2024
The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
Shah A, Ding Y, Walji D, Rabinovich G, Pelletier M, El-Diasty M. The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review. Biomarkers 2024, 29: 485-493. PMID: 39422445, DOI: 10.1080/1354750x.2024.2415073.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAtrial FibrillationBiomarkersBlood ProteinsCardiac Surgical ProceduresGalectin 3GalectinsHumansPostoperative ComplicationsPrognosisConceptsAssociated with acute kidney injuryPostoperative atrial fibrillationGal-3 levelsLeft ventricular reverse remodelingCardiac surgeryAdverse outcomesGal-3Clinical risk prediction scorePreoperative plasma levelsVentricular reverse remodelingEuroSCORE II modelPlasma Gal-3 levelsPostoperative adverse outcomesAcute kidney injuryGalectin-3Group of patientsPredicting adverse outcomesRisk prediction scorePostoperative morbidityReverse remodelingPostoperative mortalityElectronic database searchPrognostic utilityAdult patientsKidney injury
2020
Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement
Sheikh M, Deo S, Riaz H, Raza S, Altarabsheh S, Wilson B, Elgudin Y, Cmolik B, Pelletier M, Markowitz A. Safety‐net hospitals versus non‐safety centers and clinical outcomes after trans‐catheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2020, 97: e425-e430. PMID: 32681697, DOI: 10.1002/ccd.29123.Peer-Reviewed Original ResearchConceptsValve replacementNational in-patient sampleLength of post-operative stayPropensity-matched cohort of patientsTrans-catheter aortic valve replacementPost-operative stayAortic valve replacementClinical co-variatesCohort of patientsAcute kidney injuryPropensity-matched cohortPost-procedural mortalityPost-procedural outcomesClinical outcomesKidney injurySecondary outcomesIn-patient samplePatientsLow-income patientsSafety-net hospitalHospitalOutcomesSafety-netIncome patientsNon-safety net hospitalsThe impact of hospital size on national trends and outcomes in isolated open proximal aortic surgery
Hirji S, Shah R, Aranki S, McGurk S, Singh S, Mallidi H, Pelletier M, Shekar P, Kaneko T. The impact of hospital size on national trends and outcomes in isolated open proximal aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 1269-1278.e9. PMID: 32713639, DOI: 10.1016/j.jtcvs.2020.03.180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAortic AneurysmAortic DiseasesAortic DissectionAortic RuptureBenchmarkingBlood Vessel Prosthesis ImplantationDatabases, FactualFemaleHealth Facility SizeHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHumansLength of StayMaleMiddle AgedPostoperative ComplicationsThoracic Surgical ProceduresUnited StatesConceptsProximal aortic surgeryAortic surgeryImpact of hospital sizeHospital sizeIn-hospital cardiac complicationsLarge hospitalsProximal aortic operationsRe-do proceduresHospital costsPatients aged >Propensity-score matching analysisOverall in-hospital mortalityIn-hospital mortalityIn-hospital outcomesShorter length of stayLower hospital costsPropensity-score matchingIn-hospital mortality trendsBenchmark hospital performanceLength of stayNational Inpatient SampleConcomitant valvularAortic operationsOperative mortalityCardiac complicationsQuantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation
Hirji SA, Zogg CK, Vaduganathan M, Kiehm S, Percy ED, Yazdchi F, Pelletier M, Shah PB, Bhatt DL, O'Gara P, Kaneko T. Quantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 128: 113-119. PMID: 32650903, DOI: 10.1016/j.amjcard.2020.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCenters for Medicare and Medicaid Services, U.S.ComorbidityContinuity of Patient CareCoronary AngiographyDiabetes MellitusFemaleHospital CostsHospital MortalityHospitalsHumansHypertensionLength of StayLung DiseasesMaleMultivariate AnalysisPacemaker, ArtificialPatient ReadmissionPericardiocentesisPostoperative ComplicationsProsthesis ImplantationStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsNonindex hospitalNonindex readmissionsCare fragmentationTranscatheter aortic valve implantation outcomesTranscatheter aortic valve implantationHigher co-morbidity burdenNational Readmission DatabaseAortic valve implantationCo-morbidity burdenTotal hospital costsMajor cardiac proceduresUS adult patientsFuture health policyValue of careIndex readmissionTAVI patientsCause mortalityIndex hospitalNoncardiac causesAdult patientsPatient characteristicsReadmission ratesValve implantationReadmission lengthCardiac proceduresTranscatheter vs surgical aortic valve replacement in patients with interstitial lung disease
