2024
Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, Al‐Kindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction disease
2020
Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement
Sheikh M, Deo S, Riaz H, Raza S, Altarabsheh S, Wilson B, Elgudin Y, Cmolik B, Pelletier M, Markowitz A. Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2020, 97: e425-e430. PMID: 32681697, DOI: 10.1002/ccd.29123.Peer-Reviewed Original ResearchConceptsValve replacementNational in-patient sampleLength of post-operative stayPropensity-matched cohort of patientsTrans-catheter aortic valve replacementPost-operative stayAortic valve replacementClinical co-variatesCohort of patientsAcute kidney injuryPropensity-matched cohortPost-procedural mortalityPost-procedural outcomesClinical outcomesKidney injurySecondary outcomesIn-patient samplePatientsLow-income patientsSafety-net hospitalHospitalOutcomesSafety-netIncome patientsNon-safety net hospitalsSex-based differences in mitral valve Re-operation after mitral valve repair: Truth or myth?
Hirji S, Guetter C, Trager L, Yazdchi F, Landino S, Lee J, Anastasopulos A, Percy E, McGurk S, Pelletier M, Aranki S, Shekar P, Kaneko T. Sex-based differences in mitral valve Re-operation after mitral valve repair: Truth or myth? The American Journal Of Surgery 2020, 220: 1344-1350. PMID: 32788080, DOI: 10.1016/j.amjsurg.2020.06.069.Peer-Reviewed Original ResearchConceptsRe-operation riskRe-operationMV repairRheumatic diseasesFemale sexMitral valve re-operationMV repair durabilityMedian follow-upMitral valve repairAssociated with rheumatic diseasesSTS risk scoreOperative mortalityValve repairPreoperative profilesAdult patientsFollow-upDisease progressionSex-based differencesRepair durabilityRepair failureWomenRepairRiskLongitudinal analysisSexQuantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation
Hirji SA, Zogg CK, Vaduganathan M, Kiehm S, Percy ED, Yazdchi F, Pelletier M, Shah PB, Bhatt DL, O'Gara P, Kaneko T. Quantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 128: 113-119. PMID: 32650903, DOI: 10.1016/j.amjcard.2020.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCenters for Medicare and Medicaid Services, U.S.ComorbidityContinuity of Patient CareCoronary AngiographyDiabetes MellitusFemaleHospital CostsHospital MortalityHospitalsHumansHypertensionLength of StayLung DiseasesMaleMultivariate AnalysisPacemaker, ArtificialPatient ReadmissionPericardiocentesisPostoperative ComplicationsProsthesis ImplantationStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsNonindex hospitalNonindex readmissionsCare fragmentationTranscatheter aortic valve implantation outcomesTranscatheter aortic valve implantationHigher co-morbidity burdenNational Readmission DatabaseAortic valve implantationCo-morbidity burdenTotal hospital costsMajor cardiac proceduresUS adult patientsFuture health policyValue of careIndex readmissionTAVI patientsCause mortalityIndex hospitalNoncardiac causesAdult patientsPatient characteristicsReadmission ratesValve implantationReadmission lengthCardiac proceduresUtility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes
Hirji S, McGurk S, Kiehm S, Ejiofor J, Val F, Kolkailah A, Berry N, Sobieszczyk P, Pelletier M, Shah P, O’Gara P, Kaneko T. Utility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes. JAMA Cardiology 2020, 5: 156-165. PMID: 31851293, PMCID: PMC6990722, DOI: 10.1001/jamacardio.2019.4657.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementSurgical aortic valve replacement proceduresAortic valve replacementHospital performanceEvaluation of hospital performanceValve replacementHospital performance rankingsCohort study analyzed dataMeasure hospital performanceConcomitant coronary artery bypass graftingCoronary artery bypass graftingProcedure-related mortalityOpen-heart proceduresStudy analyzed dataPatient risk profileSurgical aortic valve replacement outcomesTAVR admissionsArtery bypass graftingMedicare beneficiariesMain OutcomesReplacement outcomesOutcome metricsRisk adjustmentBypass graftingRelationship Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes
Hirji S, McCarthy E, Kim D, McGurk S, Ejiofor J, Val F, Kolkailah A, Rosner B, Shook D, Nyman C, Berry N, Sobieszczyk P, Pelletier M, Shah P, O’Gara P, Kaneko T. Relationship Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes. JACC Cardiovascular Interventions 2020, 13: 335-343. PMID: 32029250, PMCID: PMC8858441, DOI: 10.1016/j.jcin.2019.09.048.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveClinical CompetenceDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHospitals, High-VolumeHospitals, Low-VolumeHumansMaleMedicareOutcome and Process Assessment, Health CareQuality Indicators, Health CareRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementSurgical aortic valve replacementTranscatheter aortic valve replacement outcomesAortic valve replacementValve replacementConcomitant coronary artery bypass graft surgeryGroup 2Aortic valve replacement volumesGroup 1Group 3Group 4Surgical aortic valve replacement volumeCoronary artery bypass graft surgeryTranscatheter aortic valve replacement procedureArtery bypass graft surgeryAortic valve replacement proceduresYear post-procedureOpen-heart proceduresRisk-adjusted odds ratioMultivariate Cox regressionHeart valve proceduresLow-volume centersValve replacement proceduresTAVR admissionsBypass graft surgeryOutcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty
Hirji S, Yazdchi F, Kiehm S, Landino S, McGurk S, Muehlschlegel J, Singh S, Mallidi H, Pelletier M, Aranki S, Shekar P, Kaneko T. Outcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty. The Annals Of Thoracic Surgery 2020, 110: 821-828. PMID: 32001230, DOI: 10.1016/j.athoracsur.2019.12.023.Peer-Reviewed Original ResearchConceptsTricuspid valve repairEvent-free survivalTricuspid valve reoperationValve repairTR recurrenceValve reoperationTricuspid regurgitationConcomitant aortic valveCoronary artery bypass grafting proceduresFunctional tricuspid regurgitationTricuspid valve insufficiencyTricuspid valve replacementDevice placement procedureConventional surgical techniquesIn-hospital outcomesBypass grafting proceduresBicuspidization techniqueAortic proceduresRing annuloplastyMidterm outcomesValve insufficiencyValve replacementEchocardiographic profileHeart transplantationMitral valveTranscatheter vs surgical aortic valve replacement in patients with interstitial lung disease
Hirji S, Cote C, Lee J, Kiehm S, McGurk S, Pelletier M, Aranki S, Shekar P, Shah P, Kaneko T. Transcatheter vs surgical aortic valve replacement in patients with interstitial lung disease. Journal Of Cardiac Surgery 2020, 35: 571-579. PMID: 31981435, DOI: 10.1111/jocs.14421.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementInterstitial lung diseaseAortic valve replacementTranscatheter aortic valve replacement patientsIntensive care unitSurgical aortic valve replacement patientsInterstitial lung disease patientsShorter ventilation timeValve replacementOperative mortalityAortic stenosisVentilation timeLung diseaseRisk of postoperative pulmonary complicationsIsolated surgical aortic valve replacementDiagnosis of interstitial lung diseaseAssociated with significantly shorter hospitalRate of postoperative strokeIntensive care unit admissionPostoperative pulmonary complicationsSignificantly shorter hospitalSevere aortic stenosisPermanent pacemaker implantationSymptomatic aortic stenosisThirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery
Hirji SA, Percy ED, Zogg CK, Vaduganathan M, Kiehm S, Pelletier M, Kaneko T. Thirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery. The Annals Of Thoracic Surgery 2020, 110: 484-491. PMID: 31972128, PMCID: PMC7382395, DOI: 10.1016/j.athoracsur.2019.11.042.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementNonindex readmissionsCardiac surgeryNonindex hospitalNonindex hospital readmissionsCoronary artery bypassNational Readmission DatabaseAortic valve replacementCardiac surgery patientsMajor cardiac surgeryPatient risk profileHigh-volume centersUS adult patientsRegionalization of careFragmentation of careComorbidity burdenHospital mortalityIndex readmissionArtery bypassInitial hospitalizationAdult patientsSurgery patientsValve replacementHospital readmissionIndependent predictors
2019
Comparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States
Shah R, Hirji S, Jolissaint J, Lander H, Shah P, Pelletier M, Sobieszczyk P, Berry N, Shook D, Nyman C, Bhatt D, Body S, Kaneko T. Comparison of Sex-Based Differences in Home or Nonhome Discharge Utilization of Rehabilitative Services and Outcomes Following Transcatheter Aortic Valve Implantation in the United States. The American Journal Of Cardiology 2019, 123: 1983-1991. PMID: 30952379, DOI: 10.1016/j.amjcard.2019.03.008.Peer-Reviewed Original ResearchConceptsRehabilitation facilitySex-based differencesRehabilitation service utilizationCo-morbiditiesTranscatheter aortic valve implantationFemale sexElixhauser co-morbiditiesHospital costsDischarged to homeBody mass indexMultivariate logistic regressionNational Inpatient Sample databaseHome-discharged patientsService utilizationChronic conditionsAortic valve implantationInpatient Sample databaseHigher hospital costsIn-hospital mortalityInpatient admissionsDischarged patientsRehabilitationMass indexLogistic regressionPatient outcomes
2018
Minimally invasive versus full sternotomy aortic valve replacement in low-risk patients: Which will stand against transcatheter aortic valve replacement?
Hirji S, Funamoto M, Lee J, Ramirez Del Val F, Kolkailah A, McGurk S, Pelletier M, Aranki S, Shekar P, Kaneko T. Minimally invasive versus full sternotomy aortic valve replacement in low-risk patients: Which will stand against transcatheter aortic valve replacement? Surgery 2018, 164: 282-287. PMID: 29699805, DOI: 10.1016/j.surg.2018.02.018.Peer-Reviewed Original ResearchConceptsMinimally invasive aortic valve replacementAortic valve replacement patientsAortic valve replacementLow-risk patientsMinimally invasive aortic valve replacement patientsValve replacement patientsSternotomy aortic valve replacementIntensive care unitTranscatheter aortic valve replacementValve replacementCongestive heart failureCare unitReoperation rateHeart failureElective isolated aortic valve replacementHospital lengthReplacement patientsAortic valve replacement resultsMedian intensive care unitShorter intensive care unitPredictors of decreased survivalShorter median intensive care unitValve replacement resultsAssociated with improved resultsPredicted risk of mortalityNovel fast-track recovery protocol for alternative access transcatheter aortic valve replacement: application to non-femoral approaches
Kolkailah A, Hirji S, Ejiofor J, Del Val F, Lee J, Norman A, McGurk S, Mahmood S, Shook D, Vlassakov K, Nyman C, Shah P, Pelletier M, Kaneko T. Novel fast-track recovery protocol for alternative access transcatheter aortic valve replacement: application to non-femoral approaches. Interdisciplinary CardioVascular And Thoracic Surgery 2018, 26: 938-943. PMID: 29365108, DOI: 10.1093/icvts/ivx409.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementPre-fast-trackAortic valve replacementAlternative access transcatheter aortic valve replacementValve replacementIntensive care unitFT protocolCare unitShorter intensive care unitMultidisciplinary heart team approachIntensive care unit timeFast-track (FTFast-track recovery protocolTranscatheter aortic valve replacement utilizationHeart team approachEnhance patient recoveryComparison of outcomesIncreased procedural complicationsFT patientsProcedural complicationsTranscatheterPatientsTransfemoral approachIliofemoral vesselsPatient recoveryClinical Significance of Greater Implantation Height with SAPIEN 3 Transcatheter Heart Valve.
Ramirez Del Val F, Hirji S, Carreras E, Kolkailah A, Chowdhury R, McGurk S, Lee J, Nyman C, Shook D, Sobieszczyk P, Pelletier M, Shah P, Kaneko T. Clinical Significance of Greater Implantation Height with SAPIEN 3 Transcatheter Heart Valve. The Journal Of Heart Valve Disease 2018, 27: 9-16. PMID: 30560594.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementRight bundle branch blockPreoperative right bundle branch blockPermanent pacemaker implantationRate of PPM implantationSAPIEN 3 valvePermanent pacemakerPPM implantationOperative mortalityHigher implantationHI patientsSociety of Thoracic Surgeons Predicted RiskClinical significanceAssociated with PPM implantationImplant heightTranscatheter aortic valve replacement patientsThoracic Surgeons Predicted RiskRates of permanent pacemakerStandard implantsIncreased operative mortalityAortic valve replacementLong-term followTranscatheter heart valveBundle branch blockValve replacement
2017
Impact of flow, gradient, and left ventricular function on outcomes after transcatheter aortic valve replacement
Carreras E, Kaneko T, Val F, Pelletier M, Sobieszczyk P, Bhatt D, Shah P. Impact of flow, gradient, and left ventricular function on outcomes after transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2017, 91: 798-805. PMID: 28988432, PMCID: PMC5849510, DOI: 10.1002/ccd.27347.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBostonFemaleHeart FailureHospital MortalityHumansLength of StayMaleRecovery of FunctionRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsTranscatheter aortic valve replacementAortic valve replacementStroke volume indexHeart failureReduced LVEFValve replacementIncreased mortalityOutcomes similar to patientsTranscatheter aortic valve replacement patientsPredictor of 1-year mortalityAssociated with increased mortalityOutcomes of patientsLeft ventricular functionSimilar to patientsReduced EFVentricular functionLVEFClinical factorsWomen's HospitalVolume indexPatientsAssociated with increasesMortalityTranscatheterOutcomesAspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomized Clinical Trial
Rodés-Cabau J, Masson J, Welsh R, del Blanco B, Pelletier M, Webb J, Al-Qoofi F, Généreux P, Maluenda G, Thoenes M, Paradis J, Chamandi C, Serra V, Dumont E, Côté M. Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomized Clinical Trial. JACC Cardiovascular Interventions 2017, 10: 1357-1365. PMID: 28527771, DOI: 10.1016/j.jcin.2017.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAspirinBalloon ValvuloplastyCanadaClopidogrelDrug Therapy, CombinationEarly Termination of Clinical TrialsEuropeFemaleFibrinolytic AgentsHeart Valve ProsthesisHemorrhageHumansIschemic Attack, TransientKaplan-Meier EstimateMaleMyocardial InfarctionPlatelet Aggregation InhibitorsProsthesis DesignRisk FactorsSouth AmericaStrokeThrombosisTiclopidineTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementTransient ischemic attackLife-threatening bleedingAortic valve replacementBalloon-expandable valveOccurrence of deathMyocardial infarctionIschemic attackBleeding eventsValve replacementAntithrombotic treatmentClinical trialsLife-threatening bleeding eventsPrevention of ischemic eventsOptimal antithrombotic therapyComposite of deathRandomized clinical trialsPlanned study populationLife-threatening eventsRandomized controlled trialsCompared aspirinPrimary endpointAntithrombotic therapyPost-TAVRAdverse eventsLeaflet Thrombosis in Surgically Explanted or Post-Mortem TAVR Valves
Mangione F, Jatene T, Gonçalves A, Fishbein G, Mitchell R, Pelletier M, Kaneko T, Shah P, Nyman C, Shook D, Blankstein R, Padera R, Bhatt D. Leaflet Thrombosis in Surgically Explanted or Post-Mortem TAVR Valves. JACC Cardiovascular Imaging 2017, 10: 82-85. PMID: 28057222, DOI: 10.1016/j.jcmg.2016.11.009.Peer-Reviewed Original ResearchTranscatheter aortic valve replacement with the Portico valve: one-year results of the early Canadian experience.
Perlman G, Cheung A, Dumont E, Stub D, Dvir D, Del Trigo M, Pelletier M, Alnasser S, Ye J, Wood D, Thompson C, Blanke P, Leipsic J, Seidman M, LeBlanc H, Buller C, Rodés-Cabau J, Webb J. Transcatheter aortic valve replacement with the Portico valve: one-year results of the early Canadian experience. EuroIntervention 2017, 12: 1653-1659. PMID: 28105999, DOI: 10.4244/eij-d-16-00299.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementPortico valveOutcomes of transcatheter aortic valve replacementFirst-in-human experienceSociety of Thoracic SurgeonsModerate/severe aortic regurgitationMedium-term outcomesOne-year resultsRisk of mortalityYears of ageAortic regurgitationEchocardiographic findingsThoracic surgeonsClinical resultsClinical reviewPatientsSelf-expandingEchocardiographyTranscatheterValveDaysRegurgitationShort-
2014
Sutureless Aortic Valve Replacement: A Canadian Multicentre Study
Mazine A, Teoh K, Bouhout I, Bhatnagar G, Pelletier M, Voisine P, Demers P, Carrier M, Bouchard D. Sutureless Aortic Valve Replacement: A Canadian Multicentre Study. Canadian Journal Of Cardiology 2014, 31: 63-68. PMID: 25547552, DOI: 10.1016/j.cjca.2014.10.030.Peer-Reviewed Original ResearchConceptsSutureless aortic valve replacementAortic valve replacementParavalvular aortic insufficiencyAortic insufficiencyAlternative to standard aortic valve replacementElderly high-risk surgical patientsStandard aortic valve replacementIsolated aortic valve replacementRisk of permanent pacemaker implantationHigh-risk surgical patientsMultiple valve proceduresPerceval S bioprosthesisPerceval S prosthesisCoronary artery bypass graftingCross-clamp timePermanent pacemaker implantationShorter operative timeCanadian multicenter studyArtery bypass graftingIn-hospital mortalitySeptal myectomyEchocardiographic outcomesPartial sternotomyConcomitant proceduresConsecutive patients
2008
Factor Eight Inhibitor Bypassing Activity (FEIBA) for Refractory Bleeding in Cardiac Surgery: Review of Clinical Outcomes
Balsam L, Timek T, Pelletier M. Factor Eight Inhibitor Bypassing Activity (FEIBA) for Refractory Bleeding in Cardiac Surgery: Review of Clinical Outcomes. Journal Of Cardiac Surgery 2008, 23: 614-621. PMID: 18793226, DOI: 10.1111/j.1540-8191.2008.00686.x.Peer-Reviewed Original ResearchConceptsChest tube outputBlood product utilizationPostoperative bleedingTube outputReview of clinical outcomesAdministration of blood productsAdministration of FEIBACardiac surgical proceduresInhibitor bypassing activityMultisystem organ failureCardiac surgery programFEIBA administrationRefractory bleedingCardiac surgerySurgical reexplorationRetrospective reviewRespiratory failureThrombotic eventsClinical outcomesMultiple dosesSingle doseFEIBAOrgan failureOperative reexplorationExtremity ischemia
2002
Paraplegia After Routine Cardiac Surgery: A Rare Complication
Pelletier M, Al‐Khaldi A, Berry G, Morin J. Paraplegia After Routine Cardiac Surgery: A Rare Complication. Journal Of Cardiac Surgery 2002, 17: 410-412. PMID: 12630541, DOI: 10.1111/j.1540-8191.2001.tb01170.x.Peer-Reviewed Original ResearchConceptsCase of spinal cord infarctionRoutine cardiac surgerySpinal cord infarctionClinical paraplegiaCardiac surgeryCord infarctionRare complicationPeripheral embolismCardiopulmonary bypassCardiac proceduresPrimary etiologyEtiologyParaplegiaEmbolizationSurgeryComplicationsCardiopulmonaryPatientsBypassInfarctionCases
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