Research & Publications
Manuel L. Fontes, MD is Professor of Anesthesiology at the Yale University School of Medicine. He is the Vice Chair of Diversity, Equity, and Inclusion, the Division Chief for Cardiac Anesthesia and the Director of Clinical Research for the Department of Anesthesiology at Yale.
Dr. Fontes has been conducting research in the field of cardiovascular medicine as it applies to anesthesiology and critical care for nearly three decades. His recent research interest has greatly focused on hematology/inflammation and ischemic outcomes in the environment of open-heart surgery. As a junior faculty at Yale, he participated in a number of research pursuits addressing inflammatory responses during and after cardiopulmonary bypass. Specifically he addressed both humoral as well as cellular inflammatory responses in the context of cardiopulmonary bypass (CPB)- demonstrating significant associations between platelet activation and cardiac and cerebral events; monocyte activation and new-onset atrial fibrillation after surgery; and neutrophil activation and acute kidney injury (AKI). In 1999, he rejoined the Department of Anesthesiology at Weill-Cornell Medical College, NY and continued pursuing his research interests in this area and in clinical outcomes after cardiac surgery. Examples include multicenter perioperative studies investigating the effects of complement inhibition and clinical outcomes; C-reactive protein and atrial fibrillation; leukocytosis and atrial fibrillation.
Dr. Fontes was a member of the notable Multicenter Study on Perioperative Ischemia (McSPI) research group for nearly 20 years. His international perioperative research group investigated and published extensively on ischemic outcomes affecting the brain, the heart, kidneys, and mortality. In fact, several of his findings led to guidelines and “Standard of Care” practices; for example, perioperative beta blockers, early aspirin therapy after coronary bypass surgery, and discontinuation of aprotinin in cardiac surgery. In 2011, he joined the Department of Anesthesiology at Duke Medical Center, where he maintained an active research involvement both as an investigator and as the Director of the reputable CARE (Clinical Anesthesia Research Endeavor) Group- consisting of nearly 30 research staff members; over 50 active clinical protocols; and nearly five million research budget. He is particularly interested in investigating thrombotic events and factors that exacerbate morbidity and mortality in the setting of major vascular procedures. In 2015, Dr. Fontes rejoined the Department of Anesthesiology at Yale with responsibilities as Vice Chair of Diversity, Equity, and Inclusion, Chief of Cardiothoracic Anesthesiology, and Director of Clinical Research. He has been successful in rebuilding the clinical research infrastructure including recruitment of several internationally recognized clinical scolars. The Yale Department of Anesthesiology’s mission is to become a leader in vascular research and vascular aging. Dr. Fontes has authored and co-authored over 150 publications and has served as mentor to numerous medical students, residents, fellows, and faculty. His scholarly work and experience extend to military involvements (war veteran)- serving for 17 years and to an active international teaching and training for some 25 years as a member of various medical missions.
Education & Training
- MDUniversity of Massachusetts (1988)
- FellowshipNew York Hospital-Cornell Medical
- ResidencyThe New York Hospital
- InternshipMemorial Sloan Kettering Cancer Center
- Board CertificationAB of Anesthesiology, Anesthesiology (1994)
Honors & Recognition
|1999 President Citation Award 2004 Army Commendation Medal (1st Medal) 2004 National Defense Service Award (2nd Medal) 2004 Global War on Terrorism Expeditionary Metal (3rd Metal) 2004 Army Reserve Component Achievement Medal (4th Metal) 2004 Armed Forces Reserve Medal 2004 Army Service Ribbon 2005 NY Physician-of-year Award 2006 Physician of the Year Award 2006 The Ronald R Gold Medal Award 2007-13 America’s Top Anesthesiologists 2008-14 Who’s Who in America 2009-2014 Best Doctors in America 2013 Member, Association of University Anesthesiologists||Society of Critical Care Medicine; United States Army; New York State;|
|1993-Present Society of Cardiovascular Anesthesiology (SCA) 1993-Present American Society of Anesthesiology (ASA) 1994-2000 Society of Critical Care Medicine (SCCM) 1995-2000 American Society of Critical Care Anesthesiology 1995-1999 American Heart Association (AHA) 1996-1999 American Society of Echocardiography (ASE) 1995-2000 International Anesthesia Research Society (IARS) 2008-Present Association of Cardiovascular Anesthesiologist (ACA) 2010-Present Society of Academic Anesthesia Associations (SAAA) 2013-Present Association of University Anesthesiologists (AUA)|