Hirji S, Cote C, Lee J, Kiehm S, McGurk S, Pelletier M, Aranki S, Shekar P, Shah P, Kaneko T. Transcatheter vs surgical aortic valve replacement in patients with interstitial lung disease. Journal Of Cardiac Surgery 2020, 35: 571-579. PMID: 31981435, DOI: 10.1111/jocs.14421.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementInterstitial lung diseaseAortic valve replacementTranscatheter aortic valve replacement patientsIntensive care unitSurgical aortic valve replacement patientsInterstitial lung disease patientsShorter ventilation timeValve replacementOperative mortalityAortic stenosisVentilation timeLung diseaseRisk of postoperative pulmonary complicationsIsolated surgical aortic valve replacementDiagnosis of interstitial lung diseaseAssociated with significantly shorter hospitalRate of postoperative strokeIntensive care unit admissionPostoperative pulmonary complicationsSignificantly shorter hospitalSevere aortic stenosisPermanent pacemaker implantationSymptomatic aortic stenosis
2019
Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Cochrane Database Of Systematic Reviews 2019, 12: cd013319. PMID: 31860123, PMCID: PMC6984621, DOI: 10.1002/14651858.cd013319.pub2.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHumansPostoperative ComplicationsRandomized Controlled Trials as TopicRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementLength of hospital stayLow surgical riskAortic valve replacementTranscatheter aortic valve implantationAcute kidney injuryRisk of PPM implantationRisk of atrial fibrillationSurgical riskAortic valve stenosisRandomised controlled trialsValve replacementAortic valve implantationAtrial fibrillationCardiac deathCertainty of evidenceMyocardial infarctionPPM implantationPermanent pacemakerValve implantationAssociated with shorter lengths of hospital stayNew-onset atrial fibrillationRisk ratioLong-term follow-up dataShorter length of hospital stayCardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries
Shah R, Hirji S, Percy E, Landino S, Yazdchi F, Bellavia A, Pelletier M, Shekar P, Kaneko T. Cardiac Surgery in Patients With Opioid Use Disorder: An Analysis of 1.7 Million Surgeries. The Annals Of Thoracic Surgery 2019, 109: 1194-1201. PMID: 31479643, DOI: 10.1016/j.athoracsur.2019.07.041.Peer-Reviewed Original ResearchConceptsOpioid use disorderCardiac surgeryIncreased risk of postoperative morbidityImpact of opioid use disorderRisk of postoperative morbidityOpioid epidemicAssociated with prolonged hospitalizationRisk factorsUse disorderOpioid use disorder statusCoronary artery bypass graftingNon-opioid usersPreoperative risk factorsCardiac surgery patientsPatient's preoperative risk factorsAcute kidney injuryArtery bypass graftingCardiac surgery outcomesIn-hospital mortalityCurrent opioid epidemicLonger hospital lengthImprove overall outcomesHigher hospital costsNational Inpatient SampleValve repairDebunking the July Effect in Cardiac Surgery: A National Analysis of More Than 470,000 Procedures
Shah RM, Hirji SA, Kiehm S, Goel S, Yazdchi F, Bellavia A, Zogg CK, Pelletier MP, Shekar P, Kaneko T. Debunking the July Effect in Cardiac Surgery: A National Analysis of More Than 470,000 Procedures. The Annals Of Thoracic Surgery 2019, 108: 929-934. PMID: 31353035, DOI: 10.1016/j.athoracsur.2019.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedCardiac Surgical ProceduresClinical CompetenceCohort StudiesDatabases, FactualEducation, Medical, GraduateFemaleHospital MortalityHospitals, TeachingHumansInpatientsInternship and ResidencyMaleMedical Staff, HospitalMiddle AgedPostoperative ComplicationsQuality of Health CareRisk AdjustmentSeasonsUnited StatesConceptsAortic valve replacementCardiac surgeryJuly effectHospital mortalityPatient outcomesTeaching hospitalMajor cardiac surgery proceduresSurgical aortic valve replacementCoronary artery bypassCardiac surgery proceduresNational Inpatient SampleRisk-adjusted mortalityMitral valve repairCardiac surgery outcomesHospital complicationsArtery bypassMV surgeryNoncardiac surgeryValve replacementAdjusted mortalityValve repairSurgery outcomesInpatient SampleWorse outcomesHospital support systemsSignificance of Interstitial Lung Disease on Outcomes Following Cardiac Surgery
Hirji S, Ramirez-Del Val F, Ejiofor J, Lee J, Norman A, McGurk S, Pelletier M, Aranki S, Rawn J, Shekar P, Hunninghake G, Kaneko T. Significance of Interstitial Lung Disease on Outcomes Following Cardiac Surgery. The American Journal Of Cardiology 2019, 124: 1133-1139. PMID: 31405546, DOI: 10.1016/j.amjcard.2019.06.031.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseInterstitial lung disease patientsIdiopathic pulmonary fibrosisLong-term survivalLonger intensive care unitCardiac surgeryNon-ILD patientsIntensive care unitReintubation rateAssociated with shorter long-term survivalLung diseaseComparison cohortSeverity of interstitial lung diseaseShorter long-term survivalCare unitKaplan-Meier estimates of survivalIdiopathic pulmonary fibrosis cohortsRisk factorsInterstitial lung disease diagnosisSurvival analysisAcute pulmonary exacerbationsIncreased operative mortalityMedian follow-upCardiac surgery patientsRisk-adjusted survival analysisCharacterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement
Kaneko T, Hirji S, Percy E, Aranki S, McGurk S, Body S, Heydarpour M, Mallidi H, Singh S, Pelletier M, Rawn J, Shekar P. Characterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement. The Annals Of Thoracic Surgery 2019, 108: 1761-1767. PMID: 31207248, DOI: 10.1016/j.athoracsur.2019.04.080.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCalcinosisEchocardiography, TransesophagealFemaleFollow-Up StudiesHeart Valve DiseasesHeart Valve Prosthesis ImplantationHospital MortalityHumansIncidenceIntraoperative ComplicationsMaleMiddle AgedMitral ValvePostoperative ComplicationsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival RateUnited StatesConceptsMitral annular calcificationAssociated with increased operative mortalityPresence of mitral annular calcificationMV replacementOperative mortalityAnnular calcificationSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseMAC patientsAssociated with increased risk of acute kidney injuryAdult Cardiac Surgery DatabaseRisk of acute kidney injuryMitral valve (MVConcomitant tricuspid proceduresNon-MAC patientsObserved operative mortalityCardiac Surgery DatabaseMitral valve replacementAssociated with increased riskAdverse postoperative outcomesAcute kidney injuryIn-hospital complicationsTricuspid proceduresReoperation rateSurgery DatabaseValve replacement
2018
Mechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Aged 50 Years and Younger
Hirji S, Kolkailah A, Ramirez-Del Val F, Lee J, McGurk S, Pelletier M, Singh S, Mallidi H, Aranki S, Shekar P, Kaneko T. Mechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Aged 50 Years and Younger. The Annals Of Thoracic Surgery 2018, 106: 1113-1120. PMID: 29966596, DOI: 10.1016/j.athoracsur.2018.05.073.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAortic Valve StenosisBioprosthesisCohort StudiesDatabases, FactualFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansKaplan-Meier EstimateMaleMiddle AgedPostoperative ComplicationsPostoperative HemorrhagePrognosisPropensity ScoreProportional Hazards ModelsProsthesis DesignReoperationRetrospective StudiesRisk AssessmentSurvival AnalysisConceptsMechanical aortic valve replacementBioprosthetic AVRAortic valve replacementLong-term survivalOperative mortalityValve replacementRedo-AVRConcomitant coronary artery bypass graftingLong-term survival differenceEnd pointsIncreased risk of reoperationBioprosthetic aortic valve replacementCoronary artery bypass graftingMitral valve proceduresMedian observation timeSecondary end pointsMechanical aortic valve replacement patientsPrimary end pointRisk of reoperationArtery bypass graftingStudy evaluated outcomesValve proceduresBleeding incidenceYounger patientsSurvival differencesMinimally invasive versus full sternotomy aortic valve replacement in low-risk patients: Which will stand against transcatheter aortic valve replacement?
Hirji S, Funamoto M, Lee J, Ramirez Del Val F, Kolkailah A, McGurk S, Pelletier M, Aranki S, Shekar P, Kaneko T. Minimally invasive versus full sternotomy aortic valve replacement in low-risk patients: Which will stand against transcatheter aortic valve replacement? Surgery 2018, 164: 282-287. PMID: 29699805, DOI: 10.1016/j.surg.2018.02.018.Peer-Reviewed Original ResearchConceptsMinimally invasive aortic valve replacementAortic valve replacement patientsAortic valve replacementLow-risk patientsMinimally invasive aortic valve replacement patientsValve replacement patientsSternotomy aortic valve replacementIntensive care unitTranscatheter aortic valve replacementValve replacementCongestive heart failureCare unitReoperation rateHeart failureElective isolated aortic valve replacementHospital lengthReplacement patientsAortic valve replacement resultsMedian intensive care unitShorter intensive care unitPredictors of decreased survivalShorter median intensive care unitValve replacement resultsAssociated with improved resultsPredicted risk of mortality
2017
Isolated hyperammonemic encephalopathy in heart transplantation
Madathil R, Gilstrap L, Pelletier M, Mehra M. Isolated hyperammonemic encephalopathy in heart transplantation. The Journal Of Heart And Lung Transplantation 2017, 37: 427-429. PMID: 29275142, DOI: 10.1016/j.healun.2017.12.001.Peer-Reviewed Original ResearchAdultBrain Diseases, MetabolicHeart TransplantationHumansHyperammonemiaMalePostoperative ComplicationsThe Perceval Sutureless Aortic Valve
Powell R, Pelletier M, Chu M, Bouchard D, Melvin K, Adams C. The Perceval Sutureless Aortic Valve. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2017, 12: 155-173. PMID: 28570342, DOI: 10.1097/imi.0000000000000372.Peer-Reviewed Original ResearchConceptsStatistically significant reductionStented prosthesesAortic valvePooled analysisLowest postoperative platelet countSutureless aortic valve bioprosthesisRate of permanent pacemaker implantationSurgical aortic valve replacementConcomitant valvular proceduresMinimally invasive casesPerceval aortic valveCardiopulmonary bypass timePostoperative platelet countBicuspid aortic valveSignificant reductionThirty-day mortalityAortic valve replacementAortic cross-clampingOff-label procedurePermanent pacemaker implantationTranscatheter aortic valve implantationAortic valve bioprosthesisCochrane Library databasesValve-in-valveAortic valve implantation
2015
Quality of Care for Transcatheter Aortic Valve Implantation: Development of Canadian Cardiovascular Society Quality Indicators
Asgar A, Lauck S, Ko D, Alqoofi F, Cohen E, Forsey A, Lambert L, Oakes G, Pelletier M, Webb J, Group C. Quality of Care for Transcatheter Aortic Valve Implantation: Development of Canadian Cardiovascular Society Quality Indicators. Canadian Journal Of Cardiology 2015, 32: 1038.e1-1038.e4. PMID: 26948037, DOI: 10.1016/j.cjca.2015.11.008.Peer-Reviewed Original ResearchMeSH KeywordsAortic Valve StenosisCanadaHealth Services AccessibilityHospital MortalityHumansOutcome and Process Assessment, Health CarePatient Care TeamPatient ReadmissionPatient-Centered CarePostoperative ComplicationsQuality Indicators, Health CareQuality of Health CareQuality of LifeStrokeTime-to-TreatmentTranscatheter Aortic Valve ReplacementWaiting ListsConceptsQuality of careQuality indicatorsCanadian Cardiovascular SocietyEvaluation of quality of careMeasure quality of careTranscatheter aortic valve implantationWorking GroupNational quality assuranceOutcome indicatorsClinical careQuality reportingCareMeasure qualityProgram coordinatorsQuality InitiativeGovernment agency representativesAgency representativesConsensus agreementCardiovascular SocietyAortic valve implantationNational strategyAortic stenosisValve implantationCanadianMultiple stakeholders
2007
Right Atrial Mass After Primary Repair of an Atrial Septal Defect: Thrombus Masquerading as a Myxoma
Sheikh A, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier M. Right Atrial Mass After Primary Repair of an Atrial Septal Defect: Thrombus Masquerading as a Myxoma. The Annals Of Thoracic Surgery 2007, 84: 1742-1744. PMID: 17954102, DOI: 10.1016/j.athoracsur.2007.05.065.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiagnosis, DifferentialEchocardiographyFemaleHeart AtriaHeart NeoplasmsHeart Septal Defects, AtrialHumansMagnetic Resonance ImagingMyxomaPostoperative ComplicationsThrombosisConceptsAtrial septal defectRight atrial massSeptal defectAtrial massPrimary repairMagnetic resonance imaging 3 yearsRepair of atrial septal defectAtrial septal defect repairSeptal defect repairAtrial thrombusSurgical repairCongenital anomaliesThromboembolic complicationsEmbolic eventsClinical managementOrganized thrombusThrombusThrombus formationMyxomaComplicationsRepairDefect repairEchocardiographyEffect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease
Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein M, Robbins R, Pelletier M. Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease. American Journal Of Transplantation 2007, 7: 1733-1742. PMID: 17532751, DOI: 10.1111/j.1600-6143.2007.01858.x.Peer-Reviewed Original ResearchConceptsObliterative airway diseaseTreatment groupsAirway diseaseSystemic side effectsCellular immune activationOrthotopic tracheal transplantationGraft infiltrationCellular rejectionCellular immunosuppressionHumoral rejectionAllograft rejectionElevated BUNImmune activationTacrolimusAerosol inhalationMononuclear infiltrationSide effectsPOD 8Tracheal transplantationAirway graftsPO animalsHistology of graftsGraftTreatmentPods
2006
A randomized comparison of intraoperative indocyanine green angiography and transit-time flow measurement to detect technical errors in coronary bypass grafts
Desai N, Miwa S, Kodama D, Koyama T, Cohen G, Pelletier M, Cohen E, Christakis G, Goldman B, Fremes S. A randomized comparison of intraoperative indocyanine green angiography and transit-time flow measurement to detect technical errors in coronary bypass grafts. Journal Of Thoracic And Cardiovascular Surgery 2006, 132: 585-594. PMID: 16935114, DOI: 10.1016/j.jtcvs.2005.09.061.Peer-Reviewed Original ResearchConceptsIndocyanine green angiographyTransit-time flow measurementX-ray angiographyBypass graftingDiagnostic accuracyIsolated coronary artery bypass graftingIntraoperative indocyanine green angiographyUltrasound flow measurementsCoronary artery bypass graftingPostoperative day 4Artery bypass graftingCoronary bypass graftingGraft angiographyPostoperative angiographyBypass graft failureGraft failureGraft occlusionRandomized comparisonAngiographyPerianastomotic areaDetect technical errorsIndocyanineDay 4StenosisPatients
2002
Alternative approach for use of a left ventricular assist device with a thrombosed prosthetic valve
Pelletier M, Chang C, Vagelos R, Robbins R. Alternative approach for use of a left ventricular assist device with a thrombosed prosthetic valve. The Journal Of Heart And Lung Transplantation 2002, 21: 402-404. PMID: 11897531, DOI: 10.1016/s1053-2498(01)00354-0.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceVentricular assist deviceIncreased risk of thrombosisAortic outflow tractBovine pericardial patchTreating similar patientsRisk of thrombosisThrombosed prosthetic valveMechanical aortic valveProsthetic heart valvesOutflow tractPericardial patchAortic valveProsthetic valvesIncreased riskAssist devicePatientsHeart valvesParaplegia After Routine Cardiac Surgery: A Rare Complication
Pelletier M, Al‐Khaldi A, Berry G, Morin J. Paraplegia After Routine Cardiac Surgery: A Rare Complication. Journal Of Cardiac Surgery 2002, 17: 410-412. PMID: 12630541, DOI: 10.1111/j.1540-8191.2001.tb01170.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisCardiopulmonary BypassFatal OutcomeHumansIschemiaMaleMitral Valve InsufficiencyParaplegiaPostoperative ComplicationsSpinal CordConceptsCase of spinal cord infarctionRoutine cardiac surgerySpinal cord infarctionClinical paraplegiaCardiac surgeryCord infarctionRare complicationPeripheral embolismCardiopulmonary bypassCardiac proceduresPrimary etiologyEtiologyParaplegiaEmbolizationSurgeryComplicationsCardiopulmonaryPatientsBypassInfarctionCases
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