionAortic valveEvolut PROPatientsRegistryMean gradientOutcomesEvolut
2020
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Asher SR, Malzberg GW, Ong CS, Malapero RJ, Wang H, Shekar P, Kaneko T, Pelletier MP, Mallidi H, Heydarpour M, Shook DC, Shernan SK, Fox JA, Muehlschlegel JD, Xu X, Nguyen TB, Sundt TM, Body SC. Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality. Interdisciplinary CardioVascular And Thoracic Surgery 2020, 32: 9-19. PMID: 33313764, PMCID: PMC8600023, DOI: 10.1093/icvts/ivaa230.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationAortic valve replacementModerate mitral regurgitationMitral regurgitationMR severityPostoperative mortalityPreoperative transthoracicValve replacementEchocardiographic assessmentLong-term postoperative mortalityAortic valve replacement surgerySeverity of MRCoronary artery bypassLong-term mortalityValve replacement surgeryInduction of anesthesiaIschemic heart diseaseAortic valve diseaseProportional hazards regressionMitral valve repairPrediction of mortalityFunctional mitral regurgitation severityMitral regurgitation severityIntraoperative reassessmentArtery bypassAcute kidney injury in renal transplant recipients undergoing cardiac surgery
Hundemer G, Srivastava A, Jacob K, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel K, Hirji S, Pelletier M, Safa K, Kulvichit W, Kellum J, Riella L, Leaf D. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2020, 36: 185-196. PMID: 32892219, PMCID: PMC7771983, DOI: 10.1093/ndt/gfaa063.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsAcute kidney injuryNon-RTRsCardiac surgeryCalcineurin inhibitorsRisk factorsTransplant recipientsKidney injuryType of cardiac surgeryKidney diseaseRates of acute kidney injuryRisk of acute kidney injuryDeceased donorsGlobal Outcomes criteriaLiving donorsRetrospective cohort studyAssociated with higher ratesChronic kidney diseaseTrough levelsClinical characteristicsAcademic medical centerCohort studySurgeryHigh riskMedical CenterVariability in opioid prescribing practices among cardiac surgeons and trainees
Percy E, Hirji S, Cote C, Laurin C, Atkinson L, Kiehm S, Malarczyk A, Harloff M, Bozso S, Buyting R, Hassanabad A, Guo M, Jaffer I, Lodewyks C, Tam D, Tremblay P, Légaré J, Cook R, Kaneko T, Pelletier M. Variability in opioid prescribing practices among cardiac surgeons and trainees. Journal Of Cardiac Surgery 2020, 35: 2657-2662. PMID: 32720337, DOI: 10.1111/jocs.14885.Peer-Reviewed Original ResearchConceptsDischarge opioid prescriptionsOpioid prescriptionsCardiac surgeonsCardiac surgeryCanadian Society of Cardiac SurgeonsOpioid epidemicMedian total doseMorphine milligram equivalentsOpioid prescribing practicesAssociated with opioid use disorderDose of medicationOpioid use disorderMilligram equivalentsPrescribed opioidsOpioid medicationsTotal doseOpioidPrescription practicesPrescribing habitsUse disorderInterquartile rangeLack of formal educationPrescribing practicesSurgerySurgeonsSafety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement
Sheikh M, Deo S, Riaz H, Raza S, Altarabsheh S, Wilson B, Elgudin Y, Cmolik B, Pelletier M, Markowitz A. Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2020, 97: e425-e430. PMID: 32681697, DOI: 10.1002/ccd.29123.Peer-Reviewed Original ResearchConceptsValve replacementNational in-patient sampleLength of post-operative stayPropensity-matched cohort of patientsTrans-catheter aortic valve replacementPost-operative stayAortic valve replacementClinical co-variatesCohort of patientsAcute kidney injuryPropensity-matched cohortPost-procedural mortalityPost-procedural outcomesClinical outcomesKidney injurySecondary outcomesIn-patient samplePatientsLow-income patientsSafety-net hospitalHospitalOutcomesSafety-netIncome patientsNon-safety net hospitals
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