2024
Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation
Hungate J, Onders R, Diasty M, Abu-Omar Y, Arora R, Baeza C, Elgudin Y, Gray K, Markowitz A, Pelletier M, Ribeiro I, Vega P, Rushing G, Sabik J. Randomized study of temporary diaphragm pacing for enhanced recovery after surgery in cardiac surgery patients at risk of prolonged mechanical ventilation. JTCVS Open 2024, 22: 76-84. PMID: 39780786, PMCID: PMC11704535, DOI: 10.1016/j.xjon.2024.09.031.Peer-Reviewed Original ResearchProlonged mechanical ventilationStandard of care groupRisk of prolonged mechanical ventilationMechanical ventilationCardiac surgeryDiaphragmatic pacingDiaphragm pacingTreatment groupsRandomized trialsHistory of chronic obstructive pulmonary diseaseLeft ventricular ejection fractionIntra-aortic balloon pumpDecrease mechanical ventilationCardiac surgery patientsVentricular ejection fractionHigh-risk patientsMulticenter randomized trialCare groupEnhanced recoveryChronic obstructive pulmonary diseaseRelative risk reductionIntensive care unitStandard of carePredictive enrichment strategiesObstructive pulmonary disease
2007
Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease
Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein M, Robbins R, Pelletier M. Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease. American Journal Of Transplantation 2007, 7: 1733-1742. PMID: 17532751, DOI: 10.1111/j.1600-6143.2007.01858.x.Peer-Reviewed Original ResearchConceptsObliterative airway diseaseTreatment groupsAirway diseaseSystemic side effectsCellular immune activationOrthotopic tracheal transplantationGraft infiltrationCellular rejectionCellular immunosuppressionHumoral rejectionAllograft rejectionElevated BUNImmune activationTacrolimusAerosol inhalationMononuclear infiltrationSide effectsPOD 8Tracheal transplantationAirway graftsPO animalsHistology of graftsGraftTreatmentPods
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