2020
Pulling the springs of a cell by single-molecule force spectroscopy
Mukherjee C, Bera M, Ainavarapu S, Sengupta K. Pulling the springs of a cell by single-molecule force spectroscopy. Emerging Topics In Life Sciences 2020, 5: 77-87. PMID: 33284963, DOI: 10.1042/etls20200254.Peer-Reviewed Original ResearchConceptsSingle-molecule force spectroscopyFilamentous proteinsForce spectroscopyExtracellular matrix proteinsNucleoskeletal proteinsTraction forceMatrix proteinsNecessary anchorageProteinIntermediate filamentsWhole cellsCurrent understandingTissue repairFundamental unitCellsBiochemical changesFibrillar networkMechanotransductionMicrotubulesMicrofilamentsECMFilamentsRegenerationNucleus
2016
Significance of 1B and 2B domains in modulating elastic properties of lamin A
Bera M, Ainavarapu S, Sengupta K. Significance of 1B and 2B domains in modulating elastic properties of lamin A. Scientific Reports 2016, 6: 27879. PMID: 27301336, PMCID: PMC4908593, DOI: 10.1038/srep27879.Peer-Reviewed Original ResearchConceptsLamin ASingle-molecule force spectroscopyRod domainType V intermediate filament proteinsLamin rod domainsSingle molecular levelInner nuclear membraneC-terminal domainIntermediate filament proteinsForce spectroscopyNuclear laminsLaminsNuclear membraneFilament proteinsElastic meshworkNuclear shapeMutationsComparable mechanical propertiesDomainViscoelastic behaviorSpectroscopyLaminopathiesProperties
2014
Characterization of Unfolding Mechanism of Human Lamin A Ig Fold by Single-Molecule Force Spectroscopyî—¸Implications in EDMD
Bera M, Kotamarthi H, Dutta S, Ray A, Ghosh S, Bhattacharyya D, Ainavarapu S, Sengupta K. Characterization of Unfolding Mechanism of Human Lamin A Ig Fold by Single-Molecule Force Spectroscopyî—¸Implications in EDMD. Biochemistry 2014, 53: 7247-7258. PMID: 25343322, DOI: 10.1021/bi500726f.Peer-Reviewed Original ResearchConceptsIg domainsBasic nuclear processesB-type laminsC-terminal domainHelical rod domainAutosomal dominant Emery-Dreifuss muscular dystrophySingle-molecule force spectroscopyEmery-Dreifuss muscular dystrophyIntermediate filament proteinsHuman laminLamin proteinsNuclear laminaLamin ALamin A.Nuclear envelopeRod domainNuclear processesUnfolding mechanismFilament proteinsMisshapen nucleiCausative mutationsKey playersR453WLaminsMutations
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