2021
Calibrating predictive model estimates in a distributed network of patient data
Huang Y, Jiang X, Gabriel R, Ohno-Machado L. Calibrating predictive model estimates in a distributed network of patient data. Journal Of Biomedical Informatics 2021, 117: 103758. PMID: 33811986, DOI: 10.1016/j.jbi.2021.103758.Peer-Reviewed Original ResearchConceptsData privacyRecalibration modelHigh-performance predictive modelsIntegration of dataPatient dataPredictive model estimatesDistributed networkExpected calibration errorMaximum calibration errorPrivacyClinical informaticsCalibration errorsComputational efficiencyPredictive analysisAlgorithmBuilding modelsModel buildingImportant issuePerformance measuresPredictive modelMultiple health systemsLarge numberIsotonic regressionInformaticsSystem
2017
A community effort to protect genomic data sharing, collaboration and outsourcing
Wang S, Jiang X, Tang H, Wang X, Bu D, Carey K, Dyke S, Fox D, Jiang C, Lauter K, Malin B, Sofia H, Telenti A, Wang L, Wang W, Ohno-Machado L. A community effort to protect genomic data sharing, collaboration and outsourcing. Npj Genomic Medicine 2017, 2: 33. PMID: 29263842, PMCID: PMC5677972, DOI: 10.1038/s41525-017-0036-1.Peer-Reviewed Original ResearchGenomic data sharingData sharingSecure computation techniquesPrivacy-preserving techniquesPublic cloud servicesMagnitude performance improvementThird Critical AssessmentData outsourcingCloud servicesPrivacy challengesData privacyHuman genomic dataSecurity researchersPrivacy risksSensitive informationComputer privacyBeacon serviceBiomedical informaticistsSecurity concernsMemory requirementsCollaborative discoveryComputation techniquesComputational runtimePrivacyTrack 2
2016
Protecting genomic data analytics in the cloud: state of the art and opportunities
Tang H, Jiang X, Wang X, Wang S, Sofia H, Fox D, Lauter K, Malin B, Telenti A, Xiong L, Ohno-Machado L. Protecting genomic data analytics in the cloud: state of the art and opportunities. BMC Medical Genomics 2016, 9: 63. PMID: 27733153, PMCID: PMC5062944, DOI: 10.1186/s12920-016-0224-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHuman genomic dataSecure computation techniquesPublic cloud environmentSecure computation methodsGenomic data analyticsReal-world environmentsSecond Critical AssessmentSecure outsourcingCloud environmentCryptographic technologyPublic cloudSecure collaborationUnauthorized usersComputation tasksData privacyData analyticsBiomedical computingData scientistsComputational environmentGenomic dataWorld environmentComputation techniquesMultiple organizationsPractical algorithmPrivacyGenome privacy: challenges, technical approaches to mitigate risk, and ethical considerations in the United States
Wang S, Jiang X, Singh S, Marmor R, Bonomi L, Fox D, Dow M, Ohno‐Machado L. Genome privacy: challenges, technical approaches to mitigate risk, and ethical considerations in the United States. Annals Of The New York Academy Of Sciences 2016, 1387: 73-83. PMID: 27681358, PMCID: PMC5266631, DOI: 10.1111/nyas.13259.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsData privacySensitive individual informationComputer science communityReal-world problemsUnauthorized partiesHuman genomic dataPrivacy breachesData accessData sharingData accessibilityConfidentiality protectionGenomic dataSpectrum of techniquesIndividual informationPrivacyScience communityPhenotype informationTechnical approachPotential solutionsCurrent common practiceBiomedical researchResearch purposesConfidentialityInformationSharing
2014
A community assessment of privacy preserving techniques for human genomes
Jiang X, Zhao Y, Wang X, Malin B, Wang S, Ohno-Machado L, Tang H. A community assessment of privacy preserving techniques for human genomes. BMC Medical Informatics And Decision Making 2014, 14: s1. PMID: 25521230, PMCID: PMC4290799, DOI: 10.1186/1472-6947-14-s1-s1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBiomedical dataPrivacy preserving techniquesPrivacy protection techniquesData privacyBiomedical computingHuman genomic dataData donorsDissemination techniquesPersonal Genome ProjectRaw dataProtection techniquesRigorous protectionPrivacyGenomic dataFinal resultsComputingCommunity effortsAnalysis outcomesChallengesTechniqueDataProject