2024
Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement
Feroze R, Kang P, Dallan L, Akula N, Galo J, Yoon S, Ukaigwe A, Filby S, Baeza C, Pelletier M, Rushing G, Rajagopalan S, Al‐Kindi S, Rashid I, Attizzani G. Elevated myocardial extracellular volume fraction is associated with the development of conduction pathway defects following transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2024, 104: 1119-1128. PMID: 38952304, DOI: 10.1002/ccd.31136.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedAged, 80 and overAortic ValveAortic Valve StenosisArea Under CurveAtrioventricular BlockBundle-Branch BlockCardiac Pacing, ArtificialFemaleFibrosisHeart Conduction SystemHumansMagnetic Resonance Imaging, CineMaleMyocardiumPacemaker, ArtificialPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementCardiac magnetic resonance imagingLate gadolinium enhancementRight bundle branch blockArea under the receiver operating characteristic curveAortic valve replacementReceiver operating curveMyocardial fibrosisPost-TAVRConduction defectsBundle branch blockAssociations of myocardial fibrosisExtracellular volumeConduction diseaseValve replacementGadolinium enhancementPermanent pacemakerConduction abnormalitiesConduction deficitsHeart blockBranch blockRisk of heart blockSeptal late gadolinium enhancementMyocardial extracellular volume fractionBaseline conduction disease
2023
Clinical impact of right ventricular pacing burden in patients with post-transcatheter aortic valve replacement permanent pacemaker implantation
Tsushima T, Al-Kindi S, Dallan L, Fares A, Yoon S, Wheat H, Attizzani G, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S. Clinical impact of right ventricular pacing burden in patients with post-transcatheter aortic valve replacement permanent pacemaker implantation. EP Europace 2023, 25: 1441-1450. PMID: 36794441, PMCID: PMC10105841, DOI: 10.1093/europace/euad025.Peer-Reviewed Original ResearchConceptsRight ventricular pacing burdenTranscatheter aortic valve replacementVentricular pacing burdenPermanent pacemaker implantationPermanent pacemakerHeart failurePacing burdenPPM implantationRetrospective study of consecutive patientsLikelihood of heart failureStudy of consecutive patientsLeft ventricular ejection fractionAssociated with worse outcomesVentricular ejection fractionAortic valve replacementAtrial fibrillation burdenValve implantation depthConsecutive patientsEjection fractionValve replacementPost-TAVRClinical benefitPacemaker implantationRetrospective studySingle-centre
2022
Percutaneous mechanical thrombectomy and extracorporeal membranous oxygenation: A case series
Mously H, Hajjari J, Chami T, Hammad T, Schilz R, Carman T, Elgudin Y, Abu‐Omar Y, Pelletier M, Shishehbor M, Li J. Percutaneous mechanical thrombectomy and extracorporeal membranous oxygenation: A case series. Catheterization And Cardiovascular Interventions 2022, 100: 274-278. PMID: 35686535, DOI: 10.1002/ccd.30295.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedExtracorporeal Membrane OxygenationHeart ArrestHumansMiddle AgedPulmonary EmbolismRetrospective StudiesThrombectomyTreatment OutcomeConceptsPulmonary Embolism Response TeamExtracorporeal membrane oxygenationPulmonary embolismFollow-up periodCardiac arrestPulmonary embolism response team activationHigh-risk pulmonary embolismRetrospective chart review of patientsChart review of patientsExtracorporeal membrane oxygenation initiationMassive pulmonary embolismMedian ECMO durationReview of patientsRight heart strainRetrospective chart reviewSignificant hemodynamic compromisePERT programsLife-threatening diagnosisMassive PEECMO durationMedian agePE diagnosisHemodynamic compromiseSignificant morbidityHeart strainRisk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation
Tsushima T, Main A, Al-Kindi S, Dallan L, Wheat H, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S, Ohno Y, Lee K, Siqueira D, Kaneko T, Harloff M, Costa G, Barbanti M, Attizzani G. Risk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2022, 175: 80-87. PMID: 35597627, DOI: 10.1016/j.amjcard.2022.03.053.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionTranscatheter aortic valve implantationPersistent left bundle branch blockAssociated with cardiac mortalityNOP-LBBBLeft bundle branch blockLong-term outcomesBundle branch blockAortic valve implantationCardiac mortalityRisk stratificationComposite outcomeNew-onset persistent left bundle branch blockBranch blockValve implantationRetrospective study of patientsVentricular ejection fractionStudy of patientsHeart failure readmissionEjection fractionPermanent pacemakerRetrospective studyHeart failurePost-TAVIPatients
2021
MELD score is predictive of 90-day mortality after veno-arterial extracorporeal membrane oxygenation support
Karnib M, Haraf R, Tashtish N, Zanath E, Elshazly T, Garcia R, Billings S, Fetros M, Bradigan A, Zacharias M, Abu-Omar Y, Elgudin Y, Pelletier M, Al-Kindi S, Lytle F, ElAmm C. MELD score is predictive of 90-day mortality after veno-arterial extracorporeal membrane oxygenation support. The International Journal Of Artificial Organs 2021, 45: 404-411. PMID: 34702105, DOI: 10.1177/03913988211054865.Peer-Reviewed Original ResearchMeSH KeywordsEnd Stage Liver DiseaseExtracorporeal Membrane OxygenationHospital MortalityHumansRetrospective StudiesSeverity of Illness IndexShock, CardiogenicConceptsMELD-Na scoreVA-ECMOMELD scoreMELD-XIReceiver operating characteristicMELD-NaCardiogenic shockSingle-center retrospective reviewVeno-arterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenation supportMultivariate Cox regression analysisVeno-arterial extracorporeal membrane oxygenation supportVA-ECMO initiationLeft ventricular assist device placementVentricular assist device placementMELD-XI scoreExtracorporeal membrane oxygenationMembrane oxygenation supportMarker of survivalCox regression analysisPredictive of survivalLong-term mortalityChronic liver diseaseAssociated with mortalityECMO initiation
2020
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Asher SR, Malzberg GW, Ong CS, Malapero RJ, Wang H, Shekar P, Kaneko T, Pelletier MP, Mallidi H, Heydarpour M, Shook DC, Shernan SK, Fox JA, Muehlschlegel JD, Xu X, Nguyen TB, Sundt TM, Body SC. Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality. Interdisciplinary CardioVascular And Thoracic Surgery 2020, 32: 9-19. PMID: 33313764, PMCID: PMC8600023, DOI: 10.1093/icvts/ivaa230.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationAortic valve replacementModerate mitral regurgitationMitral regurgitationMR severityPostoperative mortalityPreoperative transthoracicValve replacementEchocardiographic assessmentLong-term postoperative mortalityAortic valve replacement surgerySeverity of MRCoronary artery bypassLong-term mortalityValve replacement surgeryInduction of anesthesiaIschemic heart diseaseAortic valve diseaseProportional hazards regressionMitral valve repairPrediction of mortalityFunctional mitral regurgitation severityMitral regurgitation severityIntraoperative reassessmentArtery bypassAcute kidney injury in renal transplant recipients undergoing cardiac surgery
Hundemer G, Srivastava A, Jacob K, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel K, Hirji S, Pelletier M, Safa K, Kulvichit W, Kellum J, Riella L, Leaf D. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2020, 36: 185-196. PMID: 32892219, PMCID: PMC7771983, DOI: 10.1093/ndt/gfaa063.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsAcute kidney injuryNon-RTRsCardiac surgeryCalcineurin inhibitorsRisk factorsTransplant recipientsKidney injuryType of cardiac surgeryKidney diseaseRates of acute kidney injuryRisk of acute kidney injuryDeceased donorsGlobal Outcomes criteriaLiving donorsRetrospective cohort studyAssociated with higher ratesChronic kidney diseaseTrough levelsClinical characteristicsAcademic medical centerCohort studySurgeryHigh riskMedical CenterSex-based differences in mitral valve Re-operation after mitral valve repair: Truth or myth?
Hirji S, Guetter C, Trager L, Yazdchi F, Landino S, Lee J, Anastasopulos A, Percy E, McGurk S, Pelletier M, Aranki S, Shekar P, Kaneko T. Sex-based differences in mitral valve Re-operation after mitral valve repair: Truth or myth? The American Journal Of Surgery 2020, 220: 1344-1350. PMID: 32788080, DOI: 10.1016/j.amjsurg.2020.06.069.Peer-Reviewed Original ResearchConceptsRe-operation riskRe-operationMV repairRheumatic diseasesFemale sexMitral valve re-operationMV repair durabilityMedian follow-upMitral valve repairAssociated with rheumatic diseasesSTS risk scoreOperative mortalityValve repairPreoperative profilesAdult patientsFollow-upDisease progressionSex-based differencesRepair durabilityRepair failureWomenRepairRiskLongitudinal analysisSexNational Outcomes of Surgical Embolectomy for Acute Pulmonary Embolism
Percy E, Shah R, Hirji S, Tartarini R, Yazdchi F, Harloff M, Kaneko T, Pelletier M. National Outcomes of Surgical Embolectomy for Acute Pulmonary Embolism. The Annals Of Thoracic Surgery 2020, 110: 441-447. PMID: 32199827, DOI: 10.1016/j.athoracsur.2020.02.024.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultEmbolectomyFemaleHumansMaleMiddle AgedPulmonary EmbolismRetrospective StudiesTreatment OutcomeUnited StatesYoung AdultConceptsAcute pulmonary embolismCatheter-directed therapySurgical embolectomyPulmonary embolismSystemic thrombolysisContemporary outcomes of patientsTreated with systemic thrombolysisAssociated with increased odds of mortalityHigher in-hospital mortalityOutcomes of patientsIn-hospital mortalityAssociated with increased oddsOdds of mortalityReal-world studyHigh-risk conditionsNational Inpatient SampleSurgical groupIntracranial hemorrhageSaddle embolusBlood transfusionMultidisciplinary treatmentEmbolectomy patientsAtrial fibrillationSurgical patientsContemporary outcomesOutcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty
Hirji S, Yazdchi F, Kiehm S, Landino S, McGurk S, Muehlschlegel J, Singh S, Mallidi H, Pelletier M, Aranki S, Shekar P, Kaneko T. Outcomes After Tricuspid Valve Repair With Ring Versus Suture Bicuspidization Annuloplasty. The Annals Of Thoracic Surgery 2020, 110: 821-828. PMID: 32001230, DOI: 10.1016/j.athoracsur.2019.12.023.Peer-Reviewed Original ResearchConceptsTricuspid valve repairEvent-free survivalTricuspid valve reoperationValve repairTR recurrenceValve reoperationTricuspid regurgitationConcomitant aortic valveCoronary artery bypass grafting proceduresFunctional tricuspid regurgitationTricuspid valve insufficiencyTricuspid valve replacementDevice placement procedureConventional surgical techniquesIn-hospital outcomesBypass grafting proceduresBicuspidization techniqueAortic proceduresRing annuloplastyMidterm outcomesValve insufficiencyValve replacementEchocardiographic profileHeart transplantationMitral valveThirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery
Hirji SA, Percy ED, Zogg CK, Vaduganathan M, Kiehm S, Pelletier M, Kaneko T. Thirty-Day Nonindex Readmissions and Clinical Outcomes After Cardiac Surgery. The Annals Of Thoracic Surgery 2020, 110: 484-491. PMID: 31972128, PMCID: PMC7382395, DOI: 10.1016/j.athoracsur.2019.11.042.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementNonindex readmissionsCardiac surgeryNonindex hospitalNonindex hospital readmissionsCoronary artery bypassNational Readmission DatabaseAortic valve replacementCardiac surgery patientsMajor cardiac surgeryPatient risk profileHigh-volume centersUS adult patientsRegionalization of careFragmentation of careComorbidity burdenHospital mortalityIndex readmissionArtery bypassInitial hospitalizationAdult patientsSurgery patientsValve replacementHospital readmissionIndependent predictorsLong-Term Outcomes of Right Minithoracotomy Versus Hemisternotomy for Mitral Valve Repair
Percy E, Hirji S, Yazdchi F, McGurk S, Kiehm S, Cook R, Kaneko T, Shekar P, Pelletier M. Long-Term Outcomes of Right Minithoracotomy Versus Hemisternotomy for Mitral Valve Repair. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2020, 15: 74-80. PMID: 31957524, DOI: 10.1177/1556984519891966.Peer-Reviewed Original ResearchConceptsMitral valve repairMinimally invasive mitral valve repairRight minithoracotomyValve repairLong-term survivalRT groupMitral reoperationMitral repairHS groupIsolated mitral repairCross-clamp timeFollow-up timeShort-term outcomesCox proportional hazards modelsLong-term outcomesRisk-adjusted survivalProportional hazards modelLower hemisternotomyOperative mortalityPatient yearsPostoperative complicationsLonger bypassHemisternotomyExcellent survivalMean age
2019
Myocardial preservation methods in isolated minimal invasive mitral valve surgery: Society of Thoracic Surgeons (STS) database outcomes
Loberman D, Pelletier M, Yazdchi F, Aranki S, Preisler Y, Mohr R, Ziv‐Baran T. Myocardial preservation methods in isolated minimal invasive mitral valve surgery: Society of Thoracic Surgeons (STS) database outcomes. Journal Of Cardiac Surgery 2019, 35: 163-173. PMID: 31733079, DOI: 10.1111/jocs.14351.Peer-Reviewed Original ResearchConceptsMinimally invasive mitral valve surgerySociety of Thoracic SurgeonsMitral valve surgeryInvasive mitral valve surgeryAssociated with increased riskValve surgeryEjection fractionThoracic surgeonsCrystalloid solutionRetrospective analysis of patientsTechniques of myocardial preservationSTS databaseMyocardial preservation methodsLength of ICU stayPostoperative ejection fractionAnalysis of patientsShort-term outcomesAssociated with mortalityPleural effusionICU stayRetrospective analysisTerm outcomesCPK-MBCardioplegia techniqueMultivariate analysisCardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries
Shah R, Hirji S, Percy E, Landino S, Yazdchi F, Bellavia A, Pelletier M, Shekar P, Kaneko T. Cardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries. The Annals Of Thoracic Surgery 2019, 109: 1194-1201. PMID: 31479643, DOI: 10.1016/j.athoracsur.2019.07.041.Peer-Reviewed Original ResearchConceptsOpioid use disorderCardiac surgeryIncreased risk of postoperative morbidityImpact of opioid use disorderRisk of postoperative morbidityOpioid epidemicAssociated with prolonged hospitalizationRisk factorsUse disorderOpioid use disorder statusCoronary artery bypass graftingNon-opioid usersPreoperative risk factorsCardiac surgery patientsPatient's preoperative risk factorsAcute kidney injuryArtery bypass graftingCardiac surgery outcomesIn-hospital mortalityCurrent opioid epidemicLonger hospital lengthImprove overall outcomesHigher hospital costsNational Inpatient SampleValve repairSignificance of Interstitial Lung Disease on Outcomes Following Cardiac Surgery
Hirji S, Ramirez-Del Val F, Ejiofor J, Lee J, Norman A, McGurk S, Pelletier M, Aranki S, Rawn J, Shekar P, Hunninghake G, Kaneko T. Significance of Interstitial Lung Disease on Outcomes Following Cardiac Surgery. The American Journal Of Cardiology 2019, 124: 1133-1139. PMID: 31405546, DOI: 10.1016/j.amjcard.2019.06.031.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseInterstitial lung disease patientsIdiopathic pulmonary fibrosisLong-term survivalLonger intensive care unitCardiac surgeryNon-ILD patientsIntensive care unitReintubation rateAssociated with shorter long-term survivalLung diseaseComparison cohortSeverity of interstitial lung diseaseShorter long-term survivalCare unitKaplan-Meier estimates of survivalIdiopathic pulmonary fibrosis cohortsRisk factorsInterstitial lung disease diagnosisSurvival analysisAcute pulmonary exacerbationsIncreased operative mortalityMedian follow-upCardiac surgery patientsRisk-adjusted survival analysisCharacterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement
Kaneko T, Hirji S, Percy E, Aranki S, McGurk S, Body S, Heydarpour M, Mallidi H, Singh S, Pelletier M, Rawn J, Shekar P. Characterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement. The Annals Of Thoracic Surgery 2019, 108: 1761-1767. PMID: 31207248, DOI: 10.1016/j.athoracsur.2019.04.080.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCalcinosisEchocardiography, TransesophagealFemaleFollow-Up StudiesHeart Valve DiseasesHeart Valve Prosthesis ImplantationHospital MortalityHumansIncidenceIntraoperative ComplicationsMaleMiddle AgedMitral ValvePostoperative ComplicationsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival RateUnited StatesConceptsMitral annular calcificationAssociated with increased operative mortalityPresence of mitral annular calcificationMV replacementOperative mortalityAnnular calcificationSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseMAC patientsAssociated with increased risk of acute kidney injuryAdult Cardiac Surgery DatabaseRisk of acute kidney injuryMitral valve (MVConcomitant tricuspid proceduresNon-MAC patientsObserved operative mortalityCardiac Surgery DatabaseMitral valve replacementAssociated with increased riskAdverse postoperative outcomesAcute kidney injuryIn-hospital complicationsTricuspid proceduresReoperation rateSurgery DatabaseValve replacementChronic opioid use after coronary bypass surgery
Hirji S, Landino S, Cote C, Lee J, Orhurhu V, Shah R, McGurk S, Kaneko T, Shekar P, Pelletier M. Chronic opioid use after coronary bypass surgery. Journal Of Cardiac Surgery 2019, 34: 67-73. PMID: 30625257, DOI: 10.1111/jocs.13981.Peer-Reviewed Original ResearchConceptsOpioid-exposed patientsCoronary artery bypass graftingOpioid naive patientsChronic opioid useChronic opioid dependenceOpioid dependencePrescribing patternsOpioid useIsolated coronary artery bypass graftingAlternative pain management strategiesTotal dose >Opioid prescribing patternsPain management strategiesArtery bypass graftingCoronary bypass surgeryInvasive surgical proceduresOpioid usageBypass surgeryPain managementBypass graftingSurgical proceduresOpioidOpioid epidemicPatientsMedication usage
2018
Mechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Aged 50 Years and Younger
Hirji S, Kolkailah A, Ramirez-Del Val F, Lee J, McGurk S, Pelletier M, Singh S, Mallidi H, Aranki S, Shekar P, Kaneko T. Mechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Aged 50 Years and Younger. The Annals Of Thoracic Surgery 2018, 106: 1113-1120. PMID: 29966596, DOI: 10.1016/j.athoracsur.2018.05.073.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAortic Valve StenosisBioprosthesisCohort StudiesDatabases, FactualFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansKaplan-Meier EstimateMaleMiddle AgedPostoperative ComplicationsPostoperative HemorrhagePrognosisPropensity ScoreProportional Hazards ModelsProsthesis DesignReoperationRetrospective StudiesRisk AssessmentSurvival AnalysisConceptsMechanical aortic valve replacementBioprosthetic AVRAortic valve replacementLong-term survivalOperative mortalityValve replacementRedo-AVRConcomitant coronary artery bypass graftingLong-term survival differenceEnd pointsIncreased risk of reoperationBioprosthetic aortic valve replacementCoronary artery bypass graftingMitral valve proceduresMedian observation timeSecondary end pointsMechanical aortic valve replacement patientsPrimary end pointRisk of reoperationArtery bypass graftingStudy evaluated outcomesValve proceduresBleeding incidenceYounger patientsSurvival differencesMinimally invasive versus full sternotomy aortic valve replacement in low-risk patients: Which will stand against transcatheter aortic valve replacement?
Hirji S, Funamoto M, Lee J, Ramirez Del Val F, Kolkailah A, McGurk S, Pelletier M, Aranki S, Shekar P, Kaneko T. Minimally invasive versus full sternotomy aortic valve replacement in low-risk patients: Which will stand against transcatheter aortic valve replacement? Surgery 2018, 164: 282-287. PMID: 29699805, DOI: 10.1016/j.surg.2018.02.018.Peer-Reviewed Original ResearchConceptsMinimally invasive aortic valve replacementAortic valve replacement patientsAortic valve replacementLow-risk patientsMinimally invasive aortic valve replacement patientsValve replacement patientsSternotomy aortic valve replacementIntensive care unitTranscatheter aortic valve replacementValve replacementCongestive heart failureCare unitReoperation rateHeart failureElective isolated aortic valve replacementHospital lengthReplacement patientsAortic valve replacement resultsMedian intensive care unitShorter intensive care unitPredictors of decreased survivalShorter median intensive care unitValve replacement resultsAssociated with improved resultsPredicted risk of mortality
2017
Impact of flow, gradient, and left ventricular function on outcomes after transcatheter aortic valve replacement
Carreras E, Kaneko T, Val F, Pelletier M, Sobieszczyk P, Bhatt D, Shah P. Impact of flow, gradient, and left ventricular function on outcomes after transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2017, 91: 798-805. PMID: 28988432, PMCID: PMC5849510, DOI: 10.1002/ccd.27347.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBostonFemaleHeart FailureHospital MortalityHumansLength of StayMaleRecovery of FunctionRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsTranscatheter aortic valve replacementAortic valve replacementStroke volume indexHeart failureReduced LVEFValve replacementIncreased mortalityOutcomes similar to patientsTranscatheter aortic valve replacement patientsPredictor of 1-year mortalityAssociated with increased mortalityOutcomes of patientsLeft ventricular functionSimilar to patientsReduced EFVentricular functionLVEFClinical factorsWomen's HospitalVolume indexPatientsAssociated with increasesMortalityTranscatheterOutcomes
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