2022
Native Planar Asymmetric Suspended Membrane for Single‐Molecule Investigations: Plasma Membrane on a Chip
Sundaram R, Bera M, Coleman J, Weerakkody J, Krishnakumar S, Ramakrishnan S. Native Planar Asymmetric Suspended Membrane for Single‐Molecule Investigations: Plasma Membrane on a Chip. Small 2022, 18: e2205567. PMID: 36328714, DOI: 10.1002/smll.202205567.Peer-Reviewed Original ResearchConceptsPlasma membraneProtein assembliesNative plasma membrane vesiclesTotal internal reflection fluorescence microscopySingle-molecule levelSingle-molecule investigationsCellular plasma membranePlasma membrane vesiclesSingle-molecule precisionReflection fluorescence microscopyKnowledge of lipidProtein complexesProtein architectureCell signalingMovement of moleculesProtein orientationLipid membranesBiological processesCellular membranesMembrane vesiclesMicroarray platformFluorescence investigationsLipid domainsFluorescence microscopyMembrane
2020
RETREG1/FAM134B mediated autophagosomal degradation of AMFR/GP78 and OPA1 —a dual organellar turnover mechanism
Mookherjee D, Das S, Mukherjee R, Bera M, Jana S, Chakrabarti S, Chakrabarti O. RETREG1/FAM134B mediated autophagosomal degradation of AMFR/GP78 and OPA1 —a dual organellar turnover mechanism. Autophagy 2020, 17: 1729-1752. PMID: 32559118, PMCID: PMC8354597, DOI: 10.1080/15548627.2020.1783118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagosomesCell Line, TumorChlorocebus aethiopsCOS CellsGene Knockdown TechniquesGTP PhosphohydrolasesHeLa CellsHumansIntracellular Signaling Peptides and ProteinsLysosomesMembrane ProteinsMicroscopy, ConfocalMicroscopy, Electron, TransmissionReal-Time Polymerase Chain ReactionReceptors, Autocrine Motility FactorConceptsInner mitochondrial membraneRETREG1/FAM134BEndoplasmic reticulumMitochondrial membraneFluorescent proteinAutophagosomal degradationOuter mitochondrial membrane proteinMahogunin Ring Finger-1OPA1 mitochondrial dynaminMicrotubule associated protein 1 light chain 3Outer mitochondrial membrane 20AMFR/gp78Cellular surveillance systemsMitochondrial membrane proteinInteresting new geneAutocrine motility factor receptorOuter mitochondrial membraneLC3-interacting regionMAP1LC3/LC3Protein 1 light chain 3Blue fluorescent proteinSQSTM1/p62Green fluorescent proteinRed fluorescent proteinReticulophagy regulator 1
2014
Characterization of Unfolding Mechanism of Human Lamin A Ig Fold by Single-Molecule Force SpectroscopyImplications in EDMD
Bera M, Kotamarthi H, Dutta S, Ray A, Ghosh S, Bhattacharyya D, Ainavarapu S, Sengupta K. Characterization of Unfolding Mechanism of Human Lamin A Ig Fold by Single-Molecule Force SpectroscopyImplications in EDMD. Biochemistry 2014, 53: 7247-7258. PMID: 25343322, DOI: 10.1021/bi500726f.Peer-Reviewed Original ResearchConceptsIg domainsBasic nuclear processesB-type laminsC-terminal domainHelical rod domainAutosomal dominant Emery-Dreifuss muscular dystrophySingle-molecule force spectroscopyEmery-Dreifuss muscular dystrophyIntermediate filament proteinsHuman laminLamin proteinsNuclear laminaLamin ALamin A.Nuclear envelopeRod domainNuclear processesUnfolding mechanismFilament proteinsMisshapen nucleiCausative mutationsKey playersR453WLaminsMutations
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