2024
The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
Shah A, Ding Y, Walji D, Rabinovich G, Pelletier M, El-Diasty M. The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review. Biomarkers 2024, 29: 485-493. PMID: 39422445, DOI: 10.1080/1354750x.2024.2415073.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAtrial FibrillationBiomarkersBlood ProteinsCardiac Surgical ProceduresGalectin 3GalectinsHumansPostoperative ComplicationsPrognosisConceptsAssociated with acute kidney injuryPostoperative atrial fibrillationGal-3 levelsLeft ventricular reverse remodelingCardiac surgeryAdverse outcomesGal-3Clinical risk prediction scorePreoperative plasma levelsVentricular reverse remodelingEuroSCORE II modelPlasma Gal-3 levelsPostoperative adverse outcomesAcute kidney injuryGalectin-3Group of patientsPredicting adverse outcomesRisk prediction scorePostoperative morbidityReverse remodelingPostoperative mortalityElectronic database searchPrognostic utilityAdult patientsKidney injuryPericardial fluid troponin in cardiac surgery
Fatehi Hassanabad A, El-Sherbini A, Cherif I, Ahmad B, Gonzalez A, Pelletier M, Fedak P, El-Diasty M. Pericardial fluid troponin in cardiac surgery. Clinica Chimica Acta 2024, 559: 119722. PMID: 38734224, DOI: 10.1016/j.cca.2024.119722.Peer-Reviewed Original ResearchConceptsCardiac surgeryPericardial fluidTroponin levelsLevels of cardiac troponinPF levelsCardiac troponin levelsTroponin changesGoogle Scholar databasesTroponin concentrationsCardiac troponinProcedure typeClinical significancePrimary outcomeSurgerySecondary outcomesBiologically active factorsBlinded reviewersPreferred Reporting ItemsFull-text reviewTroponinInclusion criteriaPatientsPathological changesScholar databasesSystematic review
2021
Postdischarge Pain and Opioid Use After Cardiac Surgery: A Prospective Cohort Study
Percy E, Hirji S, Leung N, Harloff M, Newell P, Cherkasky O, McGurk S, Yazdchi F, Cook R, Pelletier M, Kaneko T. Postdischarge Pain and Opioid Use After Cardiac Surgery: A Prospective Cohort Study. The Annals Of Thoracic Surgery 2021, 115: 1526-1532. PMID: 34979139, DOI: 10.1016/j.athoracsur.2021.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAnalgesics, OpioidCardiac Surgical ProceduresHumansOpioid-Related DisordersPain, PostoperativePatient DischargePractice Patterns, Physicians'Prospective StudiesConceptsOpioid useCardiac surgeryOpioid consumptionRate of chronic opioid useOxycodone 5-mg tabletsPredictive of opioid useMedian total consumptionChronic opioid useMorphine milligram equivalentsPatterns of opioid consumptionMonths of surgeryProspective cohort studyConsecutive patientsMilligram equivalentsCardiac operationsHistory of substance useNonhome facilityPostdischarge painPill countDays of dischargePain managementCohort studyOpioidSurgeryPatient diaries
2020
Acute kidney injury in renal transplant recipients undergoing cardiac surgery
Hundemer G, Srivastava A, Jacob K, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel K, Hirji S, Pelletier M, Safa K, Kulvichit W, Kellum J, Riella L, Leaf D. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2020, 36: 185-196. PMID: 32892219, PMCID: PMC7771983, DOI: 10.1093/ndt/gfaa063.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsAcute kidney injuryNon-RTRsCardiac surgeryCalcineurin inhibitorsRisk factorsTransplant recipientsKidney injuryType of cardiac surgeryKidney diseaseRates of acute kidney injuryRisk of acute kidney injuryDeceased donorsGlobal Outcomes criteriaLiving donorsRetrospective cohort studyAssociated with higher ratesChronic kidney diseaseTrough levelsClinical characteristicsAcademic medical centerCohort studySurgeryHigh riskMedical CenterVariability in opioid prescribing practices among cardiac surgeons and trainees
Percy E, Hirji S, Cote C, Laurin C, Atkinson L, Kiehm S, Malarczyk A, Harloff M, Bozso S, Buyting R, Hassanabad A, Guo M, Jaffer I, Lodewyks C, Tam D, Tremblay P, Légaré J, Cook R, Kaneko T, Pelletier M. Variability in opioid prescribing practices among cardiac surgeons and trainees. Journal Of Cardiac Surgery 2020, 35: 2657-2662. PMID: 32720337, DOI: 10.1111/jocs.14885.Peer-Reviewed Original ResearchConceptsDischarge opioid prescriptionsOpioid prescriptionsCardiac surgeonsCardiac surgeryCanadian Society of Cardiac SurgeonsOpioid epidemicMedian total doseMorphine milligram equivalentsOpioid prescribing practicesAssociated with opioid use disorderDose of medicationOpioid use disorderMilligram equivalentsPrescribed opioidsOpioid medicationsTotal doseOpioidPrescription practicesPrescribing habitsUse disorderInterquartile rangeLack of formal educationPrescribing practicesSurgerySurgeonsThirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery
Hirji SA, Percy ED, Zogg CK, Vaduganathan M, Kiehm S, Pelletier M, Kaneko T. Thirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery. The Annals Of Thoracic Surgery 2020, 110: 484-491. PMID: 31972128, PMCID: PMC7382395, DOI: 10.1016/j.athoracsur.2019.11.042.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCardiac Surgical ProceduresFemaleHumansMaleMiddle AgedPatient ReadmissionRetrospective StudiesRisk FactorsTreatment OutcomeYoung AdultConceptsSurgical aortic valve replacementNonindex readmissionsCardiac surgeryNonindex hospitalNonindex hospital readmissionsCoronary artery bypassNational Readmission DatabaseAortic valve replacementCardiac surgery patientsMajor cardiac surgeryPatient risk profileHigh-volume centersUS adult patientsRegionalization of careFragmentation of careComorbidity burdenHospital mortalityIndex readmissionArtery bypassInitial hospitalizationAdult patientsSurgery patientsValve replacementHospital readmissionIndependent predictors
2019
Cardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries
Shah R, Hirji S, Percy E, Landino S, Yazdchi F, Bellavia A, Pelletier M, Shekar P, Kaneko T. Cardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries. The Annals Of Thoracic Surgery 2019, 109: 1194-1201. PMID: 31479643, DOI: 10.1016/j.athoracsur.2019.07.041.Peer-Reviewed Original ResearchConceptsOpioid use disorderCardiac surgeryIncreased risk of postoperative morbidityImpact of opioid use disorderRisk of postoperative morbidityOpioid epidemicAssociated with prolonged hospitalizationRisk factorsUse disorderOpioid use disorder statusCoronary artery bypass graftingNon-opioid usersPreoperative risk factorsCardiac surgery patientsPatient's preoperative risk factorsAcute kidney injuryArtery bypass graftingCardiac surgery outcomesIn-hospital mortalityCurrent opioid epidemicLonger hospital lengthImprove overall outcomesHigher hospital costsNational Inpatient SampleValve repairDebunking the July Effect in Cardiac Surgery: A National Analysis of More Than 470,000 Procedures
Shah RM, Hirji SA, Kiehm S, Goel S, Yazdchi F, Bellavia A, Zogg CK, Pelletier MP, Shekar P, Kaneko T. Debunking the July Effect in Cardiac Surgery: A National Analysis of More Than 470,000 Procedures. The Annals Of Thoracic Surgery 2019, 108: 929-934. PMID: 31353035, DOI: 10.1016/j.athoracsur.2019.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedCardiac Surgical ProceduresClinical CompetenceCohort StudiesDatabases, FactualEducation, Medical, GraduateFemaleHospital MortalityHospitals, TeachingHumansInpatientsInternship and ResidencyMaleMedical Staff, HospitalMiddle AgedPostoperative ComplicationsQuality of Health CareRisk AdjustmentSeasonsUnited StatesConceptsAortic valve replacementCardiac surgeryJuly effectHospital mortalityPatient outcomesTeaching hospitalMajor cardiac surgery proceduresSurgical aortic valve replacementCoronary artery bypassCardiac surgery proceduresNational Inpatient SampleRisk-adjusted mortalityMitral valve repairCardiac surgery outcomesHospital complicationsArtery bypassMV surgeryNoncardiac surgeryValve replacementAdjusted mortalityValve repairSurgery outcomesInpatient SampleWorse outcomesHospital support systemsSignificance of Interstitial Lung Disease on Outcomes Following Cardiac Surgery
Hirji S, Ramirez-Del Val F, Ejiofor J, Lee J, Norman A, McGurk S, Pelletier M, Aranki S, Rawn J, Shekar P, Hunninghake G, Kaneko T. Significance of Interstitial Lung Disease on Outcomes Following Cardiac Surgery. The American Journal Of Cardiology 2019, 124: 1133-1139. PMID: 31405546, DOI: 10.1016/j.amjcard.2019.06.031.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseInterstitial lung disease patientsIdiopathic pulmonary fibrosisLong-term survivalLonger intensive care unitCardiac surgeryNon-ILD patientsIntensive care unitReintubation rateAssociated with shorter long-term survivalLung diseaseComparison cohortSeverity of interstitial lung diseaseShorter long-term survivalCare unitKaplan-Meier estimates of survivalIdiopathic pulmonary fibrosis cohortsRisk factorsInterstitial lung disease diagnosisSurvival analysisAcute pulmonary exacerbationsIncreased operative mortalityMedian follow-upCardiac surgery patientsRisk-adjusted survival analysis
2018
A Successful Opioid-Free Anesthetic in a Patient Undergoing Cardiac Surgery
Landry E, Burns S, Pelletier M, Muehlschlegel J. A Successful Opioid-Free Anesthetic in a Patient Undergoing Cardiac Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 2517-2520. PMID: 30611614, DOI: 10.1053/j.jvca.2018.11.040.Peer-Reviewed Original ResearchAgedAnalgesics, OpioidAnestheticsCardiac Surgical ProceduresFemaleHumansPain, PostoperativeTreatment Outcome
2017
From sutures to wires: The evolving necessities of cardiac surgery training
Pelletier M, Kaneko T, Peterson M, Thourani V. From sutures to wires: The evolving necessities of cardiac surgery training. Journal Of Thoracic And Cardiovascular Surgery 2017, 154: 990-993. PMID: 28645829, DOI: 10.1016/j.jtcvs.2017.03.157.Peer-Reviewed Original Research
2016
Efficacy of intraoperative cell salvage in decreasing perioperative blood transfusion rates in first-time cardiac surgery patients: a retrospective study
Côté C, Yip A, MacLeod J, O'Reilly B, Murray J, Ouzounian M, Brown C, Forgie R, Pelletier M, Hassan A. Efficacy of intraoperative cell salvage in decreasing perioperative blood transfusion rates in first-time cardiac surgery patients: a retrospective study. Canadian Journal Of Surgery 2016, 59: 330-336. PMID: 27668331, PMCID: PMC5042720, DOI: 10.1503/cjs.002216.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood TransfusionCardiac Surgical ProceduresFemaleHumansMaleOperative Blood SalvageOutcome and Process Assessment, Health CarePerioperative CareRetrospective StudiesConceptsIntraoperative cell salvagePerioperative transfusion ratesCardiac surgeryTransfusion rateCell salvageTransfusion rates of packed red blood cellsRates of packed red blood cellsBlood productsFirst-time cardiac surgeryRetrospective analysis of patientsEffectiveness of intraoperative cell salvagePerioperative blood transfusion ratePacked red blood cellsBlood transfusion rateCardiac surgery patientsAnalysis of patientsReduce transfusion ratesRisk-adjusted effectCoagulation productsMultivariate logistic regressionPerioperative transfusionMediastinal drainagePostoperative bleedingPostoperative hemoglobinHematologic outcomes
2015
Increased Distance From the Tertiary Cardiac Center Is Associated With Worse 30-Day Outcomes After Cardiac Operations
Cote C, Singh S, Yip A, Murray J, MacLeod J, Lutchmedial S, Brown C, Forgie R, Pelletier M, Hassan A. Increased Distance From the Tertiary Cardiac Center Is Associated With Worse 30-Day Outcomes After Cardiac Operations. The Annals Of Thoracic Surgery 2015, 100: 2213-2218. PMID: 26271578, DOI: 10.1016/j.athoracsur.2015.05.058.Peer-Reviewed Original ResearchConceptsTertiary cardiac care centerCardiac operationsCardiac care centerIn-hospitalNonemergent cardiac operationsCare centerRisk of adverse outcomesEffect of driving distanceTertiary cardiac centerIn-hospital outcomesMultivariate logistic regressionCardiac centerRetrospective analysisFollow-upAdverse outcomesPatient groupPatientsStudy populationLogistic regressionCardiovascular carePatient's homeOutcomesResidents
2014
Variation in transfusion rates within a single institution: Exploring the effect of differing practice patterns on the likelihood of blood product transfusion in patients undergoing cardiac surgery
Cote C, MacLeod J, Yip A, Ouzounian M, Brown C, Forgie R, Pelletier M, Hassan A. Variation in transfusion rates within a single institution: Exploring the effect of differing practice patterns on the likelihood of blood product transfusion in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 297-302. PMID: 25300883, DOI: 10.1016/j.jtcvs.2014.09.004.Peer-Reviewed Original ResearchConceptsRate of perioperative transfusionPerioperative transfusion ratesPerioperative transfusionTransfusion rateCardiac surgeryPractice patternsIntraoperative variablesPredictors of perioperative transfusionPredictors of blood transfusionOverall transfusion rateBlood product transfusionRisk-adjusted effectYear of procedureProduct transfusionBlood transfusionClinical predictorsIndependent predictorsClinical characteristicsClinical factorsTransfusionPatientsStudy populationSurgeryMultivariable regression modeling techniquesNonclinical factors
2008
Factor Eight Inhibitor Bypassing Activity (FEIBA) for Refractory Bleeding in Cardiac Surgery: Review of Clinical Outcomes
Balsam L, Timek T, Pelletier M. Factor Eight Inhibitor Bypassing Activity (FEIBA) for Refractory Bleeding in Cardiac Surgery: Review of Clinical Outcomes. Journal Of Cardiac Surgery 2008, 23: 614-621. PMID: 18793226, DOI: 10.1111/j.1540-8191.2008.00686.x.Peer-Reviewed Original ResearchConceptsChest tube outputBlood product utilizationPostoperative bleedingTube outputReview of clinical outcomesAdministration of blood productsAdministration of FEIBACardiac surgical proceduresInhibitor bypassing activityMultisystem organ failureCardiac surgery programFEIBA administrationRefractory bleedingCardiac surgerySurgical reexplorationRetrospective reviewRespiratory failureThrombotic eventsClinical outcomesMultiple dosesSingle doseFEIBAOrgan failureOperative reexplorationExtremity ischemia
2006
The Future of Cardiac Surgery Training Programs
Dunnington G, Pelletier M. The Future of Cardiac Surgery Training Programs. The Annals Of Thoracic Surgery 2006, 81: 1179-1180. PMID: 16488764, DOI: 10.1016/j.athoracsur.2005.07.025.Peer-Reviewed Original Research
2002
Alternative approach for use of a left ventricular assist device with a thrombosed prosthetic valve
Pelletier M, Chang C, Vagelos R, Robbins R. Alternative approach for use of a left ventricular assist device with a thrombosed prosthetic valve. The Journal Of Heart And Lung Transplantation 2002, 21: 402-404. PMID: 11897531, DOI: 10.1016/s1053-2498(01)00354-0.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceVentricular assist deviceIncreased risk of thrombosisAortic outflow tractBovine pericardial patchTreating similar patientsRisk of thrombosisThrombosed prosthetic valveMechanical aortic valveProsthetic heart valvesOutflow tractPericardial patchAortic valveProsthetic valvesIncreased riskAssist devicePatientsHeart valves
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