2024
Anti-inflammatory roles of type I interferon signaling in the lung
Feng J, Liu Y, Kim J, Ahangari F, Kaminski N, Bain W, Jie Z, Dela Cruz C, Sharma L. Anti-inflammatory roles of type I interferon signaling in the lung. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l551-l561. PMID: 38375579, DOI: 10.1152/ajplung.00353.2023.Peer-Reviewed Original ResearchType I interferon signalingIfnar1-/- miceI interferon signalingInflammatory cell responseInflammatory responseIfnar1-/-Bleomycin injuryCell responsesWild-type miceBroncho-alveolar lavageElevated inflammatory responsePersistent inflammatory responseChemotherapeutic agent bleomycinAnti-inflammatory roleClinically relevant stimuliAnti-inflammatory mechanismsMyeloid cellsPersistent inflammationLung injuryFibrotic remodelingBacterial clearanceRIG-I signalingNOD-like receptor signalingLung tissueReceptor signaling
2019
Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii
Marion CR, Lee J, Sharma L, Park KS, Lee C, Liu W, Liu P, Feng J, Gho YS, Dela Cruz CS. Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii. Infection And Immunity 2019, 87: 10.1128/iai.00243-19. PMID: 31262980, PMCID: PMC6704609, DOI: 10.1128/iai.00243-19.Peer-Reviewed Original ResearchConceptsToll-like receptorsPulmonary inflammationOuter membrane vesiclesToll-like receptor 2TLR4-deficient miceVentilator-associated pneumoniaWild-type miceSystemic inflammationNeutrophil recruitmentIntranasal introductionProinflammatory responseReceptor 2Acinetobacter baumanniiInflammationMouse lungHigh mortalityHost factorsWeight lossMicePneumoniaGram-negative bacteriumMembrane vesiclesGram-negative bacteriaTLR2Chemokines
